Results 71 to 80 of about 1,336 (154)

Characterization of the First Conotoxin from Conus ateralbus, a Vermivorous Cone Snail from the Cabo Verde Archipelago

Marine Drugs, 2019
Conus ateralbus is a cone snail endemic to the west side of the island of Sal, in the Cabo Verde Archipelago off West Africa. We describe the isolation and characterization of the first bioactive peptide from the venom of this species.
Jorge L. B. Neves, Julita S. Imperial, David Morgenstern, Beatrix Ueberheide, Joanna Gajewiak, Agostinho Antunes, Samuel D. Robinson, Samuel Espino, Maren Watkins, Vitor Vasconcelos, Baldomero M. Olivera   +10 more
doaj   +1 more source

Proteomic analysis of the venom of Conus flavidus from Red Sea reveals potential pharmacological applications

Journal of Genetic Engineering and Biotechnology
Background: Venomous marine cone snails produce unique neurotoxins called conopeptides or conotoxins, which are valuable for research and drug discovery.
Mousa O. Germoush, Maged Fouda, Hamdy Aly, Islam Saber, Barakat M. Alrashdi, Diaa Massoud, Sarah Alzwain, Ahmed E. Altyar, Mohamed M. Abdel-Daim, Moustafa Sarhan   +9 more
doaj   +1 more source

An N‐Terminally Elongated Peptide From Conus rolani Defines a New Class of Ribbon α‐Conotoxins Targeting Muscle nAChRs

The FASEB Journal, Volume 39, Issue 12, 30 June 2025.
α‐RoIA is an atypical N‐terminally elongated conotoxin discovered in Conus rolani. N‐terminal elongation delays activity in vivo; however, this elongation must be removed to block muscle nicotinic acetylcholine receptors (nAChRs). Only the truncated ribbon isoform of RoIA blocks muscle nAChRs.
Matías L. Giglio, Paula Flórez‐Salcedo, Layla Azam, Maren Watkins, Thomas Lund Koch, Erianna Basgall‐De la Rosa, Adam D. Douglass, J. Michael McIntosh, Baldomero M. Olivera, Joanna Gajewiak   +9 more
wiley   +1 more source

Screening and Validation of Highly-Efficient Insecticidal Conotoxins from a Transcriptome-Based Dataset of Chinese Tubular Cone Snail

Toxins, 2017
Most previous studies have focused on analgesic and anti-cancer activities for the conotoxins identified from piscivorous and molluscivorous cone snails, but little attention has been devoted to insecticidal activity of conotoxins from the dominant ...
Bingmiao Gao, Chao Peng, Bo Lin, Qin Chen, Junqing Zhang, Qiong Shi   +5 more
doaj   +1 more source

Cone snail genome sheds light on venom evolution

, 2021
<strong> This week in <em> GigaScience </em> we published the genome of the mediterranean cone snail, <em> Lautoconus ventricosus </em> . Cone snails produce a wide variety of powerful toxins and the new chromosome-scale genome assembly opens the door for detailed investigations of their diversity and evolution.
openaire   +1 more source

Novel Conopeptides of Largely Unexplored Indo Pacific Conus sp.

Marine Drugs, 2016
Cone snails are predatory creatures using venom as a weapon for prey capture and defense. Since this venom is neurotoxic, the venom gland is considered as an enormous collection of pharmacologically interesting compounds having a broad spectrum of ...
Eline K. M. Lebbe, Maarten G. K. Ghequire, Steve Peigneur, Bea G. Mille, Prabha Devi, Samuthirapandian Ravichandran, Etienne Waelkens, Lisette D’Souza, René De Mot, Jan Tytgat   +9 more
doaj   +1 more source

Potential Ancestral Conoidean Toxins in the Venom Cocktail of the Carnivorous Snail Raphitoma purpurea (Montagu, 1803) (Neogastropoda: Raphitomidae)

Toxins
Venomous marine gastropods of the superfamily Conoidea possess a rich arsenal of toxins, including neuroactive toxins. Venom adaptations might have played a fundamental role in the radiation of conoideans; nevertheless, there is still no knowledge about ...
Giacomo Chiappa, Giulia Fassio, Maria Vittoria Modica, Marco Oliverio   +3 more
doaj   +1 more source

Glycosylation of Conotoxins

Marine Drugs, 2013
Conotoxins are small peptides present in the venom of cone snails. The snail uses this venom to paralyze and capture prey. The constituent conopeptides display a high level of chemical diversity and are of particular interest for scientists as tools ...
Rolf Boelens, Johannis P. Kamerling, Reto Stöcklin, Henry G. Hocking, Gerrit J. Gerwig   +4 more
doaj   +1 more source

Biodiversity2Drugs—Renaissance of exploring nature‐derived peptides for GPCR ligand discovery

British Journal of Pharmacology, Volume 182, Issue 16, Page 3691-3694, August 2025.
Christian W. Gruber, Isabel Beets, Pierre‐Luc Boudreault, Vanderlan da S. Bolzani, Jens Carlsson, Pedro A. Fernandes, Michael Freissmuth, Nicolas Gilles, Ulf Göransson, Alexander S. Hauser, Christian Heinis, Jeroen Kool, William D. Lubell, Maria Vittoria Modica, Jana Selent, Jan Tytgat, Eivind A. B. Undheim, The Biodiversity2Drugs Consortium, Christian W. Gruber, Michael Freissmuth, Nicolas Gilles, Marion Chaigneau, Xavier Iturrioz, Pascal Kessler, Philippe Robin, Isabel Beets, Eivind A. B. Undheim, Jeroen Kool, Rob Leurs, Henry Vischer, Jan Tytgat, Steve Peigneur, Kathleen Carleer, Vanderlan da S. Bolzani, Ana Leticia Piros, William Lubell, Pierre‐Luc Boudreault, Alexander S. Hauser, Luuk R. Hoegen Dijkhof, Teemu K. E. Rönkkö, Maria Vittoria Modica, Serena Leone, Giovanna Ponte, Pedro Fernandes, Maria Joao Ramos, Jana Selent, Elizaveta Korchevaya, Tomasz Stepniewski, Jens Carlsson, Israel Cabeza de Vaca, Ulf Göransson, Sunithi Gunasekera, Erik Jacobsson, Christian Heinis, Tao Che, Maurice R. Elphick, Peter J. McCormick, Samuel Robinson, Helena Safavi‐Hemami, Roderich D. Süssmuth, Axel Touchard, Wilfred A. van der Donk, Denise Wootten, Julius Hermes, Johannes Schneider, Ana Leticia Pires, Marin Matic, António J. M. Ribeiro, João Sousa, Joana Ribeiro da Silva, Lauri Urvas, Arun Shukla   +71 more
wiley   +1 more source

Characterization of the Conus bullatus genome and its venom-duct transcriptome

BMC Genomics, 2011
Background The venomous marine gastropods, cone snails (genus Conus), inject prey with a lethal cocktail of conopeptides, small cysteine-rich peptides, each with a high affinity for its molecular target, generally an ion channel, receptor or transporter.
Olivera Baldomero M, Bandyopadhyay Pradip K, Hu Hao, Yandell Mark   +3 more
doaj   +1 more source