Results 31 to 40 of about 337,623 (298)

Foodborne Microbial Communities as Potential Reservoirs of Antimicrobial Resistance Genes for Pathogens: A Critical Review of the Recent Literature

Microorganisms, 2023
Antimicrobial resistance (AMR) is a global and increasing threat to human health. Several genetic determinants of AMR are found in environmental reservoirs, including bacteria naturally associated with widely consumed fermented foods.
Paola Zinno, Giuditta Perozzi, Chiara Devirgiliis   +2 more
doaj   +1 more source

Reducing Antigenicity and Improving Antioxidant Capacity of β-Lactoglobulin through Covalent Interaction with Six Flavonoids

Foods, 2023
β-lactoglobulin (β-LG) is a pivotal nutritional and functional protein. However, its application is limited by its antigenicity and susceptibility to oxidation.
Pei Pu, Zhifen Deng, Lang Chen, Han Yang, Guizhao Liang   +4 more
doaj   +1 more source

Enhancing the Activity of Drugs by Conjugation to Organometallic Fragments

Chemistry, 2020
Resistance to chemotherapy is a current clinical problem, especially in the treatment of microbial infections and cancer. One strategy to overcome this is to make new derivatives of existing drugs by conjugation to organometallic fragments, either by an ...
P. Chellan, P. Sadler
semanticscholar   +1 more source

Structural and Biochemical Analysis of OrfG: The VirB8-like Component of the Conjugative Type IV Secretion System of ICESt3 From Streptococcus thermophilus

Frontiers in Molecular Biosciences, 2021
Conjugative transfer is a major threat to global health since it contributes to the spread of antibiotic resistance genes and virulence factors among commensal and pathogenic bacteria.
Julien Cappele, Abbas Mohamad Ali, Nathalie Leblond-Bourget, Sandrine Mathiot, Tiphaine Dhalleine, Sophie Payot, Martin Savko, Claude Didierjean, Frédérique Favier, Badreddine Douzi   +9 more
doaj   +1 more source

Antibody-drug conjugates: recent advances in conjugation and linker chemistries

Protein & Cell, 2016
The antibody-drug conjugate (ADC), a humanized or human monoclonal antibody conjugated with highly cytotoxic small molecules (payloads) through chemical linkers, is a novel therapeutic format and has great potential to make a paradigm shift in cancer ...
K. Tsuchikama, Z. An
semanticscholar   +1 more source

Effect of donor-recipient relatedness on the plasmid conjugation frequency: a meta-analysis

BMC Microbiology, 2020
Background Conjugation plays a major role in the transmission of plasmids encoding antibiotic resistance genes in both clinical and general settings.
Jesse B. Alderliesten, S. Duxbury, M. Zwart, J. de Visser, A. Stegeman, Egil A. J. Fischer   +5 more
semanticscholar   +1 more source

Aptamers Chemistry: Chemical Modifications and Conjugation Strategies

Molecules, 2019
Soon after they were first described in 1990, aptamers were largely recognized as a new class of biological ligands that can rival antibodies in various analytical, diagnostic, and therapeutic applications.
F. Odeh, Hamdi Nsairat, W. Alshaer, M. Ismail, Ezaldeen Esawi, B. Qaqish, A. Bawab, S. Ismail   +7 more
semanticscholar   +1 more source

Capture of mobile genetic elements following intercellular conjugation promotes the production of ST11-KL64 CR-hvKP

Microbiology Spectrum
Sequence type (ST)11 carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) can cause life-threatening infections and is therefore of global concern.
Shanshan Huang, Dan Dan Wei, Hanxu Hong, Si Chen, Lin-Ping Fan, Qi-Sen Huang, Fang-Ling Du, Tian-Xin Xiang, Ping Li, Wei Zhang, La-Gen Wan, Yang Liu   +11 more
doaj   +1 more source

Ubiquitin-like Protein Conjugation: Structures, Chemistry, and Mechanism

Chemical Reviews, 2017
Ubiquitin-like proteins (Ubl’s) are conjugated to target proteins or lipids to regulate their activity, stability, subcellular localization, or macromolecular interactions.
L. Cappadocia, C. Lima
semanticscholar   +1 more source

Variation on a theme; an overview of the Tn916 / Tn1545 family of mobile genetic elements in the oral and nasopharyngeal streptococci.

Frontiers in Microbiology, 2014
The oral and nasopharyngeal streptococci are a major part of the normal microbiota in humans. Most human associated streptococci are considered commensals however a small number of them are pathogenic, causing a wide range of diseases including oral ...
Francesco eSantoro, Morgana Eli Vianna, Adam Paul Roberts   +2 more
doaj   +1 more source