Results 151 to 160 of about 1,314 (186)

Molecular Phylogeny, Classification and Evolution of Conopeptides [PDF]

Journal of Molecular Evolution, 2012
Conopeptides are toxins expressed in the venom duct of cone snails (Conoidea, Conus). These are mostly well-structured peptides and mini-proteins with high potency and selectivity for a broad range of cellular targets. In view of these properties, they are widely used as pharmacological tools and many are candidates for innovative drugs.
Puillandre, N., Koua, D., Favreau, P., Olivera, B., Stöcklin, R.   +4 more
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Novel conopeptides in a form of disulfide-crosslinked dimer

Peptides, 2010
In our present work, seven conotoxins and conopeptides were cloned from four cone snail species based on the M-superfamily signal peptides. Among them, two conopeptides, Vt3.1 and Vt3.2, showed unusual sequence characteristics. Both of them contained two cysteines that are separated by just one non-cysteine residue. In vitro, the chemically synthesized
Can Peng, Zhan-Yun Guo
exaly   +3 more sources

Drugs from the Sea: Conopeptides as Potential Therapeutics

Current Medicinal Chemistry, 2004
Marine cone snails from the genus Conus are estimated to consist of up to 700 species. These predatory molluscs have devised an efficient venom apparatus that allows them to successfully capture polychaete worms, other molluscs or in some cases fish as their primary food sources.
Bruce G, Livett, Ken R, Gayler, Zeinab, Khalil   +2 more
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Conopeptide characterization and classifications: An analysis using ConoServer

Toxicon, 2010
Cone snails are carnivorous marine gastropods that have evolved potent venoms to capture their prey. These venoms comprise a rich and diverse cocktail of peptide toxins, or conopeptides, whose high diversity has arisen from an efficient hypermutation mechanism, combined with a high frequency of post-translational modifications.
Kaas, Quentin, Westermann, Jan-Christoph, Craik, David J.   +2 more
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Determination of disulfide bridge pattern in ω‐conopeptides

International Journal of Peptide and Protein Research, 1995
Synthetic versions of seven naturally occurring ω‐conopeptides were subjected to structural analyses in order to determine their disulfide bridge pattern. The method applied in this study uses a combination of amino‐acid composition and peptide sequence analysis of various peptide fragments generated by different enzymatic digestions.
D, Chung, S, Gaur, J R, Bell, J, Ramachandran, L, Nadasdi   +4 more
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Conopeptides: From deadly venoms to novel therapeutics

Drug Discovery Today, 2000
Marine cone snails have developed many distinct venoms that contain biologically active peptides as part of an envenomation survival strategy for feeding and defense. These peptides, known as conopeptides, have been optimized through evolution to target specific ion channels and receptors with very high affinities and selectivities.
, Shen, , Layer, , McCabe
exaly   +3 more sources

Therapeutic Potential of Cone Snail Venom Peptides (Conopeptides)

Current Topics in Medicinal Chemistry, 2012
Cone snails have evolved many 1000s of small, structurally stable venom peptides (conopeptides) for prey capture and defense. Whilst < 0.1% have been pharmacologically characterised, those with known function typically target membrane proteins of therapeutic importance, including ion channels, transporters and GPCRs. Several conopeptides reduce pain in
Vetter, Irina, Lewis, Richard J.
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Conopeptides as novel options for pain management

Drugs of the Future, 2011
Conopeptides are the peptidic components of the venoms of marine cone snails from the Conus genus. Aside from their natural function in pharmacologically immobilizing prey, they have attracted the attention of drug designers in recent years because of their potency and selectivity at a range of pharmaceutically important targets in mammals, including ...
Daly, N. L., Craik, David J.
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Cardiovascular Effects of ω-Conopeptides in Conscious Rats: Mechanisms of Action

Journal of Cardiovascular Pharmacology, 1992
We examined the effects of omega-conopeptides, a novel class of neuronal voltage-gated calcium channel antagonists, on hemodynamic responses in rats. Intravenous (i.v.) injections of SNX-111 (omega-conopeptide MVIIA) dose-dependently decreased arterial blood pressure (BP) in conscious rats. Intracerebroventricular (i.c.v.) SNX-111 injections (580 pmol)
S. Scott Bowersox, Tejinder Singh, Laszlo Nadasdi, Zofia Zukowska-Grojec, Karen Valentino, Brian B. Hoffman   +5 more
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Identification and classification of conopeptides using profile Hidden Markov Models

Biochimica Et Biophysica Acta - Proteins and Proteomics, 2012
Conopeptides are small toxins produced by predatory marine snails of the genus Conus. They are studied with increasing intensity due to their potential in neurosciences and pharmacology. The number of existing conopeptides is estimated to be 1 million, but only about 1000 have been described to date.
Frederique Lisacek, Maido Remm
exaly   +3 more sources