Results 121 to 130 of about 45,599 (229)
Journal of Food Science, Volume 90, Issue 9, September 2025.ABSTRACT Although Peucedanum japonicum Thunb (PJT) has been used in traditional medicine, PJT root is considered to be agricultural waste, and its benefits have not been explored to date. This study examined the effect of PJT root extract in C57BL/6J mice fed a high‐fat diet (HFD) for 10 weeks and determined the underlying molecular mechanisms based on
Rahmawati Aisyah +9 more
wiley +1 more source
Genetic variants associated with gastrointestinal symptoms in Fabry disease. [PDF]
, 2016 Gastrointestinal symptoms (GIS) are often among the earliest presenting events in Fabry disease (FD), an X-linked lysosomal disorder caused by the deficiency of α-galactosidase A.
Agapito, Giuseppe +14 more
core +1 more source
Navigating Drug–Drug Interactions in Clinical Drug Development: A Tutorial
Clinical and Translational Science, Volume 18, Issue 9, September 2025.ABSTRACT This tutorial provides essential guidelines and insights, in addition to regulatory guidance, for the evaluation of drug–drug interactions (DDIs), with a focus on the tools and timing of assessment critical for effective management of inclusion/exclusion criteria during drug development and accurate labeling of investigational drugs.
Jesmin Lohy Das +2 more
wiley +1 more source
Journal of Veterinary Pharmacology and Therapeutics, Volume 48, Issue 5, Page 345-358, September 2025.ABSTRACT Rifampin is an enigma among antimicrobials. Blood and tissue compartment concentrations are a “moving target” along the treatment course due to the complex pharmacodynamic interactions within the body. Rifampin concomitant therapies are for the prevention and treatment of Rhodococcus equi infection in foals, for nearly 40 years.
Keith Edward Baptiste +4 more
wiley +1 more source
5-hydroxymethylcytosine profiling as an indicator of cellular state [PDF]
, 2013 A Laird is supported by the Medical Research Council Scottish Clinical Pharmacology and Pathology Programme, The Royal College of Surgeons of Edinburgh Robertson’s Trust and The Melville Trust for the Care and Cure of Cancer.
Harrison, David J. +3 more
core +1 more source
Basic & Clinical Pharmacology & Toxicology, 2018 Pregnane X receptor (PXR), constitutive androstane receptor (CAR), aryl hydrocarbon receptor (AHR) and peroxisome proliferator-activated receptor α (PPARα) are ligand-activated transcription factors that regulate expression of many xenobiotic ...
J. Hakkola +5 more
semanticscholar +1 more source
Basic &Clinical Pharmacology &Toxicology, Volume 137, Issue 2, August 2025.Metabolic syndrome (MetS) is a combination of several factors, which lead to a higher risk of cardiovascular and other diseases. To study MetS, its mechanisms and means to alleviate complications associated with it, there is a demand for suitable animal models and their strains.
Jan Soukop +9 more
wiley +1 more source
THE CONCISE GUIDE TO PHARMACOLOGY 2017/18:Nuclear hormone receptors [PDF]
, 2017 The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and ...
, +11 more
core +5 more sources
American Journal of Industrial Medicine, Volume 68, Issue 7, Page 588-597, July 2025.ABSTRACT Objectives Nonalcoholic fatty liver disease (NAFLD) is a major public health problem and the most common chronic liver disease today. In Korea, the prevalence and incidence of NAFLD are currently very high, causing a serious social burden. Perfluoroalkyl substances (PFAS) have been consistently implicated as a potential cause of NAFLD, but ...
Jisuk Yun, Young‐Sun Min
wiley +1 more source
Cytochrome P450 2B6 (CYP2B6) and constitutive androstane receptor (CAR) polymorphisms are associated with early discontinuation of efavirenz-containing regimens [PDF]
, 2017 Objectives Cytochrome P450 2B6 (CYP2B6) is responsible for the metabolic clearance of efavirenz and single nucleotide polymorphisms (SNPs) in the CYP2B6 gene are associated with efavirenz pharmacokinetics. Since the constitutive androstane receptor (CAR)
Back, David J. +59 more
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