Results 21 to 30 of about 42,495 (277)
Connexins and Aging-Associated Respiratory Disorders: The Role in Intercellular Communications. [PDF]
BiomedicinesThis article reviews the contemporary understanding of the functional role of connexins in intercellular communications, their involvement in maintaining cellular and tissue homeostasis, and in aging-associated respiratory disease pathogenesis. Connexins
Zubareva T +7 more
europepmc +2 more sources
GJA1-20k, a Short Isoform of Connexin43, from Its Discovery to Its Potential Implication in Cancer Progression. [PDF]
CellsThe Connexin43 transmembrane protein (Cx43), encoded by the GJA1 gene, is a member of a multigenic family of proteins that oligomerize to form hemichannels and intercellular channels, allowing gap junctional intercellular communication between adjacent ...
Fournier S +3 more
europepmc +2 more sources
Frontiers in Cellular Neuroscience, 2023 Neural stem cells (NSCs) persist in specific brain germinative niches and sustain neurogenesis throughout life in adult mammals. In addition to the two major stem cell niches in the subventricular zone and the hippocampal dentate gyrus, the area postrema
Cyrine Ben Dhaou +8 more
doaj +1 more source
Connexins in the Heart: Regulation, Function and Involvement in Cardiac Disease
International Journal of Molecular Sciences, 2021 Connexins are a family of transmembrane proteins that play a key role in cardiac physiology. Gap junctional channels put into contact the cytoplasms of connected cardiomyocytes, allowing the existence of electrical coupling.
A. Rodríguez-Sinovas +4 more
semanticscholar +1 more source
Cells, 2023 Connexins are important proteins involved in cell-to-cell communication and cytodifferentiation during renewal and cornification of the multilayered epithelia. So far, there is a lack of reports on this subject in birds’ structurally different ortho- and
Kinga Skieresz-Szewczyk, Hanna Jackowiak
doaj +1 more source
Biomolecules, 2023 Fibrosis initially appears as a normal response to damage, where activated fibroblasts produce large amounts of the extracellular matrix (ECM) during the wound healing process to assist in the repair of injured tissue. However, the excessive accumulation
Yuting Li +2 more
doaj +1 more source
Glial connexins and pannexins in the healthy and diseased brain.
Physiological Reviews, 2020 Over the past several decades a large amount of data have established that glial cells, the main cell population in the brain, dynamically interact with neurons and thus impact their activity and survival.
C. Giaume +3 more
semanticscholar +1 more source
Connexins in epidermal health and diseases: insights into their mutations, implications, and therapeutic solutions. [PDF]
Front PhysiolThe epidermis, the outermost layer of the skin, serves as a protective barrier against external factors. Epidermal differentiation, a tightly regulated process essential for epidermal homeostasis, epidermal barrier formation and skin integrity ...
Yasarbas SS +5 more
europepmc +2 more sources
FROM PHYSIOLOGICAL TO NEOPLASTIC TRANSFORMATION: THE CRITICAL ROLES OF CONNEXINS AND WT1 [PDF]
Euromediterranean Biomedical Journal, 2022 Glioblastoma and soft tissue sarcomas are tumors characterized by poor prognosis, low overall survival and critical hallmarks that allow such tumors to evade homeostatic controlling mechanisms.
Giovanni Li Volti
doaj +1 more source
Connexins in cancer: bridging the gap to the clinic
Oncogene, 2019 Gap junctions comprise arrays of intercellular channels formed by connexin proteins and provide for the direct communication between adjacent cells. This type of intercellular communication permits the coordination of cellular activities and plays key ...
T. Aasen +7 more
semanticscholar +1 more source