Results 91 to 100 of about 42,495 (277)
Glia, EarlyView.Cell culture studies show disrupted astrocyte physiology in the leukodystrophy MLC. Are intact astrocytes similarly affected? This study on astrocytes in MLC mouse brain slices confirms and extends in vitro studies on altered astrocyte physiology. ABSTRACT Electrical signaling, driven by ion fluxes between intra‐ and extracellular compartments, is ...
Sven Kerst +5 more
wiley +1 more source
Gap junctions in the cardiovascular and immune systems
Brazilian Journal of Medical and Biological Research, 2000 Gap junctions are clusters of intercellular channels directly connecting the cytoplasm of adjacent cells. These channels are formed by proteins named connexins and are present in all metazoan organisms where they serve diverse functions ranging from ...
R. Rozental +2 more
doaj +1 more source
Connexins and Pannexins: New Insights into Microglial Functions and Dysfunctions
Frontiers in Molecular Neuroscience, 2016 Under physiological conditions, microglia adopt a resting phenotype associated with the production of anti-inflammatory and neurotrophic factors. In response to a wide variety of insults, these cells shift to an activated phenotype that is necessary for ...
Rosario Gajardo-Gómez +2 more
semanticscholar +1 more source
Studies of intercellular Ca2+ signaling and gap-junction coupling in the developing cochlea of mouse models affected by congenital hearing loss [PDF]
, 2013 Connexin 26 (Cx26) and connexin 30 (Cx30) form gap junction channels that allow the intercellular diffusion of the Ca2+ mobilizing second messenger IP3.
Rodriguez Hernandez, Laura
core +1 more source
Electrical coupling between ventricular myocytes and myofibroblasts in the infarcted mouse heart [PDF]
, 2017 Aims: Recent studies have demonstrated electrotonic coupling between scar tissue and the surrounding myocardium in cryoinjured hearts. However, the electrical dynamics occurring at the myocyte-nonmyocyte interface in the fibrotic heart remain ...
Conway, Simon J. +6 more
core +1 more source
Molecular Nutrition &Food Research, EarlyView.In this study we utilized proteomic profiling to investigate mechanisms linked to the cancer‐inhibitory effect of cranberry proanthocyanidins (CPACs) on reflux‐induced esophageal adenocarcinoma in a rat model. The results indicate that CPAC inhibits cancer through targeting multiple hallmarks of cancer known to be dysregulated in progression to ...
Yun Zhang +7 more
wiley +1 more source
Impact of Astroglial Connexins on Modafinil Pharmacological Properties.
Sleep, 2016 STUDY OBJECTIVES Modafinil is a non-amphetaminic wake-promoting compound used as therapy against sleepiness and narcolepsy. Its mode of action is complex, but modafinil has been recently proposed to act as a cellular-coupling enhancer in glial cells ...
A. Duchêne +14 more
semanticscholar +1 more source
Learning theories reveal loss of pancreatic electrical connectivity in diabetes as an adaptive response [PDF]
, 2013 Cells of almost all solid tissues are connected with gap junctions which permit the direct transfer of ions and small molecules, integral to regulating coordinated function in the tissue.
Goel, Pranay, Mehta, Anita
core +3 more sources
Neuroprotection, EarlyView.Cerebral ischemia is a serious neurological disease that mainly leads to pathological changes such as mitochondrial dysfunction, oxidative stress and iron death. Mitochondria play a key role in the regulation of cellular energy metabolism and oxidative stress, and their damage can lead to mitochondrial damage, reduced adenosine triphosphate production,
Shuchen Meng +9 more
wiley +1 more source
Pannexin 1 Is Critically Involved in Feedback from Horizontal Cells to Cones
Frontiers in Molecular Neuroscience, 2017 Retinal horizontal cells (HCs) feed back negatively to cone photoreceptors and in that way generate the center/surround organization of bipolar cell receptive fields. The mechanism by which HCs inhibit photoreceptors is a matter of debate.
Valentina Cenedese +6 more
doaj +1 more source