Diet-dependent immunohistochemical evaluation of connexin 43 in the sheep rumen [PDF]
The objective of this study was to characterize the immunohistochemical localization of plasma membrane connexin 43 in the rumen of sheep after changing the diet from hay (ad libitum) to a mixed hay/concentrate diet.
Ahmed, Rasha S. +2 more
core +1 more source
Wearable Sensors Fabricated by 3D‐Printed Composite Hydrogel with 2D Fillers
This review explores how 3D printing integrates 2D conductive fillers into hydrogel matrices to fabricate high‐performance flexible sensors. By tailoring microstructures and nanomaterial interactions, these devices achieve enhanced sensitivity, durability, and environmental adaptability for healthcare monitoring, human‐machine interfaces, and robotic ...
Yaxuan Li +5 more
wiley +1 more source
Advances in the genetics of refractive errors: Contributions from the CREAM consortium
Abstract The Consortium for Refractive Error and Myopia (CREAM) was established in 2011, bringing together an international team of researchers studying more than 30 cohorts. Since its establishment, CREAM has played a pivotal role in research investigating the genetics of myopia and other refractive errors, serving as a key driver of progress in the ...
Sze Wai Rosa Li +11 more
wiley +1 more source
Application Strategies of Bone Marrow Mesenchymal Stromal Cells in Bone‐Related Diseases
Engineered BMSCs and vesicles enhance therapy effects for bone diseases via multi‐strategic approaches. ABSTRACT Bone‐related diseases (e.g., osteoporosis, osteoarthritis and fractures) exhibit a rising global incidence, imposing significant burdens on both quality of life and healthcare systems.
Xuemei Long +6 more
wiley +1 more source
Expression of connexins in human preimplantation embryos in vitro [PDF]
Intercellular communication via gap junctions is required to coordinate developmental processes in the mammalian embryo. We have investigated if the connexin (Cx) isoforms known to form gap junctions in rodent preimplantation embryos are also expressed ...
Bloor, D.J. +6 more
core +4 more sources
Acidosis potentiates endothelium-dependent vasorelaxation and gap junction communication in the superior mesenteric artery. [PDF]
Extracellular pH is an important physiological determinant of vascular tone that is normally maintained within 7.35-7.45. Any change outside this range leads to severe pathological repercussions.
Mohanty, Ipsita +3 more
core +2 more sources
Artificial lipidation of proteins and peptides: from mechanism to clinical applications
Artificial lipidation transforms protein and peptide therapeutics by attaching fatty acid chains through reversible or permanent chemical strategies. This biomimetic approach delivers four key therapeutic advantages: extended circulation times (enabling weekly instead of daily dosing), alternative administration routes including oral delivery, precise ...
Jiaming Mu, Emily Vong, Sheiliza Carmali
wiley +1 more source
Connexin-dependent neuroglial networking as a new therapeutic target [PDF]
Astrocytes and neurons dynamically interact during physiological processes, and it is now widely accepted that they are both organized in plastic and tightly regulated networks.
Christian C. Naus +5 more
core +2 more sources
In cardiac electrophysiology, gap junctions are often conceptualized as passive resistors that allow for electrical charge to move between cells. From that standpoint, gap junctions seem like rigid structures that sit idle between cells as small ions traverse across.
openaire +1 more source
EHD4 and ASAP2 are critical negative regulators of the claudin‐5‐based endothelial barrier
Cell‐surface CLDN‐5 protein levels can be evaluated using a probe that can bind to the extracellular domains of CLDN‐5. A probe derived from Clostridium perfringens enterotoxin allows us to isolate cells with high CLDN‐5 protein levels from a knockout cell library.
Yosuke Hashimoto +8 more
wiley +1 more source

