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Regulation of SNAREs: Complexin
2014Complexin (also called as synaphin), a small cytoplasmic protein, binds to SNAP receptor (SNARE) complex (membrane fusion machinery) and regulates neurotransmitter release at the post-priming stage. Several lines of evidence have demonstrated that complexin has at least two independent roles: clamping of the trans-SNARE complex and activation of Ca2 ...
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Role of complexin in regulated exocytosis
2015Properly regulated exocytosis of neurotransmitters and hormones from membrane-delimited vesicles is essential for normal cellular function. At least 3 distinct steps are involved in regulated exocytosis: (1) the docking of vesicles at the appropriate plasma membrane, (2) priming of a subset of docked vesicles to become release-competent, i.e.
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Investigating Complexin-Membrane Interactions Using NMR and Optical Methods
Complexins are a family of small presynaptic proteins that regulate neurotransmitter release at nerve terminals and are highly conserved in evolution. While direct interactions with SNARE proteins are critical for all complexin functions, binding of their disordered C-terminal domains (CTD) to membranes, especially to synaptic vesicle membranes, is ...Emily M, Grasso, David, Eliezer
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A Complexin/Synaptotagmin 1 Switch Controls Fast Synaptic Vesicle Exocytosis
Cell, 2006Anton Maximov, Ok-Ho Shin, Josep Rizo
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Should I stop or should I go? The role of complexin in neurotransmitter release
Nature Reviews Neuroscience, 2016Thorsten Trimbuch, Christian Rosenmund
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[Research progress in complexin].
Sheng li ke xue jin zhan [Progress in physiology], 2005Chen-Xi, Liu +3 more
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