Correction for Bera et al., Synaptophysin chaperones the assembly of 12 SNAREpins under each ready-release vesicle. [PDF]
europepmc +1 more source
Human pegivirus alters brain and blood immune and transcriptomic profiles of patients with Parkinson's disease. [PDF]
Hanson BA +9 more
europepmc +1 more source
Regulation of NTRK2 alternative splicing by PRPF40B controls neural differentiation and synaptic plasticity. [PDF]
Duarte-Ruiz M +12 more
europepmc +1 more source
Neuroserpin normalization by mesenchymal stem cell therapy after encephalopathy of prematurity in neonatal rats. [PDF]
Wang LW +4 more
europepmc +1 more source
Dynamic nanoscale architecture of synaptic vesicle fusion in mouse hippocampal neurons. [PDF]
Kroll J +9 more
europepmc +1 more source
Eight decades of follow-up link life course exposures to proteomic organ ageing and longevity
Groves JW +13 more
europepmc +1 more source
Three-Dimensional Structure of the Complexin/SNARE Complex [PDF]
During neurotransmitter release, the neuronal SNARE proteins synaptobrevin/VAMP, syntaxin, and SNAP-25 form a four-helix bundle, the SNARE complex, that pulls the synaptic vesicle and plasma membranes together possibly causing membrane fusion. Complexin binds tightly to the SNARE complex and is essential for efficient Ca(2+)-evoked neurotransmitter ...
Diana R Tomchick +2 more
exaly +4 more sources
Synaptic Vesicles Position Complexin to Block Spontaneous Fusion [PDF]
Synapses continually replenish their synaptic vesicle (SV) pools while suppressing spontaneous fusion events, thus maintaining a high dynamic range in response to physiological stimuli. The presynaptic protein complexin can both promote and inhibit fusion through interactions between its α-helical domain and the SNARE complex.
David Snead, Yongming Dong, Jihong Bai
exaly +3 more sources

