Results 111 to 120 of about 2,943 (163)

Structural similarities reveal an expansive conotoxin family with a two-finger toxin fold. [PDF]

Protein Sci
Khilji MS, Hackney CM, Koch TL, Hone AJ, Rogalski A, Watkins M, Tun J, McIntosh JM, Olivera B, Safavi-Hemami H, Teilum K, Ellgaard L.   +11 more
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Novel Pharmacological Targets From Indian Cone Snails

Mini-Reviews in Medicinal Chemistry, 2011
The oceans are a source of combinatorial library of unique natural products, 'not found in the terrestrial environment'. Marine invertebrates such as sponges, molluscs, bryozoans, tunicates (Urochordata) and their associated microorganisms are the major representatives of promising bioactive compounds.
M Santhana, Ramasamy, S, Manikandan
openaire   +2 more sources

Peptide Neurotoxins from Fish-Hunting Cone Snails

Science, 1985
To paralyze their more agile prey, the venomous fish-hunting cone snails ( Conus ) have developed a potent biochemical strategy. They produce several classes of toxic peptides (conotoxins) that attack a series of successive physiological targets in the neuromuscular system of the fish.
B M, Olivera, W R, Gray, R, Zeikus, J M, McIntosh, J, Varga, J, Rivier, V, de Santos, L J, Cruz   +7 more
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Therapeutic Potential of Cone Snail Venom Peptides (Conopeptides)

Current Topics in Medicinal Chemistry, 2012
Cone snails have evolved many 1000s of small, structurally stable venom peptides (conopeptides) for prey capture and defense. Whilst < 0.1% have been pharmacologically characterised, those with known function typically target membrane proteins of therapeutic importance, including ion channels, transporters and GPCRs. Several conopeptides reduce pain in
Vetter, Irina, Lewis, Richard J.
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Cone snails lure prey with faux pheromones

C&EN Global Enterprise, 2021
Cone snails use venom when hunting their prey. While much is known about the peptides in cone snail venom , the small molecules it contains have until now not been well characterized—especially in ...
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Neurotoxins of Cone Snail Venoms

2002
Cone snails are predatory marine mollusks that rely on their venom components to immobilize and capture fish, worms, or other mollusks. Cones employ a number of prey-hunting strategies, ultimately involving the injection of venom through a hollow, harpoon-like, modified-tooth structure (1).
Robert Newcomb, George Miljanich
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Ichthyotoxicity caused by marine cone snail venoms?

Toxicon, 2005
Ten venoms from marine cone snails were tested for ichthyotoxic effects on zebra fish (Brachydanio rerio) when added to the water. Only two venoms, from Conus capitaneus and Conus episcopatus, produced lethal effects at high concentrations (50-300 microg/ml) within 20-90 min. No sedative or hypnotic symptoms were observed.
Dietrich, Mebs, Silke, Kauferstein
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From a Cone Snail Toxin to a Competitive MC4R Antagonist

Journal of Medicinal Chemistry, 2022
The melanocortin 4 receptor (MC4R) plays a role in energy homeostasis and represents a target for treating energy balance disorders. For decades, synthetic ligands have been derived from MC4R endogenous agonists and antagonists, such as setmelanotide used to treat rare forms of genetic obesity.
Reynaud, Steve, Laurin, Suli-Anne, Ciolek, Justyna, Barbe, Peggy, van Baelen, Anne-Cécile, Susset, Michaël, Blondel, Florian, Ghazarian, Marine, Boeri, Julia, Vanden Driessche, Margot, Upert, Grégory, Mourier, Gilles, Kessler, Pascal, Konnert, Laure, Beroud, Rémy, Keck, Mathilde, Servent, Denis, Bouvier, Michel, Gilles, Nicolas   +18 more
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