Results 131 to 140 of about 849 (177)

Multi-omics characterization of toxin expression and producing organs in the predatory gastropods Monoplex corrugatus and Stramonita haemastoma. [PDF]

BMC Genomics
Ringeval A, Modica MV, Kantor Y, Tenorio MJ, Galindo JCG, Puillandre N, Farhat S.   +6 more
europepmc   +1 more source

Nicotinic acetylcholine receptors in pain modulation. [PDF]

Front Pharmacol
Cheng J, Chang J, Li S.
europepmc   +1 more source

Proteo-Transcriptomic Analysis of the Venom Gland of the Cone Snail <i>Cylinder canonicus</i> Reveals the Origin of the Predatory-Evoked Venom. [PDF]

Toxins (Basel)
Ratibou Z, Ebou AET, Bich C, Saintmont F, Valette G, Cazals G, Koua DK, Inguimbert N, Dutertre S.   +8 more
europepmc   +1 more source

χ-Conotoxins are an Evolutionary Innovation of Mollusk-Hunting Cone Snails as a Counter-Adaptation to Prey Defense. [PDF]

Mol Biol Evol
Espino S, Watkins M, Probst R, Koch TL, Chase K, Imperial J, Robinson SD, Flórez Salcedo P, Taylor D, Gajewiak J, Yandell M, Safavi-Hemami H, Olivera BM.   +12 more
europepmc   +1 more source

Molecular Phylogeny, Classification and Evolution of Conopeptides [PDF]

Journal of Molecular Evolution, 2012
Conopeptides are toxins expressed in the venom duct of cone snails (Conoidea, Conus). These are mostly well-structured peptides and mini-proteins with high potency and selectivity for a broad range of cellular targets.
Baldomero Olivera, N Puillandre
exaly   +7 more sources

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Therapeutic Potential of Conopeptides

Future Medicinal Chemistry, 2012
Conopeptides from the venoms of marine snails have attracted much interest as leads in drug design. Currently, one drug, Prialt(®), is on the market as a treatment for chronic neuropathic pain. Conopeptides target a range of ion channels, receptors and transporters, and are typically small, relatively stable peptides that are generally amenable to ...
Christina I. Schroeder, David Craik
exaly   +6 more sources

Structure, function and therapeutic potential of omega conopeptides: Novel blockers of neuronal calcium channels

Journal of Chemical Sciences, 1994
Recent molecular cloning strategies have revealed that the diversity of voltage-sensitive calcium channels (VSCC) in the nervous system is much larger than indicated by electrophysiological studies.
Ramachandran, J.
exaly   +2 more sources

Stereochemistry of 4-hydroxyproline affects the conformation of conopeptides†

Chemical Communications, 2010
The cis/trans isomerization of 4-hydroxyproline is shown to remarkably affect the conformation of conopeptides with or without disulfide bonds.
Jia Xu, Weihong Du, Baohuai Wang
exaly   +3 more sources

Novel conopeptides in a form of disulfide-crosslinked dimer

Peptides, 2010
In our present work, seven conotoxins and conopeptides were cloned from four cone snail species based on the M-superfamily signal peptides. Among them, two conopeptides, Vt3.1 and Vt3.2, showed unusual sequence characteristics. Both of them contained two cysteines that are separated by just one non-cysteine residue. In vitro, the chemically synthesized
Zhan-Yun Guo, Can Peng, Cheng-Wu Chi
exaly   +3 more sources

Conopeptides: From deadly venoms to novel therapeutics

Drug Discovery Today, 2000
Marine cone snails have developed many distinct venoms that contain biologically active peptides as part of an envenomation survival strategy for feeding and defense. These peptides, known as conopeptides, have been optimized through evolution to target specific ion channels and receptors with very high affinities and selectivities.
R Tyler McCabe
exaly   +3 more sources