Results 71 to 80 of about 267,969 (148)

Diversity of conotoxin gene superfamilies in the venomous snail, Conus victoriae. [PDF]

PLoS ONE, 2014
Animal venoms represent a vast library of bioactive peptides and proteins with proven potential, not only as research tools but also as drug leads and therapeutics.
Samuel D Robinson, Helena Safavi-Hemami, Lachlan D McIntosh, Anthony W Purcell, Raymond S Norton, Anthony T Papenfuss   +5 more
doaj   +1 more source

Animal Venoms as Peptide Libraries for the Discovery of Antiglioblastoma Agents

Biochemistry Research International, Volume 2026, Issue 1, 2026.
Glioblastoma is one of the most aggressive and widely recognized types of brain tumors, characterized by significant cellular and molecular diversity and an inherently aggressive nature. The treatment remains highly challenging, with limited effectiveness and persistently low survival rates.
Livia Ramos Santiago, Edgar Alejandro Pinos Tamayo, Daniel Moreira dos Santos, Bonglee Kim, José R. Almeida, Rosy Iara Maciel de Azambuja Ribeiro, Marco Eigenfeld   +6 more
wiley   +1 more source

Conotoxins Targeting Nicotinic Acetylcholine Receptors: An Overview

Marine Drugs, 2014
Marine snails of the genus Conus are a large family of predatory gastropods with an unparalleled molecular diversity of pharmacologically active compounds in their venom.
Eline K. M. Lebbe, Steve Peigneur, Isuru Wijesekara, Jan Tytgat   +3 more
doaj   +1 more source

Curses or Cures: A Review of the Numerous Benefits Versus the Biosecurity Concerns of Conotoxin Research

Biomedicines, 2020
Conotoxins form a diverse group of peptide toxins found in the venom of predatory marine cone snails. Decades of conotoxin research have provided numerous measurable scientific and societal benefits.
Walden E. Bjørn-Yoshimoto, Iris Bea L. Ramiro, Mark Yandell, J. Michael McIntosh, Baldomero M. Olivera, Lars Ellgaard, Helena Safavi-Hemami   +6 more
doaj   +1 more source

Genetic Structure in a Trans‐Oceanic Hot Vent Mussel Reveals Four Metapopulations With Implications for Conservation

Journal of Biogeography, Volume 52, Issue 10, October 2025.
ABSTRACT Aim Genetic diversity and connectivity are crucial to informing the conservation strategy for deep‐sea organisms, especially those threatened by deep‐sea mining. The vent mussel Bathymodiolus septemdierum has an extraordinary trans‐oceanic distribution range across the Indo‐West Pacific including numerous sites eyed for exploitation.
Qin Mao, Chong Chen, Jin Sun, Jin Liang, Yanan Sun, Yejian Wang, Cong Zeng, Mingting Li, Shuaicheng Xin, Dongsheng Zhang, Yadong Zhou   +10 more
wiley   +1 more source

The Untapped Potential of Cone Snail Venom Peptides: Conopressin’s Modulation of Oxytocin and Vasopressin Hormone Receptors [PDF]

25 pagesThis paper provides a review of the medical and research applications of cone snail venom components. Cone snail venom contains specialized peptides called conopeptides which are estimated to number more than 800,000 in total from across all cone
Ford, Jackson
core   +1 more source

Characterization of the First Conotoxin from Conus ateralbus, a Vermivorous Cone Snail from the Cabo Verde Archipelago

Marine Drugs, 2019
Conus ateralbus is a cone snail endemic to the west side of the island of Sal, in the Cabo Verde Archipelago off West Africa. We describe the isolation and characterization of the first bioactive peptide from the venom of this species.
Jorge L. B. Neves, Julita S. Imperial, David Morgenstern, Beatrix Ueberheide, Joanna Gajewiak, Agostinho Antunes, Samuel D. Robinson, Samuel Espino, Maren Watkins, Vitor Vasconcelos, Baldomero M. Olivera   +10 more
doaj   +1 more source

Proteomic analysis of the venom of Conus flavidus from Red Sea reveals potential pharmacological applications

Journal of Genetic Engineering and Biotechnology
Background: Venomous marine cone snails produce unique neurotoxins called conopeptides or conotoxins, which are valuable for research and drug discovery.
Mousa O. Germoush, Maged Fouda, Hamdy Aly, Islam Saber, Barakat M. Alrashdi, Diaa Massoud, Sarah Alzwain, Ahmed E. Altyar, Mohamed M. Abdel-Daim, Moustafa Sarhan   +9 more
doaj   +1 more source

Screening and Validation of Highly-Efficient Insecticidal Conotoxins from a Transcriptome-Based Dataset of Chinese Tubular Cone Snail

Toxins, 2017
Most previous studies have focused on analgesic and anti-cancer activities for the conotoxins identified from piscivorous and molluscivorous cone snails, but little attention has been devoted to insecticidal activity of conotoxins from the dominant ...
Bingmiao Gao, Chao Peng, Bo Lin, Qin Chen, Junqing Zhang, Qiong Shi   +5 more
doaj   +1 more source

Glycosylation of Conotoxins

Marine Drugs, 2013
Conotoxins are small peptides present in the venom of cone snails. The snail uses this venom to paralyze and capture prey. The constituent conopeptides display a high level of chemical diversity and are of particular interest for scientists as tools ...
Rolf Boelens, Johannis P. Kamerling, Reto Stöcklin, Henry G. Hocking, Gerrit J. Gerwig   +4 more
doaj   +1 more source