Results 141 to 150 of about 849 (177)
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Conopeptide characterization and classifications: An analysis using ConoServer
Toxicon, 2010Cone snails are carnivorous marine gastropods that have evolved potent venoms to capture their prey. These venoms comprise a rich and diverse cocktail of peptide toxins, or conopeptides, whose high diversity has arisen from an efficient hypermutation mechanism, combined with a high frequency of post-translational modifications.
Kaas, Quentin +2 more
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Drugs from the Sea: Conopeptides as Potential Therapeutics
Current Medicinal Chemistry, 2004Marine cone snails from the genus Conus are estimated to consist of up to 700 species. These predatory molluscs have devised an efficient venom apparatus that allows them to successfully capture polychaete worms, other molluscs or in some cases fish as their primary food sources.
Bruce G, Livett +2 more
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Cardiovascular Effects of ω-Conopeptides in Conscious Rats: Mechanisms of Action
Journal of Cardiovascular Pharmacology, 1992We examined the effects of omega-conopeptides, a novel class of neuronal voltage-gated calcium channel antagonists, on hemodynamic responses in rats. Intravenous (i.v.) injections of SNX-111 (omega-conopeptide MVIIA) dose-dependently decreased arterial blood pressure (BP) in conscious rats. Intracerebroventricular (i.c.v.) SNX-111 injections (580 pmol)
S. Scott Bowersox +5 more
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Towards an integrated venomics approach for accelerated conopeptide discovery
Toxicon, 2012Conopeptides and conotoxins are small peptides produced by cone snails as a part of their predatory/defense strategies that target key ion channels and receptors in the nervous system. Some of these peptides also potently target mammalian ion channels involved in pain pathways.
Jutty Rajan, Prashanth +2 more
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Drugs from Slugs. Part II – Conopeptide bioengineering
Chemico-Biological Interactions, 2012The biological transformation of toxins as research probes, or as pharmaceutical drug leads, is an onerous and drawn out process. Issues regarding changes to pharmacological specificity, desired potency, and bioavailability are compounded naturally by their inherent toxicity.
Jon-Paul, Bingham +3 more
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Discovery and development of the χ-conopeptide class of analgesic peptides
Toxicon, 2012Cone snail venoms continue to provide a rich source of bioactive peptides useful as research tools and leads to new therapeutics. We isolated two closely related conopeptides, MrIA and MrIB, which defined the χ-conopeptide class of bioactive peptides based on their unique ability to highly selectively and non-competitively inhibit the norepinephrine ...
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DISCOVERY AND CHARACTERISATION OF CONOPEPTIDE ANTAGONISTS OF NICOTINIC ACETYLCHOLINE RECEPTORS
2023Neuronal nicotinic acetylcholine receptors (nAChRs) are of crucial physiological importance and they have also been implicated in a number of pathological conditions thus representing important targets for pharmacological intervention. Knowledge of the structure-function relationships of receptor: ligand interactions can facilitate design of improved ...
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Structure-aided function assignment to the transcriptomic conopeptide Am931
ToxiconImplementation of the next-generation technologies for gene sequencing of venom duct transcriptome has provided a large number of peptide sequences of marine cone snails. Emerging technologies on computational platforms are now rapidly evolving for the accurate predictions of the 3D structure of the polypeptide using the primary sequence.
Shamasoddin, Shekh +9 more
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Synthesis and insecticidal activity of cysteine-free conopeptides from
Toxicon, 2023Jiao Chen, Bingmiao Gao
exaly