Results 131 to 140 of about 2,702,233 (230)

Supplementary Figure 1 from Connexin-26 Is a Key Factor Mediating Gemcitabine Bystander Effect

, 2011
Supplementary Figure 1 from Connexin-26 Is a Key Factor Mediating Gemcitabine Bystander ...
Laura Garcia-Rodríguez (15064645), Sandra Pérez-Torras (15064648), Cristina Fillat (200728), Anna Cascante (4832508), Adela Mazo (15064657), Meritxell Carrió (15064651), Ignacio García-Ribas (15064654)   +6 more
core   +1 more source

Celastrol‐Loaded Conductive Hydrogel Mitigates Myocardial Ischemia‐Reperfusion Injury and Restores Electrophysiological Function

Advanced Science, Volume 13, Issue 54, 28 September 2026.
Schematic illustration of the Pluronic F127 diacrylate/gelatin methacryloyl/poly(3,4‐ethylenedioxythiophene):poly(styrenesulfonate)/celastrol hydrogel (FGPC) for localized myocardial ischemia–reperfusion injury treatment. FGPC combines sustained celastrol delivery with PEDOT:PSS‐mediated conductive support to attenuate acute oxidative/inflammatory ...
Shixin Wang, Shaojie Chen, Chengzong Li, Hongyi Cheng, Jincheng Jiao, Xiafeng Peng, Yike Zhang, Wei Sun, Feng Zhang, Chang Cui, Minglong Chen   +10 more
wiley   +1 more source

Abnormal connexin expression in human chronic wounds

, 2015
Background Regulated alteration of connexin expression has been shown to be integral to acute wound repair. Downregulation of the gap-junction protein connexin 43 at the wound edge has been correlated with keratinocyte and fibroblast migration, while ...
Thrasivoulou, C, Serena, TE, Madden, L, Becker, DL, Phillips, Anthony, O'Neil, S, Richards, T, White, AM, Chin, KY, Sutcliffe, JE, Hu, R   +10 more
core   +1 more source

An Implantable Phototriggered Prodrug Depot Patch Enables Actively Programmable Drug Release for Post‐Myocardial Infarction Therapy

Advanced Science, Volume 13, Issue 51, 14 September 2026.
An implantable phototriggered prodrug depot patch (iPDP) is presented that enables actively programmable drug release post‐implantation. Covalently conjugated prodrug ensures minimal leakage; illumination parameters serve as a code to precisely control dose per release.
Haipeng Lu, Kaicheng Deng, Zhang Zhang, Qirui Wang, Weijing Gao, Liyin Shen, Lei Zhang, Wenting Hu, Yang Zhu, Zhengwei Mao, Tanchen Ren   +10 more
wiley   +1 more source

Molecular composition and distribution of gap junctions in the sensory epithelium of the human cochlea—a super-resolution structured illumination microscopy (SR-SIM) study

Upsala Journal of Medical Sciences, 2017
Background: Mutations in the GJB2 gene, which encodes the Connexin26 (Cx26) protein, are the most common cause of childhood hearing loss in American and European populations.
Wei Liu, Hao Li, Fredrik Edin, Johan Brännström, Rudolf Glueckert, Annelies Schrott-Fischer, Matyas Molnar, Dirk Pacholsky, Kristian Pfaller, Helge Rask-Andersen   +9 more
doaj   +1 more source

Molecular and Cellular Hallmarks of Age‐Related Vestibular Hair Cell Degeneration

Advanced Science, Volume 13, Issue 53, 24 September 2026.
This study utilizes single‐cell RNA‐seq transcriptomes, advanced imaging, and electrophysiology to examine universal and cell‐type‐specific aging signatures of vestibular hair cells. The study shows that impaired hair bundle function is a key driver of age‐related vestibular dysfunction.
Samadhi Kulasooriya, Huizhan Liu, Sarath Vijayakumar, Celia Bloom, Zhenhang Xu, Shu Tu, Benjamin J. Borgmeier, Mi Zhou, Litao Tao, Bechara Kachar, David Z. He   +10 more
wiley   +1 more source

A Novel Compound Heterozygous Mutation (35delg, 363delc) in the Connexin 26 Gene Causes Non-Syndromic Autosomal Recessive Hearing Loss

Acta Medica Iranica, 2014
Mutations in the Connexin 26 (Cx26) gene are a common cause of hereditary hearing loss in different populations. In the present study, an Iranian patient with bilateral hearing loss underwent molecular analysis for the causative mutation.
Habib Onsori, Mohammad Rahmati, Davood Fazli   +2 more
doaj  

Corrigendum: Virally mediated connexin 26 expression in postnatal scala media significantly and transiently preserves hearing in connexin 30 null mice. [PDF]

Front Cell Dev Biol, 2022
Zhang L, Wang W, Kim SM, Wang J, Zhou B, Kong W, Zheng J, Lin X.   +7 more
europepmc   +1 more source

Revising NHE‐1: From Cardiac Homeostasis to Heart Failure and Future Drug Development

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT NHE‐1 is a Na+/H+ exchanger that receives phosphorylation signals, binds calmodulin and responds to neurohormonal input from angiotensin II, endothelin‐1, and adrenergic pathways. In cardiac myocytes, NHE‐1 maintains pH homeostasis and couples to Na+/Ca2+ exchange and mitochondrial ion handling. During heart disease sustained activation drives
Vasileios Bouratzis, Nikoleta Douskou, Nikolaos P. Tzavellas, Yannis V. Simos, Petros Bozidis, Konstantinos I. Tsamis, Georgios S. Markopoulos, Dimitrios Peschos, Lampros Lakkas   +8 more
wiley   +1 more source

Organelle Crosstalk and Metabolic Reprogramming in Idiopathic Pulmonary Fibrosis: Mechanisms and Therapeutic Implications

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease of unknown cause, marked by excessive deposition of extracellular matrix (ECM) components such as collagen. This pathological accumulation results in progressive destruction of the lung architecture and ultimately leads to respiratory failure.
Yining Zhang, Ling Teng, Limin Gong, Yuandong Fu, Minyi Qian   +4 more
wiley   +1 more source