Results 161 to 170 of about 1,314 (186)
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Towards an integrated venomics approach for accelerated conopeptide discovery
Toxicon, 2012Conopeptides and conotoxins are small peptides produced by cone snails as a part of their predatory/defense strategies that target key ion channels and receptors in the nervous system. Some of these peptides also potently target mammalian ion channels involved in pain pathways.
Jutty Rajan, Prashanth +2 more
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Drugs from Slugs. Part II – Conopeptide bioengineering
Chemico-Biological Interactions, 2012The biological transformation of toxins as research probes, or as pharmaceutical drug leads, is an onerous and drawn out process. Issues regarding changes to pharmacological specificity, desired potency, and bioavailability are compounded naturally by their inherent toxicity.
Jon-Paul, Bingham +3 more
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Post-translationally modified conopeptides: Biological activities and pharmacological applications
Peptides, 2021Conus venoms comprise a large variety of biologically active peptides (conopeptides or conotoxins) that are employed for prey capture and other biological functions. Throughout the course of evolution of the cone snails, they have developed an envenomation scheme that necessitates a potent mixture of peptides, most of which are highly post ...
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Conotoxins and other conopeptides
2014Conopeptides are a large family of peptide toxins produced by marine cone snails. They act with high potency and exquisite specificity on a range of ion channels and transporters of the nervous system, making them valuable drug leads and important molecular probes in neurophysiological studies.
Kaas, Quentin, Craik, David J.
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Discovery and development of the χ-conopeptide class of analgesic peptides
Toxicon, 2012Cone snail venoms continue to provide a rich source of bioactive peptides useful as research tools and leads to new therapeutics. We isolated two closely related conopeptides, MrIA and MrIB, which defined the χ-conopeptide class of bioactive peptides based on their unique ability to highly selectively and non-competitively inhibit the norepinephrine ...
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DISCOVERY AND CHARACTERISATION OF CONOPEPTIDE ANTAGONISTS OF NICOTINIC ACETYLCHOLINE RECEPTORS
2023Neuronal nicotinic acetylcholine receptors (nAChRs) are of crucial physiological importance and they have also been implicated in a number of pathological conditions thus representing important targets for pharmacological intervention. Knowledge of the structure-function relationships of receptor: ligand interactions can facilitate design of improved ...
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Pharmacology of three classes of conopeptides that disrupt sympathetic neurotransmission [PDF]
, 2023 Marine snails of the genus Conus ("cone snails") use a particularly sophisticated strategy to capture their prey. They inject a venom containing a cocktail of bioactive peptides, which causes rapid immobilization by disrupting neurotransmission. The number of different peptides in the venom of a single species of cone snail may exceed 100.
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Structure-aided function assignment to the transcriptomic conopeptide Am931
ToxiconImplementation of the next-generation technologies for gene sequencing of venom duct transcriptome has provided a large number of peptide sequences of marine cone snails. Emerging technologies on computational platforms are now rapidly evolving for the accurate predictions of the 3D structure of the polypeptide using the primary sequence.
Shamasoddin, Shekh +9 more
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Conopeptides from Conus striatus and Conus textile by cDNA cloning☆
Peptides, 1999Conopeptide content in Conus textile and Conus striatus venoms were examined by polymerase chain reaction amplification of alpha-conopeptide cDNA and rapid amplification of 3' cDNA ends of O-superfamily conopeptide cDNA. Two new alpha-conopeptide sequences and six new O-superfamily conopeptide sequences from C.
B S, Lu +4 more
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