Results 121 to 130 of about 69,599 (292)
5-hydroxymethylcytosine profiling as an indicator of cellular state [PDF]
, 2013 A Laird is supported by the Medical Research Council Scottish Clinical Pharmacology and Pathology Programme, The Royal College of Surgeons of Edinburgh Robertson’s Trust and The Melville Trust for the Care and Cure of Cancer.
Harrison, David J. +3 more
core +1 more source
Risks to human and animal health from the presence of bromide in food and feed
EFSA Journal, Volume 23, Issue 1, January 2025.Abstract The European Commission mandated EFSA to assess the toxicity of bromide, the existing maximum residue levels (MRLs), and possible transfer from feed into food of animal origin. The critical effects of bromide in experimental animals are on the thyroid and central nervous system.
EFSA Scientific Committee +34 more
wiley +1 more source
Algebraic study of receptor-ligand systems: a dose-response analysis [PDF]
arXiv, 2022 The study of a receptor-ligand system generally relies on the analysis of its dose-response (or concentration-effect) curve, which quantifies the relation between ligand concentration and the biological effect (or cellular response) induced when binding its specific cell surface receptor.
arxiv
International Journal of Molecular Sciences, 2019 The constitutive androstane receptor (CAR) plays pivotal roles in drug-induced liver injury through the transcriptional regulation of drug-metabolizing enzymes and transporters.
Y. Matsuzaka, Y. Uesawa
semanticscholar +1 more source
Diurnal difference in CAR mRNA expression [PDF]
, 2004 BACKGROUND: The constitutive androstane receptor (CAR, NR1I3) plays a key role in the transcriptional activation of genes that encode xenobiotic/steroid and drug metabolizing enzymes. RESULTS: The expression of CAR mRNA throughout the circadian rhythm is
Hiromasa, Takuya +4 more
core +2 more sources
Kernel‐Based Bootstrap Synthetic Data to Estimate Measurement Uncertainty in Analytical Sciences
Journal of Chemometrics, Volume 38, Issue 12, December 2024.ABSTRACT Measurement uncertainty (MU) is becoming a key figure of merit for analytical methods, and estimating MU from method validation data is cost‐effective and practical. Since MU can be defined as a coverage interval of a given result, the computation of statistical prediction intervals is a possible approach, but the quality of the intervals is ...
Max Feinberg +3 more
wiley +1 more source
An Introduction to Rule-based Modeling of Immune Receptor Signaling [PDF]
arXiv, 2017 Cells process external and internal signals through chemical interactions. Cells that constitute the immune system (e.g., antigen presenting cell, T-cell, B-cell, mast cell) can have different functions (e.g., adaptive memory, inflammatory response) depending on the type and number of receptor molecules on the cell surface and the specific ...
arxiv
Toxicological Research, 2018 A large number of nongenotoxic chemicals have been shown to increase the incidence of liver tumours in rats and/or mice by a mode of action (MOA) involving activation of the constitutive androstane receptor (CAR).
B. Lake
semanticscholar +1 more source
Sex-related differences in murine hepatic transcriptional and proteomic responses to TCDD [PDF]
, 2015 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is an environmental contaminant that produces myriad toxicities in most mammals. In rodents alone, there is a huge divergence in the toxicological response across species, as well as among different strains ...
Boutros, Paul C. +4 more
core +1 more source
Effects of microRNA on the growth and targeted therapy response on lung cancer
Clinical and Translational Discovery, Volume 4, Issue 6, December 2024.MicroRNAs (miRNAs) regulate the expression of messenger RNAs, which in turn regulate the development of cancer cells. In addition, miRNAs can be used as biomarkers for cancer. Targeted therapies in cancer aim to inhibit specific molecular targets responsible for enhanced tumour growth.
Mengchen Zhu, Yi Jiang, Lingshuang Liu
wiley +1 more source