Results 31 to 40 of about 42,495 (277)
Connexins—Therapeutic Targets in Cancers
International Journal of Molecular Sciences, 2020 Connexins (Cx) are members of a protein family that forms intercellular channels localised in gap junction (GJ) plaques and single transmembrane channels called hemichannels.
Magdalena Nalewajska +4 more
semanticscholar +1 more source
Antioxidants, 2021 The lens is continuously exposed to oxidative stress insults, such as ultraviolet radiation and other oxidative factors, during the aging process. The lens possesses powerful oxidative stress defense systems to maintain its redox homeostasis, one of ...
Yumeng Quan +4 more
doaj +1 more source
Connexin Hemichannels in Astrocytes: Role in CNS Disorders
Frontiers in Molecular Neuroscience, 2019 In the central nervous system (CNS), astrocytes form networks interconnected by gap junctions made from connexins of the subtypes Cx30 and Cx43. When unopposed by an adjoining hemichannel, astrocytic connexins can act as hemichannels to control the ...
LingYan Xing +4 more
doaj +1 more source
Electrical synaptic transmission requires a postsynaptic scaffolding protein
eLife, 2021 Electrical synaptic transmission relies on neuronal gap junctions containing channels constructed by Connexins. While at chemical synapses neurotransmitter-gated ion channels are critically supported by scaffolding proteins, it is unknown if channels at ...
Abagael M Lasseigne +9 more
doaj +1 more source
Gap junction protein connexin43 exacerbates lung vascular permeability. [PDF]
PLoS ONE, 2014 Increased vascular permeability causes pulmonary edema that impairs arterial oxygenation and thus contributes to morbidity and mortality associated with Acute Respiratory Distress Syndrome and sepsis.
James J O'Donnell +3 more
doaj +1 more source
A Human-Derived Monoclonal Antibody Targeting Extracellular Connexin Domain Selectively Modulates Hemichannel Function [PDF]
, 2019 Connexin hemichannels, which are plasma membrane hexameric channels (connexons) composed of connexin protein protomers, have been implicated in a host of physiological processes and pathological conditions. A number of single point pathological mutations
Buratto, Damiano +12 more
core +1 more source
Connexin’s Connection in Breast Cancer Growth and Progression
International Journal of Cell Biology, 2016 Gap junctions are cell-to-cell junctions that are located in the basolateral surface of two adjoining cells. A gap junction channel is composed of a family of proteins called connexins.
Debarshi Banerjee
doaj +1 more source
Connexins and Integrins in Exosomes
Cancers, 2019 Connexins and integrins, the two structurally and functionally distinct families of transmembrane proteins, have been shown to be inter-connected by various modes of cross-talk in cells, such as direct physical coupling via lateral contact, indirect ...
M. Shimaoka +4 more
semanticscholar +1 more source
Cardiology Research and Practice, 2012 Cell-to-cell interactions via gap junctional communication and connexon hemichannels are involved in the pathogenesis of diabetes. Gap junctions are highly specialized transmembrane structures that are formed by connexon hemichannels, which are further ...
Josephine A. Wright +2 more
doaj +1 more source
Molecular basis of gap junctional communication in the CNS of the leech Hirudo medicinalis [PDF]
, 2004 Gap junctions are intercellular channels that allow the passage of ions and small molecules between cells. In the nervous system, gap junctions mediate electrical coupling between neurons.
Bacon, Jonathan P +3 more
core +2 more sources