Results 101 to 110 of about 2,702,233 (230)

Connexin-43 (Cx43) channels do not mediate the mean event probability.

, 2019
(A) Localization of Cx43 (white in the Cx43 only image, yellow in the composite image). Cells were counter-stained with rhodamine phalloidin (red) and DAPI (blue).
Sung Jun Son (6631073), Yoonjoo Lee (6631064), Min Tae Kim (4856773), Vickery Trinkaus-Randall (136486), Garrett Rhodes (6631067), Christopher V. Gabel (105542), Vijaya B. Kolachalama (256506), Kelsey Sack (6631070), Celeste B. Rich (136484)   +8 more
core   +1 more source

An age‐associated decline in the role of the sarcoplasmic reticulum and associated calcium‐handling proteins sets the pace for sinoatrial node function

The Journal of Physiology, EarlyView.
Abstract figure legend Stable, responsive pacemaking in the sinoatrial node is driven by the activity of the funny current (membrane clock), interplay of calcium cycling and release from the sarcoendoplasmic reticulum with depolarising sodium‐calcium exchange current (calcium clock). With increasing age, key proteins associated with calcium cycling are
Sandra A. Jones, Fiona S. Godbeer, Matthew K. Lancaster   +2 more
wiley   +1 more source

Longer action potential duration in the Purkinje network than in the ventricular myocardium delays retrograde activation of the human His‐Purkinje system

The Journal of Physiology, EarlyView.
Abstract figure legend Activation time (AT) maps from right ventricular apical pacing in a human ventricles model with longer action potential duration in the His‐Purkinje system (HPS) than in the myocardium (MYO). For pacing with a long S1S2 coupling interval (CI), the AT from the myocardial pacing site to the first AT of the HPS (ATMYO) is longer ...
Jason D. Bayer, Edward J. Vigmond, Ruben Coronel, Chantal E. Conrath   +3 more
wiley   +1 more source

A Case Report of Keratoderma and Bilateral Deafness

پزشکی بالینی ابن سینا, 2014
Introduction: Various inherited or acquired disorders are characterized by palmoplantar kera-toderma hyperkeratosis of hands and feet, and when accompanied with deafness indicates mutations in the gene encoding connexin -26 or a particular mutation ...
Gholamreza Eshghi, Heshmatollah Babaie, Hasan Faghani   +2 more
doaj  

Frequency of GJB2 mutations, GJB6‐D13S1830 and GJB6‐D13S1854 deletions among patients with non‐syndromic hearing loss from the central region of Iran

Molecular Genetics & Genomic Medicine, 2019
Background In the present study, we investigate the prevalence of the GJB2 gene mutations, and deletions in the GJB6 gene, namely del (GJB6‐D13S1830) and del (GJB6‐D13S1854), in patients with autosomal recessive non‐syndromic hearing loss (ARNSHL) from ...
Hossein Naddafnia, Zahra Noormohammadi, Shiva Irani, Iman Salahshoorifar   +3 more
doaj   +1 more source

Cellular and deafness mechanisms underlying connexin mutation induced hearing loss – A common hereditary deafness

Frontiers in Cellular Neuroscience, 2015
Hearing loss due to mutations in the connexin gene family which encodes gap junctional proteins is a common form of hereditary deafness. In particular, connexin 26 (Cx26, GJB2) mutations are responsible for ~50% of nonsyndromic hearing loss, which is the
Jeffrey C Wingard, Hong-Bo eZhao
doaj   +1 more source

Age‐ and sex‐specific modulation of human cardiac electrophysiology by doxorubicin

The Journal of Physiology, EarlyView.
Abstract figure legend DOX differentially impacts cardiac electrophysiology based on sex and age. Sex differences were primarily observed among younger hearts, where action potential duration (APD) prolongation was observed in females, but not in males. Created using BioRender. George, S. (2026) https://BioRender.com/wresf1k Abstract Acute doxorubicin (
Sharon A. George, Amber V. Mills, Erin O'Neill, Sofian N. Obaid, Igor R. Efimov, Tatiana Efimova   +5 more
wiley   +1 more source

A Human-Derived Monoclonal Antibody Targeting Extracellular Connexin Domain Selectively Modulates Hemichannel Function

Frontiers in Physiology, 2019
Connexin hemichannels, which are plasma membrane hexameric channels (connexons) composed of connexin protein protomers, have been implicated in a host of physiological processes and pathological conditions. A number of single point pathological mutations
Gaia Ziraldo, Gaia Ziraldo, Damiano Buratto, Yuanyuan Kuang, Liang Xu, Andrea Carrer, Andrea Carrer, Chiara Nardin, Chiara Nardin, Francesco Chiani, Anna Maria Salvatore, Gaetano Paludetti, Gaetano Paludetti, Richard A. Lerner, Guang Yang, Francesco Zonta, Fabio Mammano, Fabio Mammano, Fabio Mammano   +18 more
doaj   +1 more source

Molekularbiologische und physiologische Untersuchung von Connexin-Halbkanälen in Atemwegsepithelzellen nach Adenosinrezeptorstimulierung

, 2023
Sowohl die Freisetzung von Adenosin als auch die Aktivität von Connexin-Halbkanälen werden mit pathologischen Ereignissen in der Lunge, wie Entzündun-gen, in Verbindung gebracht.
Dierks, Anne
core   +1 more source

Electrophysiological properties of the dorsal motor nucleus of the vagus motoneurones controlling airway mucus secretion in rats

The Journal of Physiology, EarlyView.
Abstract figure legend Acidosis depolarises parasympathetic respiratory motoneurones in the dorsal motor nucleus of the vagus (DMV) and increases their firing frequency by reducing TWIK‐2 channel conductance. Acidosis also activates astrocytes, which further enhance neuronal excitability through NMDA receptor‐dependent glutamatergic signalling.
Daniel P. de Souza, Renato W. Martins Sá, Luiza Henrique de Souza, Fernando S. Ramalho, Davi J. A. Moraes   +4 more
wiley   +1 more source