Results 91 to 100 of about 45,599 (229)

Efavirenz and CYP2C9 Genetic Polymorphisms Reduce CYP2C9 Activity in Healthy Participants

Clinical and Translational Science, Volume 19, Issue 2, February 2026.
ABSTRACT Efavirenz's effects on cytochrome P450 2C9 (CYP2C9) activity have not been formally characterized in vivo. We conducted the first clinical drug–drug interaction (DDI) study to test the effect of chronic efavirenz dosing on CYP2C9 activity, using tolbutamide as a selective probe.
Jason D. Kim, Ingrid F. Metzger, Jessica Bo Li Lu, Todd C. Skaar, Zeruesenay Desta   +4 more
wiley   +1 more source

Nucleophosmin 1 induction is an early event in a Phenobarbital induced proliferation response in rat but not human liver 3D microtissues

Toxicology Reports
A key event in the process of rat but not human liver carcinogenesis caused by constitutive androstane receptor activators such as phenobarbital (PB) is hepatocyte proliferation, but the mechanism(s) underpinning this response is not fully understood ...
Matthew Elcombe, Stephanie Wallace, Simon Plummer   +2 more
doaj   +1 more source

The Connection of Azole Fungicides with Xeno-Sensing Nuclear Receptors, Drug Metabolism and Hepatotoxicity

Cells, 2020
Azole fungicides, especially triazole compounds, are widely used in agriculture and as pharmaceuticals. For a considerable number of agricultural azole fungicides, the liver has been identified as the main target organ of toxicity.
Philip Marx-Stoelting, Constanze Knebel, Albert Braeuning   +2 more
doaj   +1 more source

Dual action of oestrogens on the mouse constitutive androstane receptor [PDF]

Biochemical Journal, 2003
mCAR (mouse constitutive androstane receptor; NR1I3) controls the expression of cytochrome P450 as well as other enzymes involved in drug and steroid metabolism. The high basal activity of mCAR can be modulated by inhibitory steroids related to androstenol and by activating xenobiotic chemicals such as 1,4-bis-[2-(3,5-dichloropyridyloxy)]benzene and ...
Janne, Mäkinen, Mika, Reinisalo, Kaisa, Niemi, Pirkko, Viitala, Johanna, Jyrkkärinne, Hinfan, Chung, Olavi, Pelkonen, Paavo, Honkakoski   +7 more
openaire   +2 more sources

The Effect of Ecopipam on the Pharmacokinetics of Concomitant Medications

Clinical and Translational Science, Volume 19, Issue 2, February 2026.
ABSTRACT Ecopipam is a first‐in‐class dopamine D1 receptor antagonist under investigation for the treatment of Tourette syndrome. This open‐label, fixed‐sequence, three‐cohort study evaluated whether ecopipam induces or inhibits cytochrome P450 (CYP) 1A2, CYP2B6, CYP2C19, CYP2D6, CYP3A4, organic anion‐transporting polypeptide (OATP) 1B1, and p ...
Virginia D. Schmith, Danielle Graden, Lauren L. R. Lohmer, Joy Schleyer, Stephen P. Wanaski   +4 more
wiley   +1 more source

Regulation of pregnane-X-receptor, CYP3A and P-glycoprotein genes in the PCB-resistant killifish (Fundulus heteroclitus) population from New Bedford Harbor [PDF]

, 2014
Author Posting. © The Author(s), 2014. This is the author's version of the work. It is posted here by permission of Elsevier for personal use, not for redistribution.
Celander, Malin C., Champlin, Denise, Fernandez-Santoscoy, María, Grans, Johanna, Hahn, Mark E., Jayaraman, Saro, Karchner, Sibel I., Nacci, Diane E., Stegeman, John J., Wassmur, Britt, Woodin, Bruce R., Zanette, Juliano   +11 more
core   +1 more source

Metformin represses drug – induced expression of CYP2B6 by the constitutive androstane receptor phosphorylation

Ожирение и метаболизм, 2014
Currently, metformin is a major hypoglycemic agents for the treatment of type 2 diabetes. The main antihyperglycemic effect of metformin - suppression of hepatic gluconeogenesis and glycolysis.

doaj   +1 more source

Updated peer review of the pesticide risk assessment of the active substance pydiflumetofen

EFSA Journal, Volume 24, Issue 1, January 2026.
Abstract The conclusions of the European Food Safety Authority (EFSA) following the peer review of the initial risk assessments carried out by the competent authority of the rapporteur Member State France and co‐rapporteur Member State Austria for the pesticide active substance pydiflumetofen and the assessment of applications for maximum residue ...
European Food Safety Authority (EFSA), Fernando Álvarez, Maria Arena, Domenica Auteri, Sofia Batista Leite, Marco Binaglia, Anna Federica Castoldi, Arianna Chiusolo, Angelo Colagiorgi, Mathilde Colas, Federica Crivellente, Chloe De Lentdecker, Isabella De Magistris, Mark Egsmose, Gabriella Fait, Franco Ferilli, Varvara Gouliarmou, Katrin Halling, Laia Herrero Nogareda, Alessio Ippolito, Frederique Istace, Samira Jarrah, Dimitra Kardassi, Aude Kienzler, Anna Lanzoni, Roberto Lava, Renata Leuschner, Alberto Linguadoca, Jochem Louisse, Christopher Lythgo, Oriol Magrans, Iris Mangas, Andrea Mioč, Ileana Miron, Tunde Molnar, Laura Padovani, Vincenzo Padricello, Martina Panzarea, Juan Manuel Parra Morte, Simone Rizzuto, Anamarija Romac, Agnès Rortais, Miguel Santos, Rositsa Serafimova, Rachel Sharp, Csaba Szentes, Andrea Terron, Anne Theobald, Manuela Tiramani, Giorgia Vianello, Laura Villamar‐Bouza   +50 more
wiley   +1 more source

Constitutive androstane receptor mediates PCB-induced disruption of retinoid homeostasis. [PDF]

Toxicol Appl Pharmacol, 2019
Environmental exposure to polychlorinated biphenyls (PCBs) is associated with an increased risk of incidence of metabolic disease, however the molecular mechanisms underlying this phenomenon are not fully understood. Our study provides new insights into molecular interactions between PCBs and retinoids (vitamin A and its metabolites) by defining a role
Shmarakov IO, Lee YJ, Jiang H, Blaner WS.   +3 more
europepmc   +4 more sources

Secondary metabolites with ecologic and medicinal implications in Anthemis cretica subsp. petraea from Majella National Park [PDF]

, 2016
Anthemis cretica subsp. petraea (Ten.) Greuter is a plant belonging to the Asteraceae family and endemic of central Italy. In this paper, the first analysisof the ethanolic fraction of samples collected in the Majella National Park is reported.
Alessandro Venditti, Armandodoriano Bianco, Claudio Frezza, Giacomo Rossi, Giampiero Ciaschetti, Mauro Serafini, Mirella Di Cecco, null null   +7 more
core   +2 more sources