Results 81 to 90 of about 5,046 (227)

Discovery Methodology of Novel Conotoxins from Conus Species

Marine Drugs, 2018
Cone snail venoms provide an ideal resource for neuropharmacological tools and drug candidates discovery, which have become a research hotspot in neuroscience and new drug development. More than 1,000,000 natural peptides are produced by cone snails, but
Ying Fu, Cheng Li, Shuai Dong, Yong Wu, Dongting Zhangsun, Sulan Luo   +5 more
doaj   +1 more source

Synthesis, Pharmacological and Structural Characterization of Novel Conopressins from Conus miliaris

Marine Drugs, 2020
Cone snails produce a fast-acting and often paralyzing venom, largely dominated by disulfide-rich conotoxins targeting ion channels. Although disulfide-poor conopeptides are usually minor components of cone snail venoms, their ability to target key ...
Julien Giribaldi, Lotten Ragnarsson, Tom Pujante, Christine Enjalbal, David Wilson, Norelle L. Daly, Richard J. Lewis, Sebastien Dutertre   +7 more
doaj   +1 more source

A novel α-conotoxin, PeIA, cloned from Conus pergrandis, discriminates between Rat α9α10 and α7 nicotinic cholinergic receptors [PDF]

, 2005
The α9 and α10 nicotinic cholinergic subunits assemble to form the receptor believed to mediate synaptic transmission between efferent olivocochlear fibers and hair cells of the cochlea, one of the few examples of postsynaptic function for a non-muscle ...
Arredondo, Azam, Baker, Balestra, Bleckmann, Bobbin, Boulter, Cartier, Champtiaux, Chernyavsky, Colquhoun, Conroy, Couturier, Dawkins, Deneris, Drescher, Duvoisin, Elgoyhen, Elgoyhen, Engelmann, Flock, Fuchs, Genzen, Gerzanich, Gerzanich, Glowatzki, Goldman, Gotti, Gotti, Groot-Kormelink, Guinan, Haberberger, Jones, Karlin, Katz, Katz, Kros, Kurzen, Le Novere, Lips, Luebke, Lustig, McIntosh, McIntosh, Mihovilovic, Morley, Nguyen, Nicke, Peng, Pohlmann, Rothlin, Russell, Santos, Sato, Seguela, Sgard, Terlau, Walker, Wals, Weisstaub   +59 more
core   +1 more source

Molecular basis for a pore block of Tentonin 3 expressed in HEK293 cells by a conopeptide, NMB‐1

British Journal of Pharmacology, Volume 183, Issue 9, Page 1845-1859, May 2026.
Background and Purpose Tentonin 3 (TTN3/TMEM150C) is a mechanosensitive ion channel that plays critical roles in mechanotransduction processes. TTN3 forms a tetramer with a predicted rectangular shape and a central pore. A conotoxin ρ‐TIA and its synthetic analog, noxious mechanosensation blocker 1 (NMB‐1), were initially developed to inhibit slowly ...
Sujin Lim, Junhyuk Woo, Sungmin Pak, Joonho Paik, Gyu‐Sang Hong, Ji Hun Wi, Sanghee Lee, Cristina Fenollar‐Ferrer, Kyungreem Han, Young Kee Shin, Uhtaek Oh   +10 more
wiley   +1 more source

A Polychaete’s Powerful Punch: Venom Gland Transcriptomics of Glycera Reveals a Complex Cocktail of Toxin Homologs [PDF]

, 2014
© The Author(s) 2014. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/
Abdel-Rahman, Aird, Alarcon-Chaidez, Altschul, Alves-Silva, Ambrose, Anatriello, Anderluh, Bakrac, Bakrac, Balasubramanian, Barlic, Binford, Binford, Björn M. von Reumont, Bon, Borda, Bradnam, Brinkman, Böggemann, Casewell, Castaneda, Castaneda, Chagas, Chang, Chen, Christoph Bleidorn, Conesa, Conesa, Cuypers, Dan Sykes, Darriba, De Colibus, Earl, Eddy, Fauchald, Favreau, Fernandes-Pedrosa, Francischetti, Fry, Fry, Garb, Garcia, Garcia-Ortega, Ghadessy, Giese, Giray, Grabherr, Hargreaves, He, Honma, Jungo, Jörg Hetmank, Kagan, Katoh, Kawashima, Khalturin, King, King, Kircher, Kiriake, Klawe, Kobayashi, Koua, Krebs, Kristan, Kvist, Lahcen I. Campbell, Lars Hering, Lin, Low, Low, Manaranche, Mancheno, Margres, Martin, Meunier, Meunier, Meyer, Michel, Michel, Min, Morgenstern, Morgenstern, Moses, Nakamura, Olivera, O’Neil, Peng, Pennington, Petersen, Rangaraju, Rigoni, Rokyta, Ronald A. Jenner, Rosenberg, Rouse, Safavi-Hemami, Sandy Richter, Schenning, Shiomi, Shiomi, Smeds, Stamatakis, Sukumwang, Sunagar, Terrat, Ueda, Ungerer, Violette, von Reumont, Vonk, Warren, Watala, Weston, Whittington, Wong, Zdobnov, Zhang, Zimmerberg, Zobel-Thropp   +120 more
core   +1 more source

GABAB receptor‐mediated modulation of sensory neuron excitability: Roles of CaV2.2, G‐protein‐coupled inwardly rectifying potassium (GIRK) channels, and hyperpolarisation‐activated cyclic nucleotide‐gated (HCN) channels in human and mouse nociception

Experimental Physiology, Volume 111, Issue 4, Page 2026-2043, 1 April 2026.
Abstract Chronic visceral pain is a key symptom of irritable bowel syndrome. Modulation of voltage‐gated calcium and potassium channels by G protein‐coupled receptors plays a key role in dampening nociceptive transmission. Both baclofen and the analgesic peptide α‐conotoxin Vc1.1 activate GABAB receptors (GABABR), resulting in inhibition of CaV2.2 and ...
Mariana Brizuela, Anuja R. Bony, Sonia Garcia‐Caraballo, David J. Adams, Stuart M. Brierley   +4 more
wiley   +1 more source

The introduction of marine cone snail species from the coast of the Qeshm Island, contains conotoxin palliative pain in mice [PDF]

بوم‌شناسی آبزیان, 2019
Conotoxins are small toxic peptides that are synthesized in cone snail venom ducts. Conotoxins have analgesic effects in models animal. In this study, the analgesic effects with no toxicity of Persian Gulf cone snails, Conus coronatus, and Conus frigidus
Halimeh Rajabi, Hossein Zolgharnen, Mohammad Taghi Ronagh, Ahmad Savari, Mohammad Sharif Ranjbar   +4 more
doaj  

High-Throughput Prediction and Design of Novel Conopeptides for Biomedical Research and Development

BioDesign Research, 2022
Cone snail venoms have been considered a valuable treasure for international scientists and businessmen, mainly due to their pharmacological applications in development of marine drugs for treatment of various human diseases.
Bingmiao Gao, Yu Huang, Chao Peng, Bo Lin, Yanling Liao, Chao Bian, Jiaan Yang, Qiong Shi   +7 more
doaj   +1 more source

Organic Electrochemical Transistors for Neuromorphic Devices and Applications

Advanced Materials, Volume 38, Issue 9, 12 February 2026.
Organic electrochemical transistors are emerging as promising platforms for neuromorphic devices that emulate neuronal and synaptic activities and can seamlessly integrate with biological systems. This review focuses on resultant organic artificial neurons, synapses, and integrated devices, with an emphasis on their ability to perform neuromorphic ...
Kexin Xiang, Jiajun Song, Hong Liu, Junxin Chen, Feng Yan   +4 more
wiley   +1 more source

Hyperpolarization Modulation of the T‐Type hCav3.2 Channel by Human Synenkephalin [1–53], a Shrew Neurotoxin Analogue without Paralytic Effects

Angewandte Chemie, Volume 137, Issue 27, July 1, 2025.
Human synenkephalin [1–53] (hSYN), an analogue peptide of shrew saliva neurotoxins, was synthesized and its structural characteristics studied. Synthetic hSYN potently activated the T‐type voltage‐gated Ca channel hCav3.2 but did not paralyze mealworms. These findings offer new insight into neurological disorder treatment and evolutionary mechanisms of
Ryo Fukuoka, Yusuke Yano, Nozomi Hara, Chihiro Sadamoto, Andres D. Maturana, Masaki Kita   +5 more
wiley   +2 more sources