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Journal of Medicinal Chemistry, 2008
Alpha-conotoxins are competitive antagonists of nicotinic acetylcholine receptors (nAChRs). The majority of currently characterized alpha-conotoxins have a 4/7 loop size, and the major features of neuronal alpha-conotoxins include a globular disulfide connectivity and a helical structure centered around the third of their four cysteine residues.
Jin, Ai-Hua +8 more
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Alpha-conotoxins are competitive antagonists of nicotinic acetylcholine receptors (nAChRs). The majority of currently characterized alpha-conotoxins have a 4/7 loop size, and the major features of neuronal alpha-conotoxins include a globular disulfide connectivity and a helical structure centered around the third of their four cysteine residues.
Jin, Ai-Hua +8 more
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THE CHARACTERIZATION OF CONOTOXINS§
Journal of Toxicology: Toxin Reviews, 2000Conotoxins are peptide toxins synthesized by marine cone snails for both prey entrapment and defense. The peptides, when injected into the prey, cause immobilization and death. Cone snails are widely distributed in tropical waters, their prey includes fish, worms and other marine snails. The peptide toxins have very high specificity and selectivity for
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Current Topics in Medicinal Chemistry, 2012
It is known that potassium channels are important for cell proliferation. HERG, a potassium channel protein, is a transmembrane protein, which increases in concentration on the cell surface of cancer cells. Apart from cancer cells, this protein is found only in the brain & heart tissue, in very low number.
Kirtan, Dave, Anasuya, Lahiry
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It is known that potassium channels are important for cell proliferation. HERG, a potassium channel protein, is a transmembrane protein, which increases in concentration on the cell surface of cancer cells. Apart from cancer cells, this protein is found only in the brain & heart tissue, in very low number.
Kirtan, Dave, Anasuya, Lahiry
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2000
Abstract Conotoxins are small, disulfide-rich peptides produced by venomous marine snails belonging to the genus Conus (“cone snails”) (2,18,21). There are likely to be ca. 500 different species of cone snails; every one is venomous and produces a large number of conotoxins. The venoms of cone snails (“Conus venoms”) typically contain
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Abstract Conotoxins are small, disulfide-rich peptides produced by venomous marine snails belonging to the genus Conus (“cone snails”) (2,18,21). There are likely to be ca. 500 different species of cone snails; every one is venomous and produces a large number of conotoxins. The venoms of cone snails (“Conus venoms”) typically contain
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Conotoxin-sensitive and conotoxin-resistant Ca2+ currents in fish retinal ganglion cells
Journal of Neurobiology, 1996Using whole-cell patch-clamp methods, we tested whether omega-toxins from Conus block voltage-gated Ca2+ currents in teleost central neurons. The fractions omega-CTx-GVIA and omega-CTx-MVIIC, together with omega-toxins from Agelenopsis, the dihydropyridine BAY-K-8644, and voltage steps, produced effects indicating three types of Ca2+ current in ...
V P, Bindokas, A T, Ishida
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Conotoxins as Research Tools and Drug Leads
Current Protein & Peptide Science, 2005The complex mixture of biologically active peptides that constitute the venom of Conus species provides a rich source of ion channel neurotoxins. These peptides, commonly known as conotoxins, exhibit a high degree of selectivity and potency for different ion channels and their subtypes making them invaluable tools for unravelling the secrets of the ...
Armishaw, Christopher J. +1 more
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Proceedings of the 2019 3rd International Conference on Computational Biology and Bioinformatics, 2019
Conopeptides are small, disulfide-rich polypeptides that have great potential as sources of possible drug candidates due to their activity against membrane receptors and ion channels. A challenge to the faster high-throughput in silico screening of these potential drug candidates is their diversity in structure and relatively low sequence similarity ...
Marineil C. Gomez +5 more
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Conopeptides are small, disulfide-rich polypeptides that have great potential as sources of possible drug candidates due to their activity against membrane receptors and ion channels. A challenge to the faster high-throughput in silico screening of these potential drug candidates is their diversity in structure and relatively low sequence similarity ...
Marineil C. Gomez +5 more
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Structure-Activity Studies on Alpha-Conotoxins
Current Pharmaceutical Design, 2011Conotoxins are small bioactive highly structured peptides from the venom of marine cone snails (genus Conus). Over the past 50 million years these molluscs have developed a complex venom cocktail for each species that is comprised of 100-2000 distinct cysteine- rich peptides for prey capture and defence.
Muttenthaler, Markus +2 more
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Conotoxins: Molecular and Therapeutic Targets
2009Marine molluscs known as cone snails produce beautiful shells and a complex array of over 50,000 venom peptides evolved for prey capture and defence. Many of these peptides selectively modulate ion channels and transporters, making them a valuable source of new ligands for studying the role these targets play in normal and disease physiology.
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Advances in the synthesis and engineering of conotoxins
European Journal of Medicinal ChemistryConotoxins, isolated from the venom of carnivorous marine snails of the Conus genus, are disulfide-rich peptides and proteins with well-defined three-dimensional structures. Conotoxins' ability to target a wide range of ion channels and receptors, including voltage- and ligand-gated ion channels, G protein-coupled receptors, monoamine transporters, and
Thao NT. Ho +3 more
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