Results 181 to 190 of about 24,889 (220)
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Conotoxins-New Vistas for Peptide Therapeutics
Current Pharmaceutical Design, 2000There are approximately 500 species of predatory cone snails within the genus Conus. They comprise what is arguably the largest single genus of marine animals alive today. It has been estimated that the venom of each Conus species has between 50 and 200 components. These highly constrained sulfur rich components or conotoxins represent a unique arsenal
R M, Jones, G, Bulaj
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1997
Abstract The α-conotoxins are probably the largest family of paralytic neurotoxins found in the venoms of cone snails (genus Conus), a very successful group of predatory molluscs comprising c. 500 species (Olivera et al. 1985; Myers et al. 1991).
B Olivera, J M McIntosh
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Abstract The α-conotoxins are probably the largest family of paralytic neurotoxins found in the venoms of cone snails (genus Conus), a very successful group of predatory molluscs comprising c. 500 species (Olivera et al. 1985; Myers et al. 1991).
B Olivera, J M McIntosh
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THE CHARACTERIZATION OF CONOTOXINS§
Journal of Toxicology: Toxin Reviews, 2000Conotoxins are peptide toxins synthesized by marine cone snails for both prey entrapment and defense. The peptides, when injected into the prey, cause immobilization and death. Cone snails are widely distributed in tropical waters, their prey includes fish, worms and other marine snails. The peptide toxins have very high specificity and selectivity for
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1997
Abstract The ω-conotoxins are a major family of paralytic neurotoxins produced in the venoms of various species of marine gastropods belonging to the genus Conus. At this time, the most widely known of these peptides is ω-conotoxin Gv1A (wGv1A), which has 27 amino acids and three disulfide linkages; in many scientific publications, the ...
B M Olivera, J S Imperial, D Yoshikami
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Abstract The ω-conotoxins are a major family of paralytic neurotoxins produced in the venoms of various species of marine gastropods belonging to the genus Conus. At this time, the most widely known of these peptides is ω-conotoxin Gv1A (wGv1A), which has 27 amino acids and three disulfide linkages; in many scientific publications, the ...
B M Olivera, J S Imperial, D Yoshikami
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Conotoxins: Molecular and Therapeutic Targets
2009Marine molluscs known as cone snails produce beautiful shells and a complex array of over 50,000 venom peptides evolved for prey capture and defence. Many of these peptides selectively modulate ion channels and transporters, making them a valuable source of new ligands for studying the role these targets play in normal and disease physiology.
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μ-Conotoxins (Conus geographus)
1997Abstract μ-Conotoxins are small basic peptides that inhibit the action potential of skeletal muscle by blocking voltagegated sodium channels (Cruz et al. 1985; Gray et al. 1988). Three major homologues and four minor under hydroxylated forms (see Table 1) have been found in the venom of the most dangerous Conus species, C.
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