Results 81 to 90 of about 42,495 (277)
Connexins: a myriad of functions extending beyond assembly of gap junction channels
Cell Communication and Signaling, 2009 Connexins constitute a large family of trans-membrane proteins that allow intercellular communication and the transfer of ions and small signaling molecules between cells.
Mroue Rana M +3 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2020 In vitro transdifferentiation of patient-derived mesenchymal stem/stromal cells (MSCs) into neurons is of special interest for treatment of neurodegenerative diseases.
Nadine Dilger +8 more
doaj +1 more source
Gap junction connexins in female reproductive organs: implications for women's reproductive health.
Human Reproduction Update, 2015 BACKGROUND Connexins comprise a family of ~20 proteins that form intercellular membrane channels (gap junction channels) providing a direct route for metabolites and signalling molecules to pass between cells.
E. Winterhager, G. Kidder
semanticscholar +1 more source
The Anatomical Record, EarlyView.Abstract Autonomic nerves are crucial in cardiac function and pathology. However, data on the distribution of cholinergic and noradrenergic nerves in normal and pathologic human hearts is lacking. Nonfailing donor hearts were pressure‐perfusion fixed, imaged, and dissected. Left ventricular cardiomyopathy samples were also obtained.
Peter Hanna +15 more
wiley +1 more source
Insulin and Metformin are Associated With Reduced Risk of Amyotrophic Lateral Sclerosis
Chronic Diseases and Translational Medicine, EarlyView.Human insulin heterodimer (A). Human insulin heterodimer (dark blue) docked within center of Cx43 channel (B) Abstract Background Type 2 diabetes (T2D), but not type 1, protected against amyotrophic lateral sclerosis (ALS). In T2D serum insulin is normal or elevated in the early stages.
Steven Lehrer, Peter H. Rheinstein
wiley +1 more source
Synchronization in Electrically Coupled Neural Networks [PDF]
arXiv, 2006 In this report, we investigate the synchronization of temporal activity in an electrically coupled neural network model. The electrical coupling is established by homotypic static gap-junctions (Connexin 43). Two distinct network topologies, namely: {\em sparse random network, (SRN)} and {\em fully connected network, (FCN)} are used to establish the ...
arxiv
BMC Cell Biology, 2017 This review comes after the International Gap Junction Conference (IGJC 2015) and describes the current knowledge on the function of the specific motifs of connexins in the regulation of the formation of gap junction channels.
T. Desplantez
semanticscholar +1 more source
Role of Connexin-Based Gap Junction Channels in Communication of Myelin Sheath in Schwann Cells
Frontiers in Cellular Neuroscience, 2019 Peripheral nerves have the capacity to conduct action potentials along great distances and quickly recover following damage which is mainly due to Schwann cells (SCs), the most abundant glial cells of the peripheral nervous system (PNS).
Bruno A. Cisterna +3 more
doaj +1 more source
Connections with connexins: the molecular basis of direct intercellular signaling.
European Journal of Biochemistry, 1996 Adjacent cells share ions, second messengers and small metabolites through intercellular channels which are present in gap junctions. This type of intercellular communication permits coordinated cellular activity, a critical feature for organ homeostasis
R. Bruzzone, T. W. White, D. Paul
semanticscholar +1 more source
Adjuvant therapeutic potential of tonabersat in the standard treatment of glioblastoma : a preclinical F98 glioblastoma rat model study [PDF]
, 2019 Purpose Even with an optimal treatment protocol, the median survival of glioblastoma (GB) patients is only 12-15 months. Hence, there is need for novel effective therapies that improve survival outcomes.
Bonte, Ellen +11 more
core +1 more source