Results 91 to 100 of about 854 (148)

2-aminoethoxydiphenyl borate directly inhibits channels composed of connexin26 and/or connexin32. [PDF]

, 2007
2-Aminoethoxydiphenyl borate (2-APB), a commonly used blocker of IP 3 -induced calcium ion release and of store-operated channels, inhibits gap junction conductance when applied to cultured cells.
Liang Tao, Andrew L Harris
core  

Different Regulation of Connexin26 and ZO-1 in Cochleas of Developing Rats and of Guinea Pigs with Endolymphatic Hydrops

, 2001
Using confocal microscopy and morphometry, we analyzed the expression of connexin26 (Cx26) and ZO-1 in rat cochlea during the postnatal period to elucidate spatiotemporal changes in gap junctions and tight junctions during auditory development.
Tetsuro Takamatsu, Toshihiro Suzuki, Oyamada Masahito   +2 more
core   +1 more source

Research article

, 2007
Background: In order to further distinguish unique from general functions of connexin43, we have generated mice in which the coding region of connexin43 was replaced by that of connexin26.Results: Heterozygous mothers showed impaired mammary gland ...
Freyer, Jennifer, Urschel, Stephanie, Lewalter, Thorsten, Maass, Karen, Pielensticker, Nicole, Tiemann, Klaus, Willecke, Klaus, Winterhager, Elke, Kim, Jung-Sun, Ghanem, Alexander, Simoni, Manuela, Behr, Rüdiger, Grümmer, Ruth, Schrickel, Jan W.   +13 more
core   +1 more source

Limited Impact of Murine Placental MDR1 on Fetal Exposure of Certain Drugs Explained by Bypass Transfer Between Adjacent Syncytiotrophoblast Layers. [PDF]

Pharm Res, 2022
Fujita A, Noguchi S, Hamada R, Inoue S, Shimada T, Katakura S, Maruyama T, Sai Y, Nishimura T, Tomi M.   +9 more
europepmc   +1 more source

Editorial: The mechanism on development and regeneration of inner ear hair cells. [PDF]

Front Mol Neurosci, 2022
Sun H, Chen B, Sun Y, Li H, Ren D.
europepmc   +1 more source

A missense mutation in connexin26, D66H, causes mutilating keratoderma with sensorineural deafness (Vohwinkel's syndrome) in three unrelated families.

, 1999
The multiplicity of functions served by intercellular gap junctions is reflected by the variety of phenotypes caused by mutations in the connexins of which they are composed. Mutations in the connexin26 (Cx26) gene ( GJB2 ) at 13q11-q13 are a major cause
Cambiaghi, S, Monaco, Anthony, Korge, BP, Munro, CS, Hovnanian, A, Maestrini, E, Monaco, AP, Ocaña-Sierra, J, Calzolari, E, Scudder, PM   +9 more
core   +1 more source

Serum connexin 26 as a potential marker of non-syndromic hearing loss

The Egyptian Journal of Otolaryngology
Background Hearing loss (HL) represents the most common form of sensory impairment in both children and adults. In children, genetic causes account for over 50%. The genetic causes of HL include multiple syndromes associated with HL.
Hend M. Moness, Noha M. Abdullah, Doaa El Amrousy, Reham Gamal, Hatem A. Mohamed, Mohammed A. Gomaa, Shaimaa Moustafa Hafez, Zamzam Hassan Mohamed   +7 more
doaj   +1 more source

Super-resolution structured illumination fluorescence microscopy of the lateral wall of the cochlea : the Connexin26/30 proteins are separately expressed in man

, 2016
Globally 360 million people have disabling hearing loss and, of these, 32 million are children. Human hearing relies on 15,000 hair cells that transduce mechanical vibrations to electrical signals in the auditory nerve. The process is powered by the endo-
Schrott-Fischer, Annelies,, Laurell, Göran,, Magnusson, Peetra,, Edin, Fredrik,, Li, Hao,, Rask-Andersen, Helge,, Glueckert, Rudolf,, Liu, Wei,, Blom, Hans,, Santi, Peter A.,   +9 more
core   +1 more source

A Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) test to Detect the Common Mutation (35delG) in the Connexin-26 Gene

Sultan Qaboos University Medical Journal, 2001
Objective: To develop a polymerase chain reaction (PCR) based test for the detection of a common frame-shift mutation (35delG) in the connexin-26 (GJB2) gene, and to investigate the status of this mutation in Oman.
Mehmet Simsek, Nadia Al-Wardy, Mazin Al-Khabory   +2 more
doaj  

Phenotypic Heterogeneity of Post-lingual and/or Milder Hearing Loss for the Patients With the GJB2 c.235delC Homozygous Mutation. [PDF]

Front Cell Dev Biol, 2021
Wang H, Gao Y, Guan J, Lan L, Yang J, Xiong W, Zhao C, Xie L, Yu L, Wang D, Wang Q.   +10 more
europepmc   +1 more source