Results 21 to 30 of about 25,858 (250)

Importance of Hypervariable Region 2 for Stability and Affinity of a Shark Single-Domain Antibody Specific for Ebola Virus Nucleoprotein. [PDF]

PLoS ONE, 2016
Single-domain antibodies derived from the unique New Antigen Receptor found in sharks have numerous potential applications, ranging from diagnostic reagents to therapeutics.
George P Anderson, Daniel D Teichler, Dan Zabetakis, Lisa C Shriver-Lake, Jinny L Liu, Stephen G Lonsdale, Sarah A Goodchild, Ellen R Goldman   +7 more
doaj   +1 more source

Development of diffuse large B-cell lymphoma in a patient with Waldenström’s macroglobulinemia/ lymphoplasmacytic lymphoma: clonal identity between two B-cell neoplasms

Hematology Reports, 2011
Waldenström’s macroglobulinemia (WM)/ lymphoplasmacytic lymphoma (LPL) is an indolent mature B-cell neoplasm. In rare cases of WM/LPL, diffuse large B-cell lymphoma (DLBCL) develops as a result of histologic transformation.
Masayuki Shiseki, Akihiro Masuda, Norimichi Watanabe, Masami Fujii, Tomofumi Kimura, Kentaro Yoshinaga, Naoki Mori, Masanao Teramura, Toshiko Motoji   +8 more
doaj   +1 more source

Restricted TcR β chain CDR3 clonotype is associated with resolved acute hepatitis B subjects

BMC Infectious Diseases, 2021
Background T cells play an important role in the prognosis of hepatitis B virus (HBV) infection, and are involved in the seroconversion of a patient from HBsAb negative to positive.
Dangsheng Xiao, Ju Wang, Zhitao Chen, Xiuyuan Jin, Yirui Xie, Dong Yan, Jiezuan Yang   +6 more
doaj   +1 more source

Positional Effect of Amino Acid Replacement on Peptide Antigens for the Increased IFN-γ Production from CD4T Cells

Allergology International, 2005
Background: Based on the fact that site-specific amino acid replacement on peptide antigens stimulated T cell clones to produce increased amount of IFN-γ, we investigated this structure-function relationship, using various peptide analogues.
Tianyi Liu, Hitoshi Kohsaka, Motoharu Suzuki, Rie Takagi, Kumiko Hashimoto, Yasushi Uemura, Hideki Ohyama, Sho Matsushita   +7 more
doaj   +1 more source

Composition and Variation Analysis of the T Cell Receptor β‐Chain Complementarity Determining Region 3 Repertoire in Neonatal Sepsis [PDF]

Scandinavian Journal of Immunology, 2017
AbstractT cell receptor (TCR) diversity is clearly related to protection from infection. However, the characteristics of TCR diversity in neonates are not clear. In this study, we investigated the TCR diversity of neonates with sepsis. Twenty neonates with severe sepsis and eight matched neonates without infection were enrolled in the study.
J. Sun, B. Sun, Y. Gao, F. He, L. Yang, M. Wang, W. Zhou   +6 more
openaire   +2 more sources

Structural Diversity of Ultralong CDRH3s in Seven Bovine Antibody Heavy Chains

Frontiers in Immunology, 2019
Antigen recognition by mammalian antibodies represents the most diverse setting for protein-protein interactions, because antibody variable regions contain exceptionally diverse variable gene repertoires of DNA sequences containing combinatorial, non ...
Jinhui Dong, Jessica A. Finn, Peter A. Larsen, Timothy P. L. Smith, James E. Crowe, James E. Crowe, James E. Crowe   +6 more
doaj   +1 more source

Quantitative characterization of the T cell receptor repertoires of human immunized by rabies virus vaccine

Human Vaccines & Immunotherapeutics, 2021
Cellular immunity is crucial for an efficient host immune response against rabies virus (RABV) infection. But the T cell receptor (TCR) repertoire in human after RABV vaccine immunization remained unclear.
Pingsen Zhao, Kaijian Hou, Zhixiong Zhong, Sharula Guo, Songtao Yang, Xianzhu Xia   +5 more
doaj   +1 more source

Analysis of CDR3 Sequences from T-Cell Receptor β in Acute Respiratory Distress Syndrome

Biomolecules, 2023
Acute Respiratory Distress Syndrome (ARDS) is an illness that typically develops in people who are significantly ill or have serious injuries. ARDS is characterized by fluid build-up that occurs in the alveoli. T-cells are implicated as playing a role in
Sara Hey, Dayjah Whyte, Minh-Chau Hoang, Nick Le, Joseph Natvig, Claire Wingfield, Charles Onyeama, Judie Howrylak, Inimary T. Toby   +8 more
doaj   +1 more source

Characteristics of T-cell receptor repertoire of stem cell-like memory CD4+ T cells [PDF]

PeerJ, 2021
Stem cell-like memory T cells (Tscm) combine phenotypes of naïve and memory. However, it remains unclear how T cell receptor (TCR) characteristics contribute to heterogeneity in Tscm and other memory T cells.
Shiyu Wang, Longlong Wang, Yang Liu, Yonggang Zhu, Ya Liu   +4 more
doaj   +2 more sources

High-throughput sequencing of CD4+ T cell repertoire reveals disease-specific signatures in IgG4-related disease

Arthritis Research & Therapy, 2019
Background CD4+ T cells play critical roles in the pathogenesis of IgG4-related disease (IgG4-RD). The aim of this study was to investigate the TCR repertoire of peripheral blood CD4+ T cells in IgG4-RD.
Liwen Wang, Panpan Zhang, Jieqiong Li, Hui Lu, Linyi Peng, Jing Ling, Xuan Zhang, Xiaofeng Zeng, Yan Zhao, Wen Zhang   +9 more
doaj   +1 more source