Results 81 to 90 of about 1,336 (154)

ω-Conotoxins GVIA, MVIIA and CVID: SAR and Clinical Potential

Marine Drugs, 2006
: Highly selective N-type voltage-gated calcium (CaV) channel inhibitors from cone snail venom (the ω-conotoxins) have emerged as a new class of therapeutics for the treatment of chronic and neuropathic pain.
Richard J. Lewis, Christina I. Schroeder
doaj   +1 more source

A structurally minimized yet fully active insulin based on cone-snail venom insulin principles. [PDF]

Nat Struct Mol Biol, 2020
Xiong X, Menting JG, Disotuar MM, Smith NA, Delaine CA, Ghabash G, Agrawal R, Wang X, He X, Fisher SJ, MacRaild CA, Norton RS, Gajewiak J, Forbes BE, Smith BJ, Safavi-Hemami H, Olivera B, Lawrence MC, Chou DH.   +18 more
europepmc   +1 more source

From Neuropeptides to Toxins: Illuminating the Origins of Venom Complexity in Cone Snails

New genes and gene functions are key drivers of evolutionary innovation. Venomous animals, such as cone snails, provide striking examples of gene innovation, yet the mechanisms by which toxins arise remain poorly understood. Using the Conus textile genome, we uncover how neuropeptide genes were recruited into the venom and neofunctionalized as ...
Koch, Thomas Lund, Ferrari, Giada, Sumanam, Sunita B, Salcedo, Paula Flórez, Watkins, Maren, Chase, Kevin, Tooming-Klunderud, Ave, Lluisma, Arturo O, Yanagihara, Angel, Young, Neil D, Olivera, Baldomero M, Undheim, Eivind A.B., Safavi-Hemami, Helena   +12 more
openaire   +3 more sources

Conodipine-P1-3, the First Phospholipases A₂ Characterized from Injected Cone Snail Venom. [PDF]

Mol Cell Proteomics, 2019
Möller C, Davis WC, Clark E, DeCaprio A, Marí F.   +4 more
europepmc   +1 more source

Venom Apparatus Structure and Conutoxins Granules formation in Cone Snail (Conus coronatus) of Persian Gulf

Iranian South Medical Journal, 2014
Background: Today use conotoxin as a neurotoxin and cytotoxin in medical science is obvious. These compounds are produced by venomous cone snails. Toxins produced by the venom apparatus of this snail and injected into the prey.
Ferial Monsef, Saber Khodabandeh, Iraj Nabipour   +2 more
doaj  

Discovery by proteogenomics and characterization of an RF-amide neuropeptide from cone snail venom. [PDF]

J Proteomics, 2015
Robinson SD, Safavi-Hemami H, Raghuraman S, Imperial JS, Papenfuss AT, Teichert RW, Purcell AW, Olivera BM, Norton RS.   +8 more
europepmc   +1 more source

Cone snail venom-inspired somatostatin receptor 4 (SSTR₄) agonists as new drug leads for peripheral pain. [PDF]

Sci Rep
Bjørn-Yoshimoto WE, Ramiro IBL, Koch TL, Engholm E, Yeung HY, Sørensen KK, Goddard CM, Jensen KL, Smith NA, Martin LF, Smith BJ, Madsen KL, Jensen KJ, Patwardhan A, Safavi-Hemami H.   +14 more
europepmc   +1 more source

From DNA enzymes to cone snail venom: the work of Baldomero M. Olivera. [PDF]

J Biol Chem, 2012
Mukhopadhya R.
europepmc   +1 more source

The Venom Revolution in Biomedicine: Unlocking Nature's Toxin Toolkit for Therapeutic Innovation. [PDF]

Toxicol Rep
Bose D, Srinivasan K, Patil SS, Nayak AG, Hariharapura RC.   +4 more
europepmc   +1 more source

Venom Proteins of the Firefly <i>Pyrocoelia analis</i> Revealed by Transcriptome Analysis. [PDF]

Toxins (Basel)
Liu G, Cao C, Chen L, Huang R, Li L, Meng E, Liu C, Du C.   +7 more
europepmc   +1 more source