Results 91 to 100 of about 69,599 (292)
Direct imaging of lateral movements of AMPA receptors inside synapses [PDF]
EMBO J 22, 18 (15/09/2003) 4656-65, 2007 Trafficking of AMPA receptors in and out of synapses is crucial for synaptic plasticity. Previous studies have focused on the role of endo/exocytosis processes or that of lateral diffusion of extra-synaptic receptors. We have now directly imaged AMPAR movements inside and outside synapses of live neurons using single-molecule fluorescence microscopy ...
arxiv +1 more source
Synthesis and in vivo evaluation of non-hepatotoxic acetaminophen analogs [PDF]
, 2007 A series of acetaminophen (APAP) analogs, 2-(1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)-N-(4-hydroxyphenyl)alkanecarboxamides, bearing a heterocyclic moiety linked to the p-acylaminophenol fragment, were prepared in a general project to develop APAP ...
Bazan, Nicolas G. +11 more
core +3 more sources
Ожирение и метаболизм, 2014 Currently, metformin is a major hypoglycemic agents for the treatment of type 2 diabetes. The main antihyperglycemic effect of metformin - suppression of hepatic gluconeogenesis and glycolysis.
doaj +1 more source
Pharmacology and relevant drug interactions of metamizole
British Journal of Clinical Pharmacology, EarlyView.Metamizole is a frequently prescribed analgesic because of its favourable benefit/risk ratio compared with classic NSAIDs. However, increasing research shows that metamizole displays several drug interactions that are relevant to clinical practice. We reviewed the literature to summarize the pharmacology and most clinically relevant drug interactions ...
David J. Brinkman +3 more
wiley +1 more source
Phenytoin Induction of the Cyp2c37 Gene Is Mediated by the Constitutive Androstane Receptor [PDF]
Drug Metabolism and Disposition, 2006 The CYP2C subfamily of cytochrome P450 monooxygenases is responsible for the metabolism of approximately 20% of therapeutic drugs and many endogenous compounds in humans. These enzymes can be induced by prior treatment with drugs, resulting in changes in drug efficacy.
Stephen S. G. Ferguson +3 more
openaire +3 more sources
Trait-space patterning and the role of feedback in antigen-immunity coevolution [PDF]
Phys. Rev. Research 1, 033164 (2019), 2019 Coevolutionary arms races form between interacting populations that constitute each other's environment and respond to mutual changes. This inherently far-from-equilibrium process finds striking manifestations in the adaptive immune system, where highly variable antigens and a finite repertoire of immune receptors coevolve on comparable timescales ...
arxiv +1 more source
Drug Testing and Analysis, EarlyView.A survey of 200 sports supplements purchased online in Australia and analysed for WADA Prohibited Substances. Athlete education regarding the use of sports supplements remains a high priority as 35% of the products contained WADA Prohibited Substances. ABSTRACT Sports supplements are used extensively by people involved in competitive sports. However, a
Louise Barker +4 more
wiley +1 more source
Chemotactic crawling of multivalent vesicles along ligand-density gradients [PDF]
arXiv, 2023 Living cells are capable of interacting with their environments in a variety of ways, including cell signalling, adhesion, and directed motion. These behaviours are often mediated by receptor molecules embedded in the cell membrane, which bind specific ligands.
arxiv
iMetaOmics, Volume 2, Issue 2, June 2025.In this study, we explored the therapeutic effects of Parabacteroides goldsteinii (P. goldsteinii) on colitis and its underlying mechanisms. Our results indicate a significant reduction of P. goldsteinii in the stools of inflammatory bowel disease patients. We demonstrate the therapeutic potential of P.
Fujian Qin +7 more
wiley +1 more source
Atypical functions of xenobiotic receptors in lipid and glucose metabolism
Medical Review, 2022 Xenobiotic receptors are traditionally defined as xenobiotic chemical-sensing receptors, the activation of which transcriptionally regulates the expression of enzymes and transporters involved in the metabolism and disposition of xenobiotics.
Wang Jingyuan, Lu Peipei, Xie Wen
doaj +1 more source