Connexins: synthesis, post-translational modifications, and trafficking in health and disease [PDF]
International Journal of Molecular Sciences, 2018 Connexins are tetraspan transmembrane proteins that form gap junctions and facilitate direct intercellular communication, a critical feature for the development, function, and homeostasis of tissues and organs.
Aasen, Trond +5 more
core +14 more sources
Connexins : substrates and regulators of autophagy [PDF]
BMC Cell Biology, 2016 Connexins mediate intercellular communication by assembling into hexameric channel complexes that act as hemichannels and gap junction channels. Most connexins are characterized by a very rapid turn-over in a variety of cell systems.
Bultynck, Geert +4 more
core +2 more sources
Epilepsia Open, EarlyView., 2022 Abstract The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force initiated the TASK3 working group to create common data elements (CDEs) for various aspects of preclinical epilepsy research studies, which could help improve the standardization of experimental designs.
Eleonora Aronica +6 more
wiley +1 more source
The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap junctional communication in astrocytes [PDF]
, 2014 In the brain, astrocytes represent the cellular population that expresses the highest amount of connexins (Cxs). This family of membrane proteins is the molecular constituent of gap junction channels and hemichannels that provide pathways for direct ...
Abudara, Verónica +8 more
core +11 more sources
Gap-junctional coupling between neutrophils and endothelial cells [PDF]
, 2003 Communication between leukocytes and endothelial cells is crucial for inflammatory reactions. Paracrine cross-talk and outside-in signaling (via adhesion molecules) have been characterized as communication pathways to date.
Gloe, Torsten +3 more
core +1 more source
An overview of the focus of the International Gap Junction Conference 2017 and Future Perspectives [PDF]
, 2018 n/
Kwak, Brenda R., Martin, Patricia E.
core +2 more sources
Nitric oxide enhances de novo formation of endothelial gap junctions [PDF]
, 2003 Objective: Gap junctions (formed by connexins, Cx) are important for functional coordination of cells in the vascular wall. However, little is known about their physiological regulation in this tissue.
Gloe, Torsten +3 more
core +1 more source
Molecular and functional characterization of gap junctions in the avian inner ear. [PDF]
, 2006 To analyze the fundamental role of gap junctions in the vertebrate inner ear, we examined molecular and functional characteristics of gap junctional communication (GJC) in the auditory and vestibular system of the chicken.
Becker, D, Forge, A, Nickel, R
core +1 more source
Dynamic changes in connexin expression correlate with key events in the wound healing process. [PDF]
, 2003 Wound healing is a complex process requiring communication for the precise co-ordination of different cell types. The role of extracellular communication through growth factors in the wound healing process has been extensively documented, but the role of
Becker, David L +4 more
core +1 more source
Connexin-mediated signaling in nonsensory cells is crucial for the development of sensory inner hair cells in the mouse cochlea [PDF]
, 2017 open9siMutations in the genes encoding for gap junction proteins connexin 26 (Cx26) and connexin 30 (Cx30) have been linked to syndromic and nonsyndromic hearing loss in mice and humans.
core +1 more source