Results 1 to 10 of about 337,623 (298)

Covalent conjugation of extracellular vesicles with peptides and nanobodies for targeted therapeutic delivery

Journal of Extracellular Vesicles, 2021
Natural extracellular vesicles (EVs) are ideal drug carriers due to their remarkable biocompatibility. Their delivery specificity can be achieved by the conjugation of targeting ligands.
Tin Chanh Pham, Migara Kavishka Jayasinghe, Thach Tuan Pham, Yuqi Yang, Likun Wei, Waqas Muhammad Usman, Huan Chen, Marco Pirisinu, Jinhua Gong, Seongkyeol Kim, Boya Peng, Weixi Wang, Charlene Chan, Victor Ma, Nhung T.H. Nguyen, Dennis Kappei, Xuan‐Hung Nguyen, William C. Cho, Jiahai Shi, Minh T.N. Le   +19 more
doaj   +2 more sources

Ubiquitin-like conjugation by bacterial cGAS enhances anti-phage defence

Nature, 2023
Cap2 of the cyclic dinucleotide-based anti-phage immune system functions through a ubiquitin-like conjugation mechanism to regulate cGAS activity. cGAS is an evolutionarily conserved enzyme that has a pivotal role in immune defence against infection^ 1 –
J. Jenson, Tuo Li, Fenghe Du, Chee-Kwee Ea, Zhijian J. Chen   +4 more
semanticscholar   +1 more source

Attenuating metal-substrate conjugation in atomically dispersed nickel catalysts for electroreduction of CO2 to CO

Nature Communications, 2022
Atomically dispersed transition metals on carbon-based aromatic substrates are an emerging class of electrocatalysts for the electroreduction of CO_2. However, electron delocalization of the metal site with the carbon support via d-π conjugation strongly
Qiyou Wang, Kang Liu, Kangman Hu, Chaoyang Cai, Huangjingwei Li, Hong-mei Li, M. Herran, Ying-Rui Lu, Ting-Shan Chan, Chao Ma, Jun Fu, Shiguo Zhang, Ying Liang, E. Cortes, Min Liu   +14 more
semanticscholar   +1 more source

A degradative to secretory autophagy switch mediates mitochondria clearance in the absence of the mATG8-conjugation machinery

Nature Communications, 2022
PINK1-Parkin mediated mitophagy, a selective form of autophagy, represents one of the most important mechanisms in mitochondrial quality control (MQC) via the clearance of damaged mitochondria.
Hayden Weng Siong Tan, Guang Lu, Han Dong, Yik-Lam Cho, Auginia Natalia, Liming Wang, Charlene Chan, Dennis Kappei, R. Taneja, Shuo-Chien Ling, Huilin Shao, Shih-Yin Tsai, W. Ding, Hanming Shen   +13 more
semanticscholar   +1 more source

Organic fluorophores that emit ultraviolet light in the aggregated state

Aggregate, 2022
Ultraviolet (UV)‐emissive organic light‐emitting diodes (OLEDs) have attracted growing attention as future UV‐lighting sources following UV‐LED. The design and development of highly efficient UV‐emissive organic solids are essential for the advancement ...
Masaki Shimizu, Tsuneaki Sakurai
doaj   +1 more source

Glutathione-Mediated Conjugation of Anticancer Drugs: An Overview of Reaction Mechanisms and Biological Significance for Drug Detoxification and Bioactivation

Molecules, 2022
The effectiveness of many anticancer drugs depends on the creation of specific metabolites that may alter their therapeutic or toxic properties.
Agnieszka Potęga
semanticscholar   +1 more source

Native size-exclusion chromatography-mass spectrometry: suitability for antibody–drug conjugate drug-to-antibody ratio quantitation across a range of chemotypes and drug-loading levels

mAbs, 2020
Native size-exclusion chromatography-mass spectrometry (nSEC-MS) is an analytical methodology that is appropriate for accurately quantitating the drug-to-antibody ratio (DAR) on a wide variety of interchain cysteine-linked antibody-drug conjugates (ADCs),
Jay Jones, Laura Pack, Joshua H. Hunter, John F. Valliere-Douglass   +3 more
doaj   +1 more source

Conjugative IncC Plasmid Entry Triggers the SOS Response and Promotes Effective Transfer of the Integrative Antibiotic Resistance Element SGI1

Microbiology Spectrum, 2023
The broad-host-range IncC plasmid family and the integrative mobilizable Salmonella genomic island 1 (SGI1) and its derivatives enable the spread of medically important antibiotic resistance genes among Gram-negative pathogens.
Marine C. Pons, Karine Praud, Sandra Da Re, Axel Cloeckaert, Benoît Doublet   +4 more
doaj   +1 more source

Origins of transfer establish networks of functional dependencies for plasmid transfer by conjugation

Nucleic Acids Research, 2022
Plasmids can be transferred between cells by conjugation, thereby driving bacterial evolution by horizontal gene transfer. Yet, we ignore the molecular mechanisms of transfer for many plasmids because they lack all protein-coding genes required for ...
Manuel Ares-Arroyo, Charles Coluzzi, Eduardo P C Rocha   +2 more
semanticscholar   +1 more source

RcgA and RcgR, Two Novel Proteins Involved in the Conjugative Transfer of Rhizobial Plasmids

mBio, 2022
Rhizobia are Gram-negative bacteria that are able to establish a nitrogen-fixing symbiotic interaction with leguminous plants. Rhizobia genomes usually harbor several plasmids which can be transferred to other organisms by conjugation.
Lucas G. Castellani, Abril Luchetti, Juliet F. Nilsson, Julieta Pérez-Giménez, Ben Struck, Andreas Schlüter, Alfred Pühler, Karsten Niehaus, David Romero, Mariano Pistorio, Gonzalo Torres Tejerizo   +10 more
doaj   +1 more source