Results 61 to 70 of about 42,495 (277)

Mouse Panx1 Is Dispensable for Hearing Acquisition and Auditory Function [PDF]

, 2017
Panx1 forms plasma membrane channels in brain and several other organs, including the inner ear. Biophysical properties, activation mechanisms and modulators of Panx1 channels have been characterized in detail, however the impact of Panx1 on auditory ...
Carrer, Andrea, Chiani, Francesco, Ciubotaru, Catalin D., Crispino, Giulia, Fetoni, Anna R., M. Salvatore, Anna, Mammano, Fabio, Mazzarda, Flavia, Monyer, Hannah, Nardin, Chiara, Paciello, Fabiola, Pasquini, Miriam, Peres, Chiara, Raspa, Marcello, Scavizzi, Ferdinando, Ziraldo, Gaia, Zorzi, Veronica   +16 more
core   +4 more sources

Progress and Application of Multifunctional Hydrogel in Radioactive Skin Injury

Advanced Materials Interfaces, EarlyView.
This review examines healing challenges in radiation‐wound injuries, where ionizing radiation impairs immune and tissue repair processes. Hydrogels, with their biocompatibility, antimicrobial properties, and drug delivery capabilities, present a transformative solution. It compares hydrogel efficacy in radiation‐induced versus common wounds, highlights
Xinyue Cui, Jingyi Wang, Xinyi Xu, Xiqian Cao, Yingtang Zhou, Jiaming Guo   +5 more
wiley   +1 more source

Acidosis potentiates endothelium-dependent vasorelaxation and gap junction communication in the superior mesenteric artery. [PDF]

, 2018
Extracellular pH is an important physiological determinant of vascular tone that is normally maintained within 7.35-7.45. Any change outside this range leads to severe pathological repercussions.
Mohanty, Ipsita, Parija, Subas Chandra, Rattan, Satish, Suklabaidya, Sujit   +3 more
core   +2 more sources

Advances in Microfluidic Cochlea‐On‐A‐Chip

Advanced Science, EarlyView.
This review systematically examines diverse cell sources for inner ear organoids and outlines stepwise induction protocols. Furthermore, it discusses current applications and prospective developments of cochlea‐on‐a‐chip technologies in areas such as deafness modeling, mechanistic studies, and drug evaluation, with particular focus on gene‐therapy drug
Tian Shen, Shanying Han, Weiwei He, Wen Yang, Xinghua Tang, Xiaolong Zhao, Xinghong Liu, Zhenhua Shao, Lin Cheng, Yu Zhao, Jiangang Fan   +10 more
wiley   +1 more source

Connexins and Nitric Oxide Inside and Outside Mitochondria: Significance for Cardiac Protection and Adaptation

Frontiers in Physiology, 2018
Irreversible myocardial damage happens in the presence of prolonged and severe ischemia. Several phenomena protect the heart against myocardial infarction and other adverse outcomes of ischemia and reperfusion (IR), namely: hibernation related to stunned
Maria Shvedova, Yana Anfinogenova, Yana Anfinogenova, Sergey V. Popov, Dmitriy N. Atochin, Dmitriy N. Atochin   +5 more
doaj   +1 more source

Endothelium-Derived Hyperpolarizing Factor and Myoendothelial Coupling: The in vivo Perspective

Frontiers in Physiology, 2020
The endothelium controls vascular tone adopting blood flow to tissue needs. It releases chemical mediators [e.g., nitric oxide (NO), prostaglandins (PG)] and exerts appreciable dilation through smooth muscle hyperpolarization, thus termed endothelium ...
Kjestine Schmidt, Kjestine Schmidt, Cor de Wit, Cor de Wit   +3 more
doaj   +1 more source

Cues to opening mechanisms from in silico electric field excitation of cx26 hemichannel and in vitro mutagenesis studies in HeLa transfectans [PDF]

, 2018
Connexin channels play numerous essential roles in virtually every organ by mediating solute exchange between adjacent cells, or between cytoplasm and extracellular milieu.
Bruno, Francesca, Buratto, Damiano, Carrer, Andrea, Crispino, Giulia, Mammano, Fabio, Pantano, Sergio, Yang, Guang, Zonta, Francesco   +7 more
core   +1 more source

Viral‐Mediated Connexin 26 Expression Combined with Dexamethasone Rescues Hearing in a Conditional Gjb2 Null Mice Model

Advanced Science, EarlyView.
AAV2.7m8 serotype combined with the gfaABC1D promoter targets infection of supporting cells (SCs). AAV2.7m8‐gfaABC1D‐Gjb2 administration to mice results in excessive immune responses. The combination of AAV2.7m8‐gfaABC1D‐Gjb2 with dexamethasone (DEX) shows a synergistic effect and enhances the gene therapy effect in a conditional Cx26 null mice model ...
Xiaohui Wang, Li Zhang, Sen Chen, Le Xie, Yue Qiu, Chenyang Kong, Ge Yin, Weijia Kong, Yu Sun   +8 more
wiley   +1 more source

A structural and functional comparison of gap junction channels composed of connexins and innexins

Developmental Neurobiology, 2016
Methods such as electron microscopy and electrophysiology led to the understanding that gap junctions were dense arrays of channels connecting the intracellular environments within almost all animal tissues.
I. M. Skerrett, Jamal B. Williams
semanticscholar   +1 more source

What's the Function of Connexin 32 in the Peripheral Nervous System? [PDF]

, 2018
Connexin 32 (Cx32) is a fundamental protein in the peripheral nervous system (PNS) as its mutations cause the X-linked form of Charcot-Marie-Tooth disease (CMT1X), the second most common form of hereditary motor and sensory neuropathy and a demyelinating
Bortolozzi, Mario
core   +1 more source