The Effects of Calcium on Nf-Κb Pathway in Hacat Cells Containing Connexin26 Kid Syndrome Mutations
, 2023 Keratitis-ichthyosis-deafness (KID) syndrome is a rare genetic disorder characterized by deafness, corneal defects, and thickened, scaly skin and associated with mutations in Connexin26 (Cx26), resulting in the formation of hyperactive hemichannels that ...
Yaşarbaş, Sümeyye Şüheda
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Connexin26 Gap Junction Mediates miRNA Intercellular Genetic Communication in the Cochlea and Is Required for Inner Ear Development [PDF]
, 2015 Organ development requires well-established intercellular communication to coordinate cell proliferations and differentiations. MicroRNAs (miRNAs) are small, non-coding RNAs that can broadly regulate gene expression and play a critical role in the organ ...
Zong, Liang +3 more
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Atomic Force Microscopy Shows Connexin26 Hemichannel Clustering in Purified Membrane Fragments [PDF]
, 2014 Connexin proteins form hexameric assemblies known as hemichannels. When docked to form gap junction (GJ) channels, hemichannels play a critical role in cell-cell communication and cellular homeostasis, but often are functional entities on their own in ...
Lal, Ratnesh +11 more
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Upsala Journal of Medical Sciences, 2017 Background: Mutations in the GJB2 gene, which encodes the Connexin26 (Cx26) protein, are the most common cause of childhood hearing loss in American and European populations.
Wei Liu +9 more
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Cyclic nucleotide permeability through unopposed connexin hemichannels
Frontiers in Pharmacology, 2013 Cyclic AMP is a well-known intracellular and intercellular second messenger. The membrane permeability of such molecules has potential importance for autocrine like or paracrine-like delivery.
Virginijus eValiunas
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Expression of Gap Junction Protein Connexin43 in the Adult Rat Cochlea: Comparison with Connexin26
, 2003 To elucidate whether the two different gap junction proteins connexin43 (Cx43) and connexin26 (Cx26) are expressed and localized in a similar manner in the adult rat cochlea, we performed three-dimensional confocal microscopy using cryosections and ...
Tetsuro Takamatsu +2 more
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, 1994 We investigated the expression of gap junctions in virgin, pregnant, lactating, and involuting mouse mammary gland epithelium with a panel of sequence-specific antibodies to connexins 26, 32, 40 and 43.
G Carlile +7 more
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A novel GJB2 mutation p.Asn54His in a patient with palmoplantar keratoderma, sensorineural hearing loss and knuckle pads [PDF]
, 2007 Mutations in the GJB2 gene encoding connexin26 are the major cause of autosomal-recessive or -dominant nonsyndromic congenital sensorineural hearing loss (SNHL) (Kelsell et al., 1997; Kenneson et al., 2002; refer to the connexin-deafness homepage at http:
Masashi Akiyama +19 more
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CO2 directly modulates connexin 26 by formation of carbamate bridges between subunits [PDF]
, 2013 Homeostatic regulation of the partial pressure of CO2 (PCO2) is vital for life. Sensing of pH has been proposed as a sufficient proxy for determination of PCO2 and direct CO2-sensing largely discounted.
Greenhalgh, S.A. +18 more
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Towards an understanding of the role of Connexin26 in breathing [PDF]
Connexin26 (Cx26) hemichannels expressed in glia at the ventral medullary surface (VMS) have been proposed to play a role in respiratory chemoreception, although this is disputed. At the VMS Cx26 hemichannels open in response to CO2 directly, causing ATP
van de Wiel, Joseph
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