Results 131 to 140 of about 2,164 (171)
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2000
Abstract Conotoxins are small, disulfide-rich peptides produced by venomous marine snails belonging to the genus Conus (“cone snails”) (2,18,21). There are likely to be ca. 500 different species of cone snails; every one is venomous and produces a large number of conotoxins. The venoms of cone snails (“Conus venoms”) typically contain
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Abstract Conotoxins are small, disulfide-rich peptides produced by venomous marine snails belonging to the genus Conus (“cone snails”) (2,18,21). There are likely to be ca. 500 different species of cone snails; every one is venomous and produces a large number of conotoxins. The venoms of cone snails (“Conus venoms”) typically contain
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Conotoxin-sensitive and conotoxin-resistant Ca2+ currents in fish retinal ganglion cells
Journal of Neurobiology, 1996Using whole-cell patch-clamp methods, we tested whether omega-toxins from Conus block voltage-gated Ca2+ currents in teleost central neurons. The fractions omega-CTx-GVIA and omega-CTx-MVIIC, together with omega-toxins from Agelenopsis, the dihydropyridine BAY-K-8644, and voltage steps, produced effects indicating three types of Ca2+ current in ...
V P, Bindokas, A T, Ishida
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Conotoxins as Research Tools and Drug Leads
Current Protein & Peptide Science, 2005The complex mixture of biologically active peptides that constitute the venom of Conus species provides a rich source of ion channel neurotoxins. These peptides, commonly known as conotoxins, exhibit a high degree of selectivity and potency for different ion channels and their subtypes making them invaluable tools for unravelling the secrets of the ...
Armishaw, Christopher J. +1 more
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Proceedings of the 2019 3rd International Conference on Computational Biology and Bioinformatics, 2019
Conopeptides are small, disulfide-rich polypeptides that have great potential as sources of possible drug candidates due to their activity against membrane receptors and ion channels. A challenge to the faster high-throughput in silico screening of these potential drug candidates is their diversity in structure and relatively low sequence similarity ...
Marineil C. Gomez +5 more
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Conopeptides are small, disulfide-rich polypeptides that have great potential as sources of possible drug candidates due to their activity against membrane receptors and ion channels. A challenge to the faster high-throughput in silico screening of these potential drug candidates is their diversity in structure and relatively low sequence similarity ...
Marineil C. Gomez +5 more
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Structure-Activity Studies on Alpha-Conotoxins
Current Pharmaceutical Design, 2011Conotoxins are small bioactive highly structured peptides from the venom of marine cone snails (genus Conus). Over the past 50 million years these molluscs have developed a complex venom cocktail for each species that is comprised of 100-2000 distinct cysteine- rich peptides for prey capture and defence.
Muttenthaler, Markus +2 more
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Conotoxins: Molecular and Therapeutic Targets
2009Marine molluscs known as cone snails produce beautiful shells and a complex array of over 50,000 venom peptides evolved for prey capture and defence. Many of these peptides selectively modulate ion channels and transporters, making them a valuable source of new ligands for studying the role these targets play in normal and disease physiology.
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The international journal of biochemistry & cell biology, 2000
alpha-Conotoxins (alpha-CgTxs) are a family of Cys-enriched peptides found in several marine snails from the genus Conus. These small peptides behave pharmacologically as competitive antagonists of the nicotinic acetylcholine receptor (AChR). The data indicate that (1) alpha-CgTxs are able to discriminate between muscle- and neuronal-type AChRs and ...
H R, Arias, M P, Blanton
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alpha-Conotoxins (alpha-CgTxs) are a family of Cys-enriched peptides found in several marine snails from the genus Conus. These small peptides behave pharmacologically as competitive antagonists of the nicotinic acetylcholine receptor (AChR). The data indicate that (1) alpha-CgTxs are able to discriminate between muscle- and neuronal-type AChRs and ...
H R, Arias, M P, Blanton
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Conotoxin Venom Peptide Therapeutics
2009Venom peptides offer enormous opportunity for the discovery of peptide drug leads. This review focusses on the potential of cone snails that have developed arrays of small peptides as part of highly evolved venoms used for prey capture and defence. Many of these peptides selectively modulate ion channels and transporters, making them a valuable source ...
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