Results 131 to 140 of about 3,374 (156)

Strategic applications of methylene thioacetal bonds as disulfide surrogates in peptide drug discovery. [PDF]

Front Chem
Zhou Y, Wang D, Xu J, Zheng N.
europepmc   +1 more source

Peptide Toxins from Marine <i>Conus</i> Snails with Activity on Potassium Channels and/or Currents. [PDF]

Toxins (Basel)
Martínez-Hernández L, López-Vera E, Aguilar MB.   +2 more
europepmc   +1 more source

Conotoxins Targeting Voltage-Gated Sodium Ion Channels. [PDF]

Pharmacol Rev
Pei S, Wang N, Mei Z, Zhangsun D, Craik DJ, McIntosh JM, Zhu X, Luo S.   +7 more
europepmc   +1 more source

Multi-omics characterization of toxin expression and producing organs in the predatory gastropods Monoplex corrugatus and Stramonita haemastoma. [PDF]

BMC Genomics
Ringeval A, Modica MV, Kantor Y, Tenorio MJ, Galindo JCG, Puillandre N, Farhat S.   +6 more
europepmc   +1 more source

Structural characterisation of a cysteine-rich conotoxin, sigma(σ)S-GVIIIA, extracted from the defensive venom of the marine cone snail Conus geographus. [PDF]

Biochem J
Peck Y, Wilson D, Lennox-Bulow D, Giribaldi J, Seymour J, Dutertre S, Rosengren K, Liddell M, Daly N.   +8 more
europepmc   +1 more source

δ-Conotoxin Structure Prediction and Analysis through Large-Scale Comparative and Deep Learning Modeling Approaches. [PDF]

Adv Sci (Weinh)
McCarthy S, Gonen S.
europepmc   +1 more source

Prey Shifts Drive Venom Evolution in Cone Snails. [PDF]

Mol Biol Evol
Koch TL, Robinson SD, Salcedo PF, Chase K, Biggs J, Fedosov AE, Yandell M, Olivera BM, Safavi-Hemami H.   +8 more
europepmc   +1 more source

Redox-Active Conopeptide Li520 Has Evolved to Catalyze Oxidative Folding of Conotoxins. [PDF]

ACS Omega
Dhannura S, Shekh S, Dhurjad P, Dolle A, Kakkat S, Vishwajyothi, Vijayasarathy M, Sonti R, Gowd KH.   +8 more
europepmc   +1 more source

Cyclization of conotoxins to improve their biopharmaceutical properties

Toxicon, 2012
Conotoxins are disulfide-rich peptides from the venoms of marine cone snails that are used in prey capture. Due to their exquisite potency and selectivity for different ion channels, receptors and transporters they have attracted much interest as leads ...
Quentin Kaas, Norelle L Daly, Muharrem AKCAN   +2 more
exaly   +2 more sources

Cyclisation of Disulfide-Rich Conotoxins in Drug Design Applications

European Journal of Organic Chemistry, 2016
Conotoxins are disulfide-rich peptides found in the venoms of marine snails of the genus Conus. They have attracted great attention from the pharmaceutical industry because of their potential uses as drug leads, but like most peptides, conotoxins are ...
Yen-Hua Huang, Quentin Kaas, Xiaosa Wu
exaly   +2 more sources