Temperature sensitivity of connexin 26 [PDF]
M Steffens +5 more
openaire +1 more source
Dorso‐Ventral and Night‐Day Regulation of Extracellular K+ Dynamics in Mouse Hippocampal Astrocytes
Hippocampal astrocytic K+ buffering varies by region and time. Ventral astrocytes show faster K+ accumulation due to reduced Kir4.1 function. Such regional divergence is modulated by circadian shifts in Kir4.1 and gap junction coupling. ABSTRACT Astrocytes regulate extracellular potassium (K+) through multiple mechanisms operating across distinct ...
Nariman Kiani +5 more
wiley +1 more source
Connexin 26 (GJB2) gene mutations linked with autosomal recessive non-syndromic sensor neural hearing loss in the Iraqi population. [PDF]
Al-Janabi AM, Ahmmed HS, Al-Khafaji SM.
europepmc +1 more source
Temperatursensitivität von Connexin 26 [PDF]
M Steffens +5 more
openaire +1 more source
Deletion of Astrocytic TNFR1 Attenuates Hyperexcitability and Initiation of Epileptogenesis
Inducible, astrocyte‐specific deletion of TNFR1 reduces basal EEG spectral power. Loss of astrocytic TNFR1 attenuates acute seizure activity in two distinct experimental models of epilepsy. Deletion of TNFR1 in astrocytes limits epilepsy development and hippocampal pathology in a mouse model of temporal lobe epilepsy with hippocampal sclerosis ...
Lukas Henning +6 more
wiley +1 more source
Connexin 43 and Connexin 26 Involvement in the Ponatinib-Induced Cardiomyopathy: Sex-Related Differences in a Murine Model. [PDF]
Madonna R +8 more
europepmc +1 more source
Relation between choice of partner and high frequency of connexin-26 deafness
Recessive mutations at the connexin-26 gene locus are now recognised as the cause of nearly half of all cases of genetic deafness in many populations. We suggest that this high frequency is only seen in populations with a long tradition of intermarriage ...
Nance, Walter E +2 more
core +1 more source
The Health Benefits of Exercise: Molecular and Cellular Mechanisms
Our synthesis integrates evidence on exercise‐induced regulatory mechanisms across multiple systems (musculoskeletal, cardiovascular, nervous, metabolic and immune), cross‐system, and aging. We also discusses adaptive regulation of exercise in extreme environments, along with the prospects and challenges of multiomics and AI‐driven precision exercise ...
Peifeng Ying +12 more
wiley +1 more source
Sensoryneural hearing loss with predominantly fall in 2000Hz secondary to connexin 26 gene mutation [PDF]
[ES] Las mutaciones en el gen de la conexina 26 dan lugar a hipoacusia neurosensorial prelocutiva de inicio en la infancia, habitualmente de carácter severo/profundo, aunque se han descrito hipoacusias leves o moderadas con algunas mutaciones.Se describe
Vergara Pastrana, Sandra P. +4 more
core
This study identifies Igκ expression in cardiomyocytes, with predominant localization at ICDs. Cardiomyocyte‐specific Igκ knockout induces cardiac dysfunction and ICDs structural disorganization. Mechanistically, Igκ stabilizes plectin to facilitate desmin‒actin network assembly and anchor desmin to DSP, which is critical for maintaining ICDs ...
Zhu Zhu +12 more
wiley +1 more source

