Results 161 to 170 of about 22,310 (212)
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1996
Venom is a mixture of various substances produced in a specific gland in the body of the venomous animal and introduced through a piercing injecting mechanism into the body of another animal in order to paralyze it or to kill it. In nature, venoms are employed by slow predatory animals in order to capture through an immediate paralysis their relatively
E, Zlotkin +3 more
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Venom is a mixture of various substances produced in a specific gland in the body of the venomous animal and introduced through a piercing injecting mechanism into the body of another animal in order to paralyze it or to kill it. In nature, venoms are employed by slow predatory animals in order to capture through an immediate paralysis their relatively
E, Zlotkin +3 more
openaire +2 more sources
Transforming conotoxins into cyclotides: Backbone cyclization of P‐superfamily conotoxins
Peptide Science, 2015ABSTRACT Peptide backbone cyclization is a widely used approach to improve the activity and stability of small peptides but until recently it had not been applied to peptides with multiple disulfide bonds. Conotoxins are disulfide‐rich conopeptides derived from the venoms of cone snails that have applications in drug design and ...
Akcan, Muharrem +9 more
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Conotoxins and their regulatory considerations
Regulatory Toxicology and Pharmacology, 2014Venom derived peptides from marine cone snails, conotoxins, have demonstrated unique pharmacological targeting properties that have been pivotal in advancing medical research. The awareness of their true toxic origins and potent pharmacological nature is emphasized by their 'select agent' classification by the US Centers for Disease Control and ...
Parashar Thapa +3 more
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Toxicon, 2006
In the four decades since toxinologists in Australia and elsewhere started to investigate the active constituents of venomous cone snails, a wealth of information has emerged on the various classes of peptides and proteins that make their venoms such potent bioactive cocktails.
Raymond S, Norton, Baldomero M, Olivera
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In the four decades since toxinologists in Australia and elsewhere started to investigate the active constituents of venomous cone snails, a wealth of information has emerged on the various classes of peptides and proteins that make their venoms such potent bioactive cocktails.
Raymond S, Norton, Baldomero M, Olivera
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I‐conotoxin superfamily revisited
Journal of Peptide Science, 2006AbstractThe I‐conotoxin superfamily (I‐Ctx) is known to have four disulfide bonds with the cysteine arrangement C‐C‐CC‐CC‐C‐C, and the members inhibit or modify ion channels of nerve cells. Recently, Olivera and co‐workers (FEBS J. 2005; 272: 4178–4188) have suggested that the previously described I‐Ctx should now be divided into two different gene ...
Gough, Julie; id_orcid 0000-0002-1270-0616 +4 more
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Engineering of Conotoxins for the Treatment of Pain
Current Pharmaceutical Design, 2011The peptides present in the venoms of marine snails are used by the snails to capture prey, but they have also attracted the interest of drug designers because of their potent activity against therapeutically important targets. These peptides are typically disulfiderich and target a wide range of ion channels, transporters and receptors with exquisite ...
Carstens, Bodil B. +5 more
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2000
Abstract Conotoxins are small, disulfide-rich peptides produced by venomous marine snails belonging to the genus Conus (“cone snails”) (2,18,21). There are likely to be ca. 500 different species of cone snails; every one is venomous and produces a large number of conotoxins. The venoms of cone snails (“Conus venoms”) typically contain
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Abstract Conotoxins are small, disulfide-rich peptides produced by venomous marine snails belonging to the genus Conus (“cone snails”) (2,18,21). There are likely to be ca. 500 different species of cone snails; every one is venomous and produces a large number of conotoxins. The venoms of cone snails (“Conus venoms”) typically contain
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THE CHARACTERIZATION OF CONOTOXINS§
Journal of Toxicology: Toxin Reviews, 2000Conotoxins are peptide toxins synthesized by marine cone snails for both prey entrapment and defense. The peptides, when injected into the prey, cause immobilization and death. Cone snails are widely distributed in tropical waters, their prey includes fish, worms and other marine snails. The peptide toxins have very high specificity and selectivity for
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Conotoxins: Molecular and Therapeutic Targets
2009Marine molluscs known as cone snails produce beautiful shells and a complex array of over 50,000 venom peptides evolved for prey capture and defence. Many of these peptides selectively modulate ion channels and transporters, making them a valuable source of new ligands for studying the role these targets play in normal and disease physiology.
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