Results 181 to 190 of about 11,278 (212)
The primed SNARE–complexin–synaptotagmin complex for neuronal exocytosis [PDF]
Nature, 2017 Synaptotagmin, complexin, and neuronal SNARE (soluble N-ethylmaleimide sensitive factor attachment protein receptor) proteins mediate evoked synchronous neurotransmitter release, but the molecular mechanisms mediating the cooperation between these molecules remain unclear.
Qiangjun Zhou, Peng Zhou, Minglei Zhao
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Regulation of complexin 1 and complexin 2 in the developing human prefrontal cortex
Synapse, 2008AbstractComplexin 1 (CX1) and complexin 2 (CX2) are presynaptic proteins that modulate neurotransmitter release and are used as markers of inhibitory and excitatory synapses, respectively. The aim of this study was to gain insight into the development of inhibitory and excitatory synapses in human prefrontal cortex (PFC) by examining the expression of ...
Kayvon, Salimi +5 more
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CLINICAL SYMPTOM COMPLEXIN VERTEBROGENIC LUMBOSACRAL RADICULOPATHY
Oriental Journal of Medicine and Pharmacology, 2022Vertebrogenic lumbosacral radiculopathy, being a global problem of modern healthcare, occupies one of the leading places among the reasons for visiting doctors of various specialties and disability of people of different age categories. According to modern scientific medical research by a number of authors, an episode of back pain, at least once in a ...
M.B. Urinov, M.M. Usmonov
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Cloning and expression of a leech complexin
Gene Expression Patterns, 2004Release of neurotransmitter from presynaptic nerve terminals is mediated by SNARE proteins, which are located on the vesicle and plasma membranes. These proteins form a SNARE complex thought to mediate membrane fusion. Complexin is a soluble protein essential for transmitter release, which has been postulated to bind to and stabilise the SNARE complex.
Dykes, Iain M, Davies, Jane A
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Hippocampal Complexin Proteins and Cognitive Dysfunction in Schizophrenia [PDF]
Archives of General Psychiatry, 2005 Converging neuroimaging and postmortem evidence indicates synaptic terminals are abnormal in schizophrenia. A putative molecular mechanism implicates abnormalities of proteins involved in the presynaptic secretory machinery, including the modulator proteins complexin I and complexin II.To determine the amount and distribution of complexin proteins in ...
Ken Sawada +2 more
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European Journal of Neuroscience, 2012
AbstractComplexins (Cplxs) regulate the speed and Ca2+‐sensitivity of synaptic vesicle fusion. It has been shown that all four known Cplxs are present at mouse retinal synapses – at conventional amacrine cell synapses (Cplx 1 to Cplx 3) and at photoreceptor and bipolar cell ribbon synapses (Cplx 3 and Cplx 4) [K. Reim et al. (2005)J.
Landgraf, I. +5 more
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AbstractComplexins (Cplxs) regulate the speed and Ca2+‐sensitivity of synaptic vesicle fusion. It has been shown that all four known Cplxs are present at mouse retinal synapses – at conventional amacrine cell synapses (Cplx 1 to Cplx 3) and at photoreceptor and bipolar cell ribbon synapses (Cplx 3 and Cplx 4) [K. Reim et al. (2005)J.
Landgraf, I. +5 more
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Nature Structural & Molecular Biology, 2011
Mechanistic details about complexin's contradictory double life as both a facilitator and an inhibitor of SNARE-mediated synaptic vesicle fusion have been challenging to uncover. A series of studies in this issue addresses the problem by revealing a switchable complexin conformation in which fusion arrest occurs when complexin clamps neighboring SNAREs.
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Mechanistic details about complexin's contradictory double life as both a facilitator and an inhibitor of SNARE-mediated synaptic vesicle fusion have been challenging to uncover. A series of studies in this issue addresses the problem by revealing a switchable complexin conformation in which fusion arrest occurs when complexin clamps neighboring SNAREs.
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Complexin Membrane Interactions: Implications for Synapse Evolution and Function
Journal of Molecular Biology, 2023The molecules and mechanisms behind chemical synaptic transmission have been explored for decades. For several of the core proteins involved in synaptic vesicle fusion, we now have a reasonably detailed grasp of their biochemical, structural, and functional properties.
Justine A, Lottermoser +1 more
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Characterization of the Complexin Membrane Interaction
2021In neuronal exocytosis, neurotransmitters are released via membrane fusion between synaptic vesicle and presynaptic plasma membrane. Assembly of the soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) drive this membrane fusion in a millisecond within the Ca2+ trigger.
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ComPLEXIN new targets for CIITA
Nature Immunology, 2003Growing evidence indicates immune and nervous systems use common mechanisms to mediate intercellular communication. Adding to this list is the discovery that dendritic cells modulate T cell interactions through expression of the neuronal receptor plexin-A1, which is regulated by the transcriptional activator CIITA.
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