Results 31 to 40 of about 25,858 (250)

Oligoclonality of TCR^int Cells with a Low Diversity of TCR Complementarity‐Determining Region 3 in Mice with Graft‐ Versus‐Host Disease [PDF]

Scandinavian Journal of Immunology, 1998
Conventional T cells (i.e. TCRhigh) are generated by the main stream of T‐cell differentiation in the thymus. However, primordial T cells (i.e. TCRint) are generated by extrathymic pathways and an alternative intrathymic pathway. Since TCRint cells contain self‐reactive clones, the diversity of the T‐cell antigen receptor (TCR) complementarity ...
S, Sugahara, Y, Kuwano, K, Sato, K, Hasegawa, S, Yamagiwa, T, Kawamura, Y, Yoshida, H, Asakura, T, Abo   +8 more
openaire   +2 more sources

Tracking TCRβ sequence clonotype expansions during antiviral therapy using high-throughput sequencing of the hypervariable region

Frontiers in Immunology, 2016
To maintain a persistent infection viruses such as hepatitis C virus (HCV) employ a range of mechanisms that subvert protective T cell responses. The suppression of antigen-specific T cell responses by HCV hinders efforts to profile T cell responses ...
Mark W Robinson, Mark W Robinson, Joseph eHughes, Gavin S Wilkie, Rachael eSwann, Rachael eSwann, Stephen T Barclay, Peter R Mills, Arvind H Patel, Emma C Thomson, John eMcLauchlan   +10 more
doaj   +1 more source

High-Throughput Sequencing of the Expressed Torafugu (Takifugu rubripes) Antibody Sequences Distinguishes IgM and IgT Repertoires and Reveals Evidence of Convergent Evolution

Frontiers in Immunology, 2018
B-cell antigen receptor (BCR) or antibody diversity arises from somatic recombination of immunoglobulin (Ig) gene segments and is concentrated within the Ig heavy (H) chain complementarity-determining region 3 (CDR-H3).
Xi Fu, Xi Fu, Jianqiang Sun, Engkong Tan, Kentaro Shimizu, Md Shaheed Reza, Md Shaheed Reza, Shugo Watabe, Shuichi Asakawa   +8 more
doaj   +1 more source

Vγ9Vδ2 T-Cell Anergy and Complementarity-Determining Region 3-Specific Depletion during Paroxysm of Nonendemic Malaria Infection [PDF]

Infection and Immunity, 2003
ABSTRACTVγ9Vδ2 T lymphocytes strongly respond to phosphoantigens fromPlasmodiumparasites. Thus, we analyzed the changes in Vγ9Vδ2 T-cell function and repertoire during the paroxysm phase of nonendemic malaria infection. During malaria paroxysm, Vγ9Vδ2 T cells were early activated but rapidly became anergic and finally loose Jγ1.2 Vγ9 complementarity ...
Martini, F, Paglia, MG, MONTESANO, CARLA, Enders, PJ, Gentile, M, Pauza, CD, Gioia, C, COLIZZI, VITTORIO, Narciso, P, Pucillo, LP, Poccia, F.   +10 more
openaire   +4 more sources

Many Routes to an Antibody Heavy-Chain CDR3: Necessary, Yet Insufficient, for Specific Binding

Frontiers in Immunology, 2018
Because of its great potential for diversity, the immunoglobulin heavy-chain complementarity-determining region 3 (HCDR3) is taken as an antibody molecule’s most important component in conferring binding activity and specificity.
Sara D’Angelo, Fortunato Ferrara, Leslie Naranjo, M. Frank Erasmus, Peter Hraber, Andrew R. M. Bradbury   +5 more
doaj   +1 more source

Characterization of the Human Ig Heavy Chain Antigen Binding Complementarity Determining Region 3 Using a Newly Developed Software Algorithm, JOINSOLVER [PDF]

The Journal of Immunology, 2004
Abstract We analyzed 77 nonproductive and 574 productive human VHDJH rearrangements with a newly developed program, JOINSOLVER. In the productive repertoire, the H chain complementarity determining region 3 (CDR3H) was significantly shorter (46.7 ± 0.5 nucleotides) than in the nonproductive repertoire (53.8 ± 1.9 nucleotides) because ...
M Margarida, Souto-Carneiro, Nancy S, Longo, Daniel E, Russ, Hong-wei, Sun, Peter E, Lipsky   +4 more
openaire   +2 more sources

Immune receptor repertoires in pediatric and adult acute myeloid leukemia

Genome Medicine, 2019
Background Acute myeloid leukemia (AML), caused by the abnormal proliferation of immature myeloid cells in the blood or bone marrow, is one of the most common hematologic malignancies.
Jian Zhang, Xihao Hu, Jin Wang, Avinash Das Sahu, David Cohen, Li Song, Zhangyi Ouyang, Jingyu Fan, Binbin Wang, Jingxin Fu, Shengqing Gu, Moshe Sade-Feldman, Nir Hacohen, Wuju Li, Xiaomin Ying, Bo Li, X. Shirley Liu   +16 more
doaj   +1 more source

Diversity in the Complementarity-Determining Region 3 (CDR3) of Antibodies from Mice with Evolving Anti-Thyroid-Stimulating Hormone Receptor Antibody Responses [PDF]

Endocrinology, 2007
In a mouse model of autoimmune Graves' disease, stimulatory anti-TSH receptor (TSHR) antibodies (TSAbs) slowly evolve upon repeated immunization with TSHR and lead to hyperthyroidism. Although all immunized mice developed high levels of TSH-binding inhibitory Ig (TBII), only a subset of these mice become hyperthyroid, suggesting that the generation of ...
Osvaldo, Martinez, Eryn, Gangi, David, Mordi, Sonal, Gupta, Samuel, Dorevitch, Marie-Paule, Lefranc, Bellur S, Prabhakar   +6 more
openaire   +2 more sources

Analysis of CDR3 region diversity with different lengths in bovine immunoglobulin heavy chain genes

Frontiers in Immunology
IntroductionCattle produce a unique antibody repertoire characterized by an exceptionally wide range of complementarity determining region 3 heavy chain (CDR3H) lengths, spanning from 1 bp to 204 bp—a feature that is extremely rare among mammals.
Haidong Zhao, Haidong Zhao, Haidong Zhao, Xiaoqin Tang, Yuelang Zhang, Mingli Wu   +5 more
doaj   +1 more source

Chemical Complementarity of Breast Cancer Resident, T-Cell Receptor CDR3 Domains and the Cancer Antigen, ARMC3, is Associated With Higher Levels of Survival and Granzyme Expression

Cancer Informatics, 2023
Introduction: One of the most pressing goals for cancer immunotherapy at this time is the identification of actionable antigens. Methods: This study relies on the following considerations and approaches to identify potential breast cancer antigens: (i ...
Nagehan Pakasticali, Andrea Chobrutskiy, Dhruv N. Patel, Monica Hsiang, Saif Zaman, Konrad J. Cios, George Blanck, Boris I. Chobrutskiy   +7 more
doaj   +1 more source