Results 101 to 110 of about 69,599 (292)

Use of quercetin in animal feed : effects on the P-gp expression and pharmacokinetics of orally administrated enrofloxacin in chicken [PDF]

, 2018
Modulation of P-glycoprotein (P-gp, encoded by Mdr1) by xenobiotics plays central role in pharmacokinetics of various drugs. Quercetin has a potential to modulate P-gp in rodents, however, its effects on P-gp modulation in chicken are still unclear ...
A Pedretti, AM Haritova, C Issa, CH Nightingale, D Carvalho, D Osguthorpe, D Sadowski, E Abu-Basha, E Chieli, H Elsheikh, J Dupuy, J Formica, J Sugatani, J Yang, JS Choi, JS Choi, K Lohner, K Yamaoka, KJ Livak, L Gibellini, L Li, LR Fortunato, M Goliomytis, M Guo, M Guo, M Nair, MD Hanwell, MM Pulido, MP Nair, MR Durk, O Trott, P Zakeri-Milani, P Zakeri-Milani, PV Balimane, R Walker, S Borska, S Kim, S Wang, SL Hsiu, T Guo, T Guo, TT Cushnie, V Madgula, W Li, X Liu, Y Hee Choi, YJ Chae, YQ Shan, Z Chen   +48 more
core   +2 more sources

Specific effects on liver relevant for performing a dietary cumulative risk assessment of pesticide residues

EFSA Journal, Volume 23, Issue 5, May 2025.
Abstract According to the ‘EFSA‐SANTE Action Plan on Cumulative Risk Assessment for pesticides residues’, EFSA initiated a retrospective cumulative risk assessment (CRA) of the effects of pesticide residues on the liver. For this CRA, EFSA identified the following liver‐specific effects in accordance with the International Harmonisation of Nomenclature
European Food Safety Authority (EFSA), Anna F. Castoldi, Tamara Coja, Anna Lanzoni, Kyriaki Machera, Luc Mohimont, Monica Nepal, Camilla Recordati, Federica Crivellente   +8 more
wiley   +1 more source

1I. Vitamin D receptor-like receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database [PDF]

, 2019
Vitamin D (VDR), Pregnane X (PXR) and Constitutive Androstane (CAR) receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Nuclear Hormone Receptors [47]) are members of the NR1I family of nuclear receptors, which form heterodimers with ...
Christakos, Sylvia
core   +2 more sources

The Role of Cholesterol Metabolism and Its Regulation in Tumor Development

Cancer Medicine, Volume 14, Issue 7, April 2025.
ABSTRACT Background Within the tumor microenvironment, tumor cells undergo metabolic reprogramming of cholesterol due to intrinsic cellular alterations and changes in the extracellular milieu. Furthermore, cholesterol reprogramming within this microenvironment influences the immune landscape of tumors, facilitating immune evasion and consequently ...
Yongmei Wu, Wenqian Song, Min Su, Jing He, Rong Hu, Youbo Zhao   +5 more
wiley   +1 more source

55484 Dual activation of CAR and Nrf2 improves the efficacy: toxicity ratio of cyclophosphamide and doxorubicin-based treatment of TNBC

Journal of Clinical and Translational Science, 2021
IMPACT: Triple negative breast cancer (TNBC) affects 10-20% of women with breast cancer and is biologically more aggressive than other subtypes. The novel compound we have developed, DL7076, would give clinicians a vital strategy to improve the commonly ...
Sydney Stern, Dongdong Liang, Linhao Li, Ritika Kurian, Caitlin Lynch, Scott Heyward, Ajoke Kareem, Young Chun, Charles Hong, Fengtian Xue, Hongbing Wang   +10 more
doaj   +1 more source

Activation of Nuclear Receptor CAR: A Pathway to Delay Aging through Enhanced Capacity for Xenobiotic Resistance

Advanced Science, Volume 12, Issue 12, March 27, 2025.
The authors uncovered that targeting the constitutive androstane receptor (CAR) might decelerate the aging process. Employing models like C. elegans and mice, they determined that CAR agonists CITCO and TCPOBOP can extend both the lifespan and healthspan.
Jing Yu, Xiaoyan Gao, Hang Shi, Lijun Zhang, Wenlong Nie, Ruochen Zhang, Minglv Fang, Ying Liu, Yingxuan Yan, Bingbing Fan, Chengyuan Wu, Cheng Huang, Shengjie Fan   +12 more
wiley   +1 more source

Structure and Function of the Nuclear Receptor Constitutive Androstane Receptor

YAKUGAKU ZASSHI, 2016
Animal defense mechanisms against both endogenous and exogenous toxic compounds function mainly through receptor-type transcription factors, including the constitutive androstane receptor (CAR). Following xenobiotic stimulation, CAR translocates into the nucleus and transactivates its target genes including oxygenic and conjugative enzymes and ...
openaire   +4 more sources

Dehydroepiandrosterone Induces Human CYP2B6 through the Constitutive Androstane Receptor [PDF]

Drug Metabolism and Disposition, 2007
Dehydroepiandrosterone (DHEA), the major precursor of androgens and estrogens, has several beneficial effects on the immune system, on memory function, and in modulating the effects of diabetes, obesity, and chemical carcinogenesis. Treatment of rats with DHEA influences expression of cytochrome P450 (P450) genes, including peroxisome proliferator ...
Katalin Monostory, Viola Tamasi, Krisztina Kohalmy, Jean-Marc Pascussi, Eniko Sárváry, Urs A. Meyer, Pálma Porrogi, Russell A. Prough, Damjana Rozman, László Kóbori   +9 more
openaire   +3 more sources

Stereoisomerization of human constitutive androstane receptor agonist CITCO

Tetrahedron, 2021
Abstract CITCO (6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde-O-(3,4-dichlorobenzyl) oxime) is a widely used agonist of the human constitutive androstane receptor (hCAR), a key hepatic xenobiotic sensor protein with emerging therapeutic indications. To address the insufficient stability of CITCO, which limits its therapeutic potential,
Benjamin Diethelm-Varela, Anmol Kumar, Caitlin Lynch, Gregory H. Imler, Jeffrey R. Deschamps, Yue Li, Menghang Xia, Alexander D. MacKerell, Fengtian Xue   +8 more
openaire   +3 more sources

Replicate immunosequencing as a robust probe of B cell repertoire diversity [PDF]

, 2014
Fundamental to quantitative characterization of the B cell receptor repertoire is clonal diversity - the number of distinct somatically recombined receptors present in the repertoire and their relative abundances, defining the search space available for immune response.
arxiv   +1 more source