Results 21 to 30 of about 26,063 (225)
Connexin 43 signalling and cardioprotection [PDF]
Heart, 2005 Connexin (Cx) 43 is the predominant protein forming gap junctions and non-junctional hemichannels in ventricular myocardium. The Cx43 proteins are central to the cardioprotection afforded by ischaemic preconditioning (IP). The specific role of mitochondrial C×43 in protection by IP is reviewed.
K, Boengler, R, Schulz, G, Heusch
openaire +2 more sources
Identification of Connexin-43 Interacting Proteins [PDF]
Cell Communication & Adhesion, 2003 Connexin-43 (Cx43), the most ubiquitously expressed vertebrate gap junction protein, has been shown to interact directly with Zonula Occludens-1 (ZO-1). Although several potential functions have been proposed for the ZO-1/Cx43 interaction, the role that ZO-1 and other Cx43-interacting partners play in the regulation of Cx43 trafficking, assembly ...
Deepika, Singh, Paul D, Lampe
openaire +2 more sources
Cardiac mitochondrial connexin 43 regulates apoptosis [PDF]
Biochemical and Biophysical Research Communications, 2007 Connexin 43 (Cx43) is thought to be present largely in the plasma membrane and its function solely to provide low resistance electrical connection between myocytes. A recent report suggested the presence of Cx43 in the mitochondria as well. We confirmed the presence of Cx43 in the mitochondria isolated from adult rat ventricles with the Cx43 ...
Farida, Goubaeva +5 more
openaire +2 more sources
Postępy Higieny i Medycyny Doświadczalnej, 2020 Skeleton formation and its proper functioning is possible thanks to specialized bone tissue cells: bone forming osteoblasts, bone resorbing osteoclasts and osteocytes located in bone cavities. Gap junctions are transmembrane channels connecting neighboring cell. Thanks to gap junctions it is possible for signals to be directly transmitted by cells. Gap
Krzysztof Łukowicz +3 more
openaire +1 more source
Connexin 43 reduces susceptibility to sympathetic atrial fibrillation
International Journal of Molecular Medicine, 2018 Atrial fibrillation (AF) is the most common arrhythmia reported in clinical practice. Connexin 43 (Cx43) is a member of the connexin protein family, which serves important roles in signal transduction in vivo. The aim of the present study was to investigate the role of Cx43 in the induction and maintenance of atrial fibrillation by using an animal ...
Beibei Luo +9 more
openalex +5 more sources
Connexin 43 Hemichannels Are Permeable to ATP [PDF]
The Journal of Neuroscience, 2008 Astrocytes are electrically nonexcitable cells that communicate by means of Ca2+signaling. Long-distance intercellular Ca2+waves are initiated by release of ATP and activation of purinergic receptors on nearby cells. Previous studies have implicated connexin 43 (Cx43) in ATP release, but definitive proof that ATP exits through Cx43 hemichannels does ...
Jian Kang +6 more
openalex +4 more sources
Astroglial connexin 43 sustains glutamatergic synaptic efficacy [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2014 Astrocytes dynamic interactions with neurons play an active role in neurotransmission. The gap junction (GJ) subunits connexins 43 and 30 are strongly expressed in astrocytes and have recently been shown to regulate synaptic activity and plasticity.
Chever, Oana +3 more
openaire +4 more sources
Connexin-43-dependent ATP release mediates macrophage activation during sepsis
eLife, 2019 Bacterial spillage into a sterile environment following intestinal hollow-organ perforation leads to peritonitis and fulminant sepsis. Outcome of sepsis critically depends on macrophage activation by extracellular ATP-release and associated autocrine ...
Michel Dosch +7 more
doaj +1 more source
BMC Medicine, 2008 Background The modulation of gap junctional communication between tumor cells and between tumor and vascular endothelial cells during tumorigenesis and metastasis is complex.
Gillespie Mark N +5 more
doaj +1 more source
Journal of Experimental & Clinical Cancer Research, 2010 Background bFGF is an important growth factor for glioma cell proliferation and invasion, while connexin 43 is implicated in the suppression of glioma growth.
Liu Hongsheng +5 more
doaj +1 more source