Expression of connexins in human preimplantation embryos in vitro [PDF]
, 2004 Intercellular communication via gap junctions is required to coordinate developmental processes in the mammalian embryo. We have investigated if the connexin (Cx) isoforms known to form gap junctions in rodent preimplantation embryos are also expressed ...
Bloor, D.J. +6 more
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Reduced expression of multiple gap junction proteins is a feature of cervical dysplasia
Molecular Cancer, 2005 Cervical dysplasia is a premalignant lesion associated with human papillomavirus (HPV) infection which, over time, can turn cancerous. Previous studies have indicated that loss of gap junctions may be a feature of cervical cancer and premalignant ...
Edward Mike +3 more
doaj +1 more source
Connexin: a potential novel target for protecting the central nervous system?
Neural Regeneration Research, 2015 Connexin subunits are proteins that form gap junction channels, and play an important role in communication between adjacent cells. This review article discusses the function of connexins/hemichannels/gap junctions under physiological conditions, and ...
Hong-yan Xie +3 more
doaj +1 more source
Diet-dependent immunohistochemical evaluation of connexin 43 in the sheep rumen [PDF]
, 2016 The objective of this study was to characterize the immunohistochemical localization of plasma membrane connexin 43 in the rumen of sheep after changing the diet from hay (ad libitum) to a mixed hay/concentrate diet.
Ahmed, Rasha S. +2 more
core +1 more source
Connexins and Pannexins: Important Players in Tumorigenesis, Metastasis and Potential Therapeutics
International Journal of Molecular Sciences, 2018 Since their characterization more than five decades ago, gap junctions and their structural proteins—the connexins—have been associated with cancer cell growth.
S. Graham, Jean X. Jiang, M. Mesnil
semanticscholar +1 more source
Inhibition of gap junction and adherens junction assembly by connexin and A-CAM antibodies [PDF]
, 1992 We examined the roles of the extracellular domains of a gap junction protein and a cell adhesion molecule in gap junction and adherens junction formation by altering cell interactions with antibody Fab fragments.
Johnson, Ross G. +3 more
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Astroglial connexins and cognition: memory formation or deterioration?
Bioscience Reports, 2019 Connexins are the membrane proteins that form high-conductance plasma membrane channels and are the important constituents of gap junctions and hemichannels.
Jinting He +3 more
semanticscholar +1 more source
Cx43 channels and signaling via IP3/Ca2+, ATP, and ROS/NO propagate radiation-induced DNA damage to non-irradiated brain microvascular endothelial cells [PDF]
, 2020 Radiotherapeutic treatment consists of targeted application of radiation beams to a tumor but exposure of surrounding healthy tissue is inevitable.
Bultynck, Geert +10 more
core +1 more source
Regulation of gap junctions by protein phosphorylation
Brazilian Journal of Medical and Biological Research, 1998 Gap junctions are constituted by intercellular channels and provide a pathway for transfer of ions and small molecules between adjacent cells of most tissues.
J.C. Sáez +3 more
doaj +1 more source
Connexin 30 deletion exacerbates cochlear senescence and age-related hearing loss
Frontiers in Cell and Developmental Biology, 2022 Pathogenic mutations in the Gjb2 and Gjb6 genes, encoding connexin 26 (Cx26) and connexin 30 (Cx30), respectively, have been linked to the most frequent monogenic hearing impairment, nonsyndromic hearing loss, and deafness DFNB1.
Fabiola Paciello +10 more
doaj +1 more source