Results 61 to 70 of about 26,063 (225)

Expression of Connexin 32 and Connexin 43 gap junction proteins in basal and squamous cell carcinomas

Medicine Science, 2023
Gap junctions play a role in intercellular communication in the epithelium, muscle and nerve tissues, and many more tissues and organs. These linking regions and the proteins forming them are called connexins (Cx).
Havva Erdem, Muruvvet Akcay Celik, Arzu Sahin, Nurten Turhan Haktanir   +3 more
doaj   +1 more source

Metabolic and biochemical profiling reveals phenotypic heterogeneity in Zucker diabetic fatty rats

Animal Models and Experimental Medicine, EarlyView.
Genetically uniform Zucker Diabetic Fatty (ZDF) rats spontaneously develop four distinct metabolic phenotypes despite identical housing and diet conditions. Each phenotype exhibits unique biomarker signatures encompassing glucose homeostasis, insulin secretion, polyol pathway activation, oxidative stress, inflammatory cytokines, and neurotrophic ...
Marek Lepáček, Pavol Boďo, Barbora Kaločayová, Marta Šoltésová Prnová   +3 more
wiley   +1 more source

Connexin 43: Key roles in the skin

Biomedical Reports, 2017
Gap junctions are tightly packed intercellular channels that serve a common purpose of allowing the intercellular exchange of small metabolites, second messengers and electrical signals. Connexins (Cxs) are gap junction proteins. Currently, 20 and 21 members of Cxs have been characterized in mice and humans, respectively. Connexin 43 (Cx43) is the most
Xiao-Fei, Zhang, Xiaofeng, Cui
openaire   +3 more sources

Role of soft tissue and bone interactions in the developmental integration and modularity of the skull in neural crest‐specific gap junction alpha‐1 knockout mice

The Anatomical Record, EarlyView.
Abstract The vertebrate skull is composed of bones derived from neural crest cells and mesoderm. The evolutionary capacity of the skull has been linked, in part, to the emergence of neural crest cells; however, this increased capacity for evolutionary change requires that variation within neural crest‐ and mesoderm‐derived bones remains partly ...
Alyssa C. Moore, Madeline Tourigny, Diana Quinonez, Kevin Barr, Matthew W. Grol, Katherine E. Willmore   +5 more
wiley   +1 more source

Biomaterial design strategies for enhancing mitochondrial transplantation therapy

BMEMat, EarlyView.
Biomaterials to facilitate mitochondrial transplantation therapy: biomaterials as barriers to protect mitochondria from pathophysiological microenvironments, like osmotic stress caused by the excessive concentration of calcium ion, reactive oxygen species, and advanced glycation end products; biomaterials integrating with biochemical cues to improve ...
Shaoyang Kang, Yushan Zhang, Hang Li, Sirui Peng, Donghao Lyu, Chunxiao Zhou, Sheng Ding, Zujian Feng, Pingsheng Huang, Chuangnian Zhang, Hongjun Wang, Deling Kong, Weiwei Wang   +12 more
wiley   +1 more source

Bone-Resorbing Osteoclasts Contain Gap-Junctional Connexin-43 [PDF]

Journal of Bone and Mineral Research, 2000
Abstract Intercellular gap junctions have been previously described at contact sites between surface osteoblasts, between osteoblasts and underlying osteocytes, and between osteocyte cell processes in the canaliculi. The subunits of gap junction channels are assembled from a family of proteins called connexins.
J, Ilvesaro, K, Väänänen, J, Tuukkanen   +2 more
openaire   +2 more sources

Influence of Berberine on Cisplatin Antineoplastic Effect in A549 Cells

Chinese Journal of Lung Cancer, 2015
Background and objective Cisplatin is a standard first-line chemotherapeutic agents for treating advanced non-small cell lung cancer. Unfortunately, the clinical application cisplatin is restricted because it induces serious adverse reaction.
Guojun JIANG, Li LI, Xiaoxiang WU, Shuying DONG, Xuhui TONG   +4 more
doaj   +1 more source

Role of astroglial hemichannels and pannexons in Memory and Neurodegenerative diseases

Frontiers in Integrative Neuroscience, 2016
Under physiological conditions, astroglial hemichannels and pannexin channels allow the release of gliotransmitters from astrocytes. These gliotransmitters are critical in modulating synaptic transmission, plasticity and memory.
Juan Andrés Orellana, Mauricio Antonio Retamal, Rodrigo Moraga Amaro, Jimmy Stehberg   +3 more
doaj   +1 more source

CX43 down-regulation promotes cell aggressiveness and 5-fluorouracil-resistance by attenuating cell stiffness in colorectal carcinoma

Cancer Biology & Therapy, 2023
Chemotherapy is one of the most commonly treatments of advanced colorectal cancer (CRC). However, the drug resistant following chemotherapeutic treatment is a significant challenge in the clinical management of CRC.
Yue Han, Haowei Wang, Hui Chen, Tianyuan Tan, Yiqing Wang, Hongjun Yang, Yanqing Ding, Shuang Wang   +7 more
doaj   +1 more source

Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases

BMEMat, EarlyView.
This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou, Jia Liu, Shulin Lai, Suhan Yin, Bingmin Luo, Longquan Shao, Yiyuan Kang   +6 more
wiley   +1 more source