Results 111 to 120 of about 69,599 (292)

Regulation of human CYP2C9 expression by electrophilic stress involves AP-1 activation and DNA looping [PDF]

, 2014
CYP2C9 and CYP2C19 are important human enzymes that metabolize therapeutic drugs, environmental chemicals and physiologically important endogenous compounds.
Goldstein, J. A., Makia, N. L., Monostory, K., Prough, R. A., Surapureddi, S.   +4 more
core   +1 more source

Evaluation of In Vitro and In Vivo Pharmacological Activity of Elatostema sessile With In Silico Approaches

Food Science &Nutrition, Volume 13, Issue 3, March 2025.
Elatostema sessile exhibits remarkable antioxidant properties, effectively scavenging free radicals and reducing oxidative stress, crucial in preventing various diseases. Additionally, its cytotoxic potential suggests promising anticancer applications, while its analgesic effects help in pain management by modulating nociceptive pathways.
Aninda Kumar Nath, Saima Sultana Alam, Joushan Ara, Md. Mustafiz Chowdhury, Ummah Tasnim Nisat, Mohammad Jamal Uddin, Md. Tanvir Chowdhury, Sabbir Khan, Mycal Dutta   +8 more
wiley   +1 more source

Multi-species Analyses of Direct Activators of the Constitutive Androstane Receptor [PDF]

Toxicological Sciences, 2011
The constitutive androstane receptor (CAR; NR1I3) is a member of the nuclear receptor superfamily and functions as an important xenochemical sensor and transcriptional modulator in mammalian cells. Upon chemical activation, CAR undergoes nuclear translocation and heterodimerization with the retinoid X receptor subsequent to its DNA target interaction ...
Richard C. Peffer, Elizabeth M. Laurenzana, Curtis J. Omiecinski, Denise M. Coslo, Tao Chen   +4 more
openaire   +3 more sources

Large number of receptors may reduce cellular response time variation [PDF]

Physical biology 10 (3), 035008, 2013, 2012
Cells often have tens of thousands of receptors, even though only a few activated receptors can trigger full cellular responses. Reasons for the overabundance of receptors remain unclear. We suggest that, in certain conditions, the large number of receptors results in a competition among receptors to be the first to activate the cell.
arxiv   +1 more source

The effect of carbamazepine, a strong CYP3A inducer, on the pharmacokinetics of zongertinib in healthy male volunteers

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 45, Issue 2, Page 94-103, February 2025.
Abstract Introduction Zongertinib (BI 1810631) is a potent, selective, and epidermal growth factor receptor (EGFR) wild‐type sparing human epidermal growth factor receptor 2 (HER2) inhibitor. Based on in vitro data, the oxidative hepatic metabolism of zongertinib is principally driven by cytochrome P450 (CYP) 3A4/5.
Xiaofan Tian, Habib Esmaeili, David Minich, Friedeborg Seitz, Philipp M. Roessner, Sven Wind, Rolf Grempler, Guanfa Gan, Tom S. Chan, Mazyar Mahmoudi, Behbood Sadrolhefazi, Fabian Müller   +11 more
wiley   +1 more source

Where is the mind within the brain? Transient selection of subnetworks by metabotropic receptors and G protein-gated ion channels [PDF]

arXiv, 2022
Perhaps the most important question posed by brain research is: How the brain gives rise to the mind. To answer this question, we have primarily relied on the connectionist paradigm: The brain's entire knowledge and thinking skills are thought to be stored in the connections; and the mental operations are executed by network computations.
arxiv  

Standard Protocols for Characterising Primary and In Vitro‐Generated Human Hepatocytes

Journal of Cellular and Molecular Medicine, Volume 29, Issue 3, February 2025.
ABSTRACT Hepatocyte‐like cells (HLCs) derived from pluripotent stem cells (PSCs) or direct reprogramming are an unlimited source of human hepatocytes for biomedical applications. HLCs are used to model human diseases, develop precise drugs and establish groundbreaking regenerative cell‐based therapies.
Zahra Heydari, Roberto Gramignoli, Abbas Piryaei, Ensieh Zahmatkesh, Paria Pooyan, Homeyra Seydi, Andreas Nussler, Dagmara Szkolnicka, Hassan Rashidi, Mustapha Najimi, David C. Hay, Massoud Vosough   +11 more
wiley   +1 more source

Regulation of CAR and PXR Expression in Health and Disease

Cells, 2020
Pregnane X receptor (PXR, NR1I2) and constitutive androstane receptor (CAR, NR1I3) are members of the nuclear receptor superfamily that mainly act as ligand-activated transcription factors. Their functions have long been associated with the regulation of
Martine Daujat-Chavanieu, Sabine Gerbal-Chaloin   +1 more
doaj   +1 more source

Xanthohumol ameliorates Diet-Induced Liver Dysfunction via Farnesoid X Receptor-Dependent and Independent Signaling

Frontiers in Pharmacology, 2021
The farnesoid X receptor (FXR) plays a critical role in the regulation of lipid and bile acid (BA) homeostasis. Hepatic FXR loss results in lipid and BA accumulation, and progression from hepatic steatosis to nonalcoholic steatohepatitis (NASH).
Ines L. Paraiso, Ines L. Paraiso, Thai Q. Tran, Armando Alcazar Magana, Armando Alcazar Magana, Armando Alcazar Magana, Payel Kundu, Jaewoo Choi, Claudia S. Maier, Gerd Bobe, Gerd Bobe, Jacob Raber, Jacob Raber, Jacob Raber, Chrissa Kioussi, Jan F. Stevens, Jan F. Stevens   +16 more
doaj   +1 more source

T-Cell Receptor Optimization with Reinforcement Learning and Mutation Policies for Precesion Immunotherapy [PDF]

arXiv, 2023
T cells monitor the health status of cells by identifying foreign peptides displayed on their surface. T-cell receptors (TCRs), which are protein complexes found on the surface of T cells, are able to bind to these peptides. This process is known as TCR recognition and constitutes a key step for immune response.
arxiv