Results 101 to 110 of about 45,599 (229)

Prediction Model with High-Performance Constitutive Androstane Receptor (CAR) Using DeepSnap-Deep Learning Approach from the Tox21 10K Compound Library

International Journal of Molecular Sciences, 2019
The constitutive androstane receptor (CAR) plays pivotal roles in drug-induced liver injury through the transcriptional regulation of drug-metabolizing enzymes and transporters.
Y. Matsuzaka, Y. Uesawa
semanticscholar   +1 more source

A Population Pharmacokinetic Approach to Understand the Effect of Efavirenz on CYP3A Activity in Healthy Volunteers Using Midazolam as a Probe

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 12, Page 2095-2106, December 2025.
ABSTRACT Efavirenz induces and inhibits multiple drug‐metabolizing enzymes, contributing to significant drug–drug interactions. This study quantified the impact of multiple doses of efavirenz on CYP3A activity via midazolam metabolism using a population pharmacokinetic approach.
Kimberly S. Collins, Blessed W. Aruldhas, Ingrid F. Metzger, Jessica B. L. Lu, Michael A. Heathman, Sara K. Quinney, Zeruesenay Desta   +6 more
wiley   +1 more source

The transcription factor ATF5: role in cellular differentiation, stress responses, and cancer. [PDF]

, 2017
Activating transcription factor 5 (ATF5) is a cellular prosurvival transcription factor within the basic leucine zipper (bZip) family that is involved in cellular differentiation and promotes cellular adaptation to stress.
Angelastro, James M, Sears, Thomas K
core   +2 more sources

The Concise Guide to PHARMACOLOGY 2025/26: Nuclear hormone receptors

British Journal of Pharmacology, Volume 182, Issue S1, Page S242-S258, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, John A. Cidlowski, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Laurel Coons, Peter J. Fuller, Kenneth S. Korach, Donald P. McDonell, Robert Oakley, Sarah Radi, Rachid Safi, Frances Sladek, Morag J. Young   +20 more
wiley   +1 more source

Atypical functions of xenobiotic receptors in lipid and glucose metabolism

Medical Review, 2022
Xenobiotic receptors are traditionally defined as xenobiotic chemical-sensing receptors, the activation of which transcriptionally regulates the expression of enzymes and transporters involved in the metabolism and disposition of xenobiotics.
Wang Jingyuan, Lu Peipei, Xie Wen
doaj   +1 more source

Investigation of hepatocyte signaling pathways in chronic kidney disease : clinical and experimental studies [PDF]

, 2016
Chronic kidney disease (CKD) is defined as a loss of renal function from any cause and lasting for more than three months. The CKD phenotype is similar across multiple etiologies, suggesting that renal damage itself is a dominant factor. Thus, regardless
Li, Meng
core   +1 more source

Characterization of DNA Complexes Formed by the Nuclear Receptor Constitutive Androstane Receptor [PDF]

Journal of Biological Chemistry, 2003
The nuclear receptor constitutive androstane receptor (CAR) acts as a xenobiotic sensor and regulates the expression of enzymes, such as several cytochromes P450s and the UDP-glucuronosyltransferase (UGT) type 1A1. CAR binds as a heterodimer with the retinoid X receptor (RXR) to specific DNA sites, called response elements (REs).
Christian, Frank, Manuel Macias, Gonzalez, Carita, Oinonen, Thomas W, Dunlop, Carsten, Carlberg   +4 more
openaire   +2 more sources

The assessment for potential thyroid‐mediated endocrine disruption in amphibians: Clarification on the use of new methods and on the interpretation of changes in thyroid histology

EFSA Journal, Volume 23, Issue 12, December 2025.
Abstract Amphibians (specifically Xenopus laevis) are used as the model species to assess potential endocrine‐disrupting properties in non‐mammalian species through thyroid modality. The amphibian metamorphosis assay is the most frequently available test.
European Food Safety Authority (EFSA), Lisa Baumann, Alice Baynes, Susanne Hougaard Bennekou, Kevin Crofton, Zhichao Dang, Sigmund Degitz, Jean‐Baptiste Fini, Mary Gilbert, Henrik Holbech, Andrea Terron, Majorie Van Duursen, Emily McVey, Maria Arena, Aude Kienzler, Simone Rizzuto, Laura Villamar Bouza, Martin Wilks   +17 more
wiley   +1 more source

Use of quercetin in animal feed : effects on the P-gp expression and pharmacokinetics of orally administrated enrofloxacin in chicken [PDF]

, 2018
Modulation of P-glycoprotein (P-gp, encoded by Mdr1) by xenobiotics plays central role in pharmacokinetics of various drugs. Quercetin has a potential to modulate P-gp in rodents, however, its effects on P-gp modulation in chicken are still unclear ...
A Pedretti, AM Haritova, C Issa, CH Nightingale, D Carvalho, D Osguthorpe, D Sadowski, E Abu-Basha, E Chieli, H Elsheikh, J Dupuy, J Formica, J Sugatani, J Yang, JS Choi, JS Choi, K Lohner, K Yamaoka, KJ Livak, L Gibellini, L Li, LR Fortunato, M Goliomytis, M Guo, M Guo, M Nair, MD Hanwell, MM Pulido, MP Nair, MR Durk, O Trott, P Zakeri-Milani, P Zakeri-Milani, PV Balimane, R Walker, S Borska, S Kim, S Wang, SL Hsiu, T Guo, T Guo, TT Cushnie, V Madgula, W Li, X Liu, Y Hee Choi, YJ Chae, YQ Shan, Z Chen   +48 more
core   +3 more sources

The Nrf2 Activator Oltipraz Also Activates the Constitutive Androstane Receptor [PDF]

Drug Metabolism and Disposition, 2008
Oltipraz (OPZ) is a well known inducer of NAD(P)H:quinone oxidoreductase (NQO1) along with other enzymes that comprise the nuclear factor E2-related factor 2 (Nrf2) battery of detoxification genes. However, OPZ treatment also induces expression of CYP2B, a gene regulated by the constitutive androstane receptor (CAR).
Matthew D, Merrell, Jonathan P, Jackson, Lisa M, Augustine, Craig D, Fisher, Angela L, Slitt, Jonathan M, Maher, Wendong, Huang, David D, Moore, Youcai, Zhang, Curtis D, Klaassen, Nathan J, Cherrington   +10 more
openaire   +2 more sources