Results 121 to 130 of about 18,612 (160)

Integrative genomic, phylogenetic, and transcriptomic analyses reveal temperature-responsive transient receptor potential (TRP) genes in Pacific abalone Haliotis discus hannai. [PDF]

BMC Ecol Evol
Kim MA, Sohn YC.
europepmc   +1 more source

Fingerprint Analysis and Comparison of Activity Differences of Crude Venom from Five Species of Vermivorous Cone Snail in the South China Sea. [PDF]

Mar Drugs
Sun S, Liao Y, Fu J, Liang Y, Chen Y, Mao K, Gao B.   +6 more
europepmc   +1 more source

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Conotoxins down under

Toxicon, 2006
In the four decades since toxinologists in Australia and elsewhere started to investigate the active constituents of venomous cone snails, a wealth of information has emerged on the various classes of peptides and proteins that make their venoms such potent bioactive cocktails.
Raymond S, Norton, Baldomero M, Olivera
openaire   +2 more sources

I‐conotoxin superfamily revisited

Journal of Peptide Science, 2006
AbstractThe I‐conotoxin superfamily (I‐Ctx) is known to have four disulfide bonds with the cysteine arrangement C‐C‐CC‐CC‐C‐C, and the members inhibit or modify ion channels of nerve cells. Recently, Olivera and co‐workers (FEBS J. 2005; 272: 4178–4188) have suggested that the previously described I‐Ctx should now be divided into two different gene ...
Gough, Julie, Mondal, Sukanta, Babu, Rajasekaran Mohan, Bhavna, Rajasekaran, Ramakumar, Suryanarayanarao   +4 more
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Conotoxins: Chemistry and Biology

Chemical Reviews, 2019
The venom of the marine predatory cone snails (genus Conus) has evolved for prey capture and defense, providing the basis for survival and rapid diversification of the now estimated 750+ species. A typical Conus venom contains hundreds to thousands of bioactive peptides known as conotoxins.
Ai-Hua Jin, Markus Muttenthaler, Sebastien Dutertre, S.W.A. Himaya, Quentin Kaas, David J. Craik, Richard J. Lewis, Paul F. Alewood   +7 more
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Transforming conotoxins into cyclotides: Backbone cyclization of P‐superfamily conotoxins

Peptide Science, 2015
ABSTRACTPeptide backbone cyclization is a widely used approach to improve the activity and stability of small peptides but until recently it had not been applied to peptides with multiple disulfide bonds. Conotoxins are disulfide‐rich conopeptides derived from the venoms of cone snails that have applications in drug design and development.
Akcan, Muharrem, Clark, Richard J., Daly, Norelle L., Conibear, Anne C., de Faoite, Andrew, Heghinian, Mari D., Sahil, Talwar, Adams, David J., Marí, Frank, Craik, David J.   +9 more
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Metamorphoses of a Conotoxin

1996
Venom is a mixture of various substances produced in a specific gland in the body of the venomous animal and introduced through a piercing injecting mechanism into the body of another animal in order to paralyze it or to kill it. In nature, venoms are employed by slow predatory animals in order to capture through an immediate paralysis their relatively
E, Zlotkin, D, Gordon, I, Napchi-Shichor, M, Fainzilber   +3 more
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Conotoxins and their regulatory considerations

Regulatory Toxicology and Pharmacology, 2014
Venom derived peptides from marine cone snails, conotoxins, have demonstrated unique pharmacological targeting properties that have been pivotal in advancing medical research. The awareness of their true toxic origins and potent pharmacological nature is emphasized by their 'select agent' classification by the US Centers for Disease Control and ...
Parashar Thapa, Michael J. Espiritu, Chino C. Cabalteja, Jon-Paul Bingham   +3 more
openaire   +2 more sources

Conotoxin-sensitive and conotoxin-resistant Ca2+ currents in fish retinal ganglion cells

Journal of Neurobiology, 1996
Using whole-cell patch-clamp methods, we tested whether omega-toxins from Conus block voltage-gated Ca2+ currents in teleost central neurons. The fractions omega-CTx-GVIA and omega-CTx-MVIIC, together with omega-toxins from Agelenopsis, the dihydropyridine BAY-K-8644, and voltage steps, produced effects indicating three types of Ca2+ current in ...
V P, Bindokas, A T, Ishida
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Conotoxins: natural product drug leads

Natural Product Reports, 2009
Venomous marine cone snails harbour a variety of small disulfide-rich peptides called conotoxins, which target a broad range of ion channels, membrane receptors, and transporters. More than 700 species of Conus are thought to exist, each expressing a wide array of different peptides.
Halai, Reena, Craik, David J.
openaire   +3 more sources