Results 71 to 80 of about 1,001,403 (229)

The complete chloroplast genome sequence of Zanthoxylum armatum

Mitochondrial DNA. Part B. Resources, 2019
The first complete chloroplast genome sequences of Zanthoxylum armatum were reported in this study. The cpDNA of Z. armatum is 158,579 bp in length, contains a large single copy region (LSC) of 85,780 bp and a small single copy region (SSC) of 17,598 bp,
Yi Wang, Jiabo Hao, Xiaolong Yuan, Yongkang Sima, Bin Lu   +4 more
doaj   +1 more source

The complete chloroplast genome sequence of Kadsura heteroclita

Mitochondrial DNA. Part B. Resources, 2020
The first complete chloroplast genome (cpDNA) sequence of Kadsura heteroclita was determined from Illumina HiSeq pair-end sequencing data in this study. The cpDNA is 153,289 bp in length, contains a large single copy region (LSC) of 85,774 bp and a small
Qinghua Wang, Huangyijun Wang, Yupin Fu, Yunqin Li, Xiaolong Yuan, Yi Wang   +5 more
doaj   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

The complete chloroplast genome sequence of Rubus cochinchinensis

Mitochondrial DNA. Part B. Resources, 2020
Rubus Linnaeus has long been deemed as one of the most diverse genera in family Rosaceae as well as an extremely challenging group with complicated intra-and-inter relationships at species level.
Yan Zhao Chen, Wei Guo, Longyuan Wang, Wei Wu, Yongquan Li   +4 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

The complete chloroplast genome sequence of Heracleum yungningense

Mitochondrial DNA. Part B. Resources, 2020
Heracleum yungningense is a traditional medicinal plant widely used in China. Here, we reported the complete chloroplast genome of H. yungningense using Illumina paired-end sequencing. The whole genome is 149,223 bp in length, which contains a pair of 18,
Zhen-Ying Zheng, Jun Li, Deng-Feng Xie, Song-Dong Zhou, Xing-Jin He   +4 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The complete chloroplast genome sequence of Qercus pannosa

Mitochondrial DNA. Part B. Resources, 2020
The first complete chloroplast genome (cpDNA) sequence of Quercus pannosa was determined from Illumina HiSeq pair-end sequencing data in this study. The cpDNA is 161,222 bp in length, contains a large single-copy region (LSC) of 90,522 bp and a small ...
Jianzhong Ma, Yunqin Li, Xiaolong Yuan, Ting Luo, Yi Wang   +4 more
doaj   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source