Results 111 to 120 of about 2,702,233 (230)
Scientific Reports, 2017 We have previously shown that in vitro transduction with bovine adeno–associated viral (BAAV) vectors restores connexin expression and rescues gap junction coupling in cochlear organotypic cultures from connexin–deficient mice that are models DFNB1 ...
Giulia Crispino +7 more
doaj +1 more source
DFNB1 Non-syndromic Hearing Impairment: Diversity of Mutations and Associated Phenotypes
Frontiers in Molecular Neuroscience, 2017 The inner ear is a very complex sensory organ whose development and function depend on finely balanced interactions among diverse cell types. The many different kinds of inner ear supporting cells play the essential roles of providing physical and ...
Francisco J. del Castillo +3 more
doaj +1 more source
Journal of the Peripheral Nervous System, Volume 31, Issue 4, December 2026.ABSTRACT Background and Aims Data on cardiovascular autonomic neuropathy (CAN) are sparse in Charcot–Marie–Tooth disease. We aimed to determine the prevalence of CAN in CMT1A and CMTX1 and its associations with neuropathy severity and heart rate variability (HRV), compared with age‐ and sex‐matched controls. Methods Thirty‐six CMT1A, 24 CMTX1 patients,
Kryštof Prášil +4 more
wiley +1 more source
Frontiers in Molecular Neuroscience, 2018 Connexin channels play numerous essential roles in virtually every organ by mediating solute exchange between adjacent cells, or between cytoplasm and extracellular milieu.
Francesco Zonta +17 more
doaj +1 more source
Primary cultures of chick osteocytes retain functional gap junctions between osteocytes and between osteocytes and osteoblasts [PDF]
, 2008 The inaccessibility of osteocytes due to their embedment in the calcified bone matrix in vivo has precluded direct demonstration that osteocytes use gap junctions as a means of intercellular communication.
Sugawara, Yasuyo +6 more
core +1 more source
Oocyte–cumulus cell interaction: a key factor in early embryo development
Biological Reviews, Volume 101, Issue 5, Page 2265-2278, October 2026.ABSTRACT The evaluation of oocyte competence is a fundamental step in achieving successful outcomes following assisted reproduction techniques (ART). At present, however, conventional oocyte maturation assessment is carried out by morphological observation, which is a subjective method that does not consider molecular features.
Marc Torres‐Garrido +2 more
wiley +1 more source
A Chemical Chaperone Restores Connexin 26 Mutant Activity. [PDF]
ACS Pharmacol Transl Sci, 2023 Wang D +8 more
europepmc +1 more source
Connexin-Expression im Urothelkarzinom der menschlichen Harnblase [PDF]
, 2017 Connexin 43 stellt ein Eiweiß dar, welches in der Kommunikation der Zellen über Zellverbindungskanäle (Gap junctions), die die Kommunikation der Zellen untereinander regeln, wichtig für die Regulation der Vermehrung und der Spezialisierung von Zellen ...
Comberg, Detlev
core +1 more source
Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.Current Management & Limitations: Traditional auditory devices lack genetic curative potential and yield variable, non‐physiological hearing outcomes. OTOF gene therapy has shown promising clinical outcomes with dual‐AAV therapy. GJB2 gene therapy remains an emerging approach with significant translational challenges. Advances in vector design and cell‐
Jiahui Zhao, Mengzhao Xun, Yu Sun
wiley +1 more source
Connexin 26 (GJB2) Mutations Associated with Congenital Hearing Loss in a Country of Different Migration Routes: Turkey. [PDF]
Indian J Otolaryngol Head Neck Surg, 2023 Geden H, Seneldir L.
europepmc +1 more source