Results 161 to 170 of about 9,402 (207)

Cone snails lure prey with faux pheromones

C&EN Global Enterprise, 2021
Cone snails use venom when hunting their prey. While much is known about the peptides in cone snail venom , the small molecules it contains have until now not been well characterized—especially in ...
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Neurotoxins of Cone Snail Venoms

2002
Cone snails are predatory marine mollusks that rely on their venom components to immobilize and capture fish, worms, or other mollusks. Cones employ a number of prey-hunting strategies, ultimately involving the injection of venom through a hollow, harpoon-like, modified-tooth structure (1).
Robert Newcomb, George Miljanich
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Ichthyotoxicity caused by marine cone snail venoms?

Toxicon, 2005
Ten venoms from marine cone snails were tested for ichthyotoxic effects on zebra fish (Brachydanio rerio) when added to the water. Only two venoms, from Conus capitaneus and Conus episcopatus, produced lethal effects at high concentrations (50-300 microg/ml) within 20-90 min. No sedative or hypnotic symptoms were observed.
Dietrich, Mebs, Silke, Kauferstein
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From a Cone Snail Toxin to a Competitive MC4R Antagonist

Journal of Medicinal Chemistry, 2022
The melanocortin 4 receptor (MC4R) plays a role in energy homeostasis and represents a target for treating energy balance disorders. For decades, synthetic ligands have been derived from MC4R endogenous agonists and antagonists, such as setmelanotide used to treat rare forms of genetic obesity.
Reynaud, Steve, Laurin, Suli-Anne, Ciolek, Justyna, Barbe, Peggy, van Baelen, Anne-Cécile, Susset, Michaël, Blondel, Florian, Ghazarian, Marine, Boeri, Julia, Vanden Driessche, Margot, Upert, Grégory, Mourier, Gilles, Kessler, Pascal, Konnert, Laure, Beroud, Rémy, Keck, Mathilde, Servent, Denis, Bouvier, Michel, Gilles, Nicolas   +18 more
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Cone Snail Venomics: From Novel Biology to Novel Therapeutics

Future Medicinal Chemistry, 2014
Peptide neurotoxins from cone snails called conotoxins are renowned for their therapeutic potential to treat pain and several neurodegenerative diseases. Inefficient assay-guided discovery methods have been replaced by high-throughput bioassays integrated with advanced MS and next-generation sequencing, ushering in the era of 'venomics'. In this review,
Prashanth, Jutty Rajan, Brust, Andreas, Jin, Ai-Hua, Alewood, Paul F., Dutertre, Sebastien, Lewis, Richard J.   +5 more
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Piscivorous Behavior of a Temperate Cone Snail,Conus californicus

The Biological Bulletin, 2005
Most of the more than 500 species of predatory marine snails in the genus Conus are tropical or semitropical, and nearly all are thought to be highly selective regarding type of prey. Conus californicus Hinds, 1844, is unusual in that it is endemic to the North American Pacific coast and preys on a large variety of benthic organisms, primarily worms ...
Julia, Stewart, William F, Gilly
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Pharmacology of predatory and defensive venom peptides in cone snails

Molecular BioSystems, 2017
Cone snails use distinct venoms for defence and prey capture. The pharmacology of these neurotoxic peptides have been extensively studied for pharmacological probes, venom evolution mechanisms and potential therapeutics.
Jutty Rajan Prashanth, Sebastien Dutertre, Richard James Lewis   +2 more
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Venomic study on cone snails (Conus spp.) from South Africa

Toxicon, 2011
From six Conus species (Conus coronatus, Conus lividus, Conus mozambicus f. lautus, Conus pictus, Conus sazanka, Conus tinianus) collected off the eastern coast of South Africa the venoms were analyzed using MALDI-TOF mass spectrometry. Between 56 and 151 molecular masses most in a range of 1000 to 2500 Da, were identified.
Kauferstein, S., Porth, C., Kendel, Y., Wunder, C., Nicke, A., Kordis, D., Favreau, P., Koua, D., Stoecklin, R., Mebs, D.   +9 more
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Structural and biosynthetic properties of peptides in cone snail venoms

Peptides, 1995
Venoms of the predatory cone snails Conus textile, Conus striatus, and Conus magus were subjected to comprehensive analysis of peptide content. With the fish-eating cone snails C. magus and C. striatus, the most abundant venom peptides were of > 30-50 residues, whereas the predominant peptides in the venom of the mollusc-eating snail, C.
R, Newcomb, S, Gaur, J R, Bell, L, Cruz
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Phyla Molluska: The Venom Apparatus of Cone Snails

2015
Predatory marine gastropods of the genus Conus comprise similar to 700 species that have evolved a highly specialized envenomation apparatus. This recently evolved genus has developed potent venoms separately for prey capture and defense. Both strategies utilize a complex but different cocktail of venom peptides that is injected through a hollow ...
Dutertre, Sebastien, Griffin, John, Lewis, Richard J.   +2 more
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