Results 1 to 10 of about 11,092 (211)

Coordination of innate immune responses by connexins [PDF]

Frontiers in Immunology
Innate immunity comprises intricate cellular and tissue responses critical for host defense and tissue homeostasis. Intercellular communication is central to these responses and significantly influences infection, inflammatory disorders, and cancer ...
Qirou Wu, Qirou Wu, Tiejun Zhao, Pinglong Xu, Pinglong Xu   +4 more
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Connexins and Aging-Associated Respiratory Disorders: The Role in Intercellular Communications [PDF]

Biomedicines
This article reviews the contemporary understanding of the functional role of connexins in intercellular communications, their involvement in maintaining cellular and tissue homeostasis, and in aging-associated respiratory disease pathogenesis. Connexins
Tatiana Zubareva, Ekaterina Mironova, Anna Panfilova, Yulia Krylova, Gianluigi Mazzoccoli, Maria Greta Pia Marasco, Igor Kvetnoy, Peter Yablonsky   +7 more
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Connexin Expression Is Altered in the Eye Development of Yotari Mice: A Preliminary Study [PDF]

Biomolecules
This study aimed to explore how Dab1 functional silencing influences the expression patterns of different connexins in the developing yotari (yot) mice eyes as potential determinants of retinogenesis.
Ljubica Skelin, Anita Racetin, Nela Kelam, Marin Ogorevc, Ljubo Znaor, Mirna Saraga-Babić, Natalija Filipović, Yu Katsuyama, Zenon Pogorelić, Katarina Vukojević   +9 more
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Neural stem cell self-renewal stimulation by store-operated calcium entries in adult mouse area postrema: influence of leptin

Frontiers in Cellular Neuroscience, 2023
Neural stem cells (NSCs) persist in specific brain germinative niches and sustain neurogenesis throughout life in adult mammals. In addition to the two major stem cell niches in the subventricular zone and the hippocampal dentate gyrus, the area postrema
Cyrine Ben Dhaou, Elodie Terrié, Nadine Déliot, Thomas Harnois, Laetitia Cousin, Patricia Arnault, Bruno Constantin, Emmanuel Moyse, Valérie Coronas   +8 more
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Pattern Distribution of Connexins in the Ortho- and Parakeratinized Epithelium of the Lingual Mucosa in Birds

Cells, 2023
Connexins are important proteins involved in cell-to-cell communication and cytodifferentiation during renewal and cornification of the multilayered epithelia. So far, there is a lack of reports on this subject in birds’ structurally different ortho- and
Kinga Skieresz-Szewczyk, Hanna Jackowiak
doaj   +1 more source

Gap Junctions or Hemichannel-Dependent and Independent Roles of Connexins in Fibrosis, Epithelial–Mesenchymal Transitions, and Wound Healing

Biomolecules, 2023
Fibrosis initially appears as a normal response to damage, where activated fibroblasts produce large amounts of the extracellular matrix (ECM) during the wound healing process to assist in the repair of injured tissue. However, the excessive accumulation
Yuting Li, Francisca M. Acosta, Jean X. Jiang   +2 more
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Astroglial Connexins in Neurodegenerative Diseases

Frontiers in Molecular Neuroscience, 2021
Astrocytes play a crucial role in the maintenance of the normal functions of the Central Nervous System (CNS). During the pathogenesis of neurodegenerative diseases, astrocytes undergo morphological and functional remodeling, a process called reactive ...
Xiaomin Huang, Yixun Su, Nan Wang, Hui Li, Zhigang Li, Guowei Yin, Hui Chen, Jianqin Niu, Chenju Yi   +8 more
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The Multifaceted Role of Connexins in Tumor Microenvironment Initiation and Maintenance

Biology, 2023
Today’s research on the processes of carcinogenesis and the vital activity of tumor tissues implies more attention be paid to constituents of the tumor microenvironment and their interactions.
Olga M. Kutova, Anton D. Pospelov, Irina V. Balalaeva   +2 more
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Connexins in Cancer: Jekyll or Hyde?

Biomolecules, 2020
The expression, localization, and function of connexins, the protein subunits that comprise gap junctions, are often altered in cancer. In addition to cell–cell coupling through gap junction channels, connexins also form hemichannels that allow ...
Erin E. Mulkearns-Hubert, Ofer Reizes, Justin D. Lathia   +2 more
doaj   +1 more source

Atrial Fibrillation: Focus on Myocardial Connexins and Gap Junctions

Biology, 2022
Atrial fibrillation (AF) represents the most common type of clinical cardiac arrhythmia worldwide and contributes to substantial morbidity, mortality and socioeconomic burden. Aggregating evidence highlights the strong genetic basis of AF. In addition to
Yu-Han Guo, Yi-Qing Yang
doaj   +1 more source