Results 151 to 160 of about 225,321 (188)

Therapeutic Potential of Cone Snail Venom Peptides (Conopeptides)

Current Topics in Medicinal Chemistry, 2012
Cone snails have evolved many 1000s of small, structurally stable venom peptides (conopeptides) for prey capture and defense. Whilst < 0.1% have been pharmacologically characterised, those with known function typically target membrane proteins of therapeutic importance, including ion channels, transporters and GPCRs. Several conopeptides reduce pain in
Vetter, Irina, Lewis, Richard J.
openaire   +5 more sources

How Much at Risk Are Cone Snails?

Science, 2004
Jon-Paul Bingham, Thomas F Duda, Alan J. Kohn   +2 more
exaly   +2 more sources

Phyla Molluska: The Venom Apparatus of Cone Snails

2015
Predatory marine gastropods of the genus Conus comprise similar to 700 species that have evolved a highly specialized envenomation apparatus. This recently evolved genus has developed potent venoms separately for prey capture and defense. Both strategies utilize a complex but different cocktail of venom peptides that is injected through a hollow ...
Dutertre, Sebastien, Griffin, John, Lewis, Richard J.   +2 more
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Neurotoxins of Cone Snail Venoms

2002
Cone snails are predatory marine mollusks that rely on their venom components to immobilize and capture fish, worms, or other mollusks. Cones employ a number of prey-hunting strategies, ultimately involving the injection of venom through a hollow, harpoon-like, modified-tooth structure (1).
Robert Newcomb, George Miljanich
openaire   +1 more source

Novel Pharmacological Targets From Indian Cone Snails

Mini-Reviews in Medicinal Chemistry, 2011
The oceans are a source of combinatorial library of unique natural products, 'not found in the terrestrial environment'. Marine invertebrates such as sponges, molluscs, bryozoans, tunicates (Urochordata) and their associated microorganisms are the major representatives of promising bioactive compounds.
M Santhana, Ramasamy, S, Manikandan
openaire   +2 more sources

Peptide Neurotoxins from Fish-Hunting Cone Snails

Science, 1985
To paralyze their more agile prey, the venomous fish-hunting cone snails ( Conus ) have developed a potent biochemical strategy. They produce several classes of toxic peptides (conotoxins) that attack a series of successive physiological targets in the neuromuscular system of the fish.
B M, Olivera, W R, Gray, R, Zeikus, J M, McIntosh, J, Varga, J, Rivier, V, de Santos, L J, Cruz   +7 more
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Structural and biosynthetic properties of peptides in cone snail venoms

Peptides, 1995
Venoms of the predatory cone snails Conus textile, Conus striatus, and Conus magus were subjected to comprehensive analysis of peptide content. With the fish-eating cone snails C. magus and C. striatus, the most abundant venom peptides were of > 30-50 residues, whereas the predominant peptides in the venom of the mollusc-eating snail, C.
R, Newcomb, S, Gaur, J R, Bell, L, Cruz
openaire   +2 more sources

Cone Snail Venomics: From Novel Biology to Novel Therapeutics

Future Medicinal Chemistry, 2014
Peptide neurotoxins from cone snails called conotoxins are renowned for their therapeutic potential to treat pain and several neurodegenerative diseases. Inefficient assay-guided discovery methods have been replaced by high-throughput bioassays integrated with advanced MS and next-generation sequencing, ushering in the era of 'venomics'. In this review,
Prashanth, Jutty Rajan, Brust, Andreas, Jin, Ai-Hua, Alewood, Paul F., Dutertre, Sebastien, Lewis, Richard J.   +5 more
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Ichthyotoxicity caused by marine cone snail venoms?

Toxicon, 2005
Ten venoms from marine cone snails were tested for ichthyotoxic effects on zebra fish (Brachydanio rerio) when added to the water. Only two venoms, from Conus capitaneus and Conus episcopatus, produced lethal effects at high concentrations (50-300 microg/ml) within 20-90 min. No sedative or hypnotic symptoms were observed.
Dietrich, Mebs, Silke, Kauferstein
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Intraspecific variation in the venom of the vermivorous cone snail Conus vexillum

Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 2011
A combination of proteomic and biochemical assays was used to examine variations in the venom of Conus vexillum taken from two locations (Hurgada and Sharm El-Shaikh) in the Red Sea, Egypt. Using MALDI/TOF-MS, a remarkable degree of intra-species variation between venom samples from both locations was identified.
Mohamed A, Abdel-Rahman, Ismail M, Abdel-Nabi, Mohamed S, El-Naggar, Osama A, Abbas, Peter N, Strong   +4 more
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