Results 31 to 40 of about 45,599 (229)

Dimorphic metabolic and endocrine disorders in mice lacking the constitutive androstane receptor. [PDF]

Sci Rep, 2019
Metabolic diseases such as obesity, type II diabetes and hepatic steatosis are a public health concern in developed countries. The metabolic risk is gender‐dependent.
Lukowicz C, Ellero-Simatos S, Régnier M, Oliviero F, Lasserre F, Polizzi A, Montagner A, Smati S, Boudou F, Lenfant F, Guzylack-Pirou L, Menard S, Barretto S, Fougerat A, Lippi Y, Naylies C, Bertrand-Michel J, Belgnaoui AA, Theodorou V, Marchi N, Gourdy P, Gamet-Payrastre L, Loiseau N, Guillou H, Mselli-Lakhal L.   +24 more
europepmc   +2 more sources

Constitutive androstane receptor (CAR) functions as a tumor suppressor via regulating stemness in liver cancer [PDF]

Scientific Reports
Constitutive androstane receptor (CAR) is a xenosensor that is almost exclusively expressed in the liver. Studies in rodents suggest an oncogenic role for CAR in liver cancer, but its role in human liver cancer is unclear.
Sarah Da Won Bae, Romario Nguyen, Lawrence Yuen, Vincent Lam, Jacob George, Liang Qiao   +5 more
doaj   +2 more sources

DNA elements for constitutive androstane receptor- and pregnane X receptor-mediated regulation of bovine CYP3A28 gene.

PLoS ONE, 2019
The regulation of cytochrome P450 3A (CYP3A) enzymes is established in humans, but molecular mechanisms of its basal and xenobiotic-mediated regulation in cattle are still unknown.
Mery Giantin, Jenni Küblbeck, Vanessa Zancanella, Viktoria Prantner, Fabiana Sansonetti, Axel Schoeniger, Roberta Tolosi, Giorgia Guerra, Silvia Da Ros, Mauro Dacasto, Paavo Honkakoski   +10 more
doaj   +2 more sources

Transcriptomic analysis across liver diseases reveals disease-modulating activation of constitutive androstane receptor in cholestasis [PDF]

JHEP Reports, 2020
Background & Aims: Liver diseases are caused by many factors, such as genetics, nutrition, and viruses. Therefore, it is important to delineate transcriptomic changes that occur in various liver diseases.
Bhoomika Mathur, Waqar Arif, Megan E. Patton, Rahiman Faiyaz, Jian Liu, Jennifer Yeh, Sanjiv Harpavat, Kristina Schoonjans, Auinash Kalsotra, Antony M. Wheatley, Sayeepriyadarshini Anakk   +10 more
doaj   +2 more sources

Constitutive androstane receptor-responsive elements for mouse Cyp1a2 transcriptional activation induced by constitutive androstane receptor ligands.

Drug Metabolism and Pharmacokinetics, 2022
The mouse cytochrome P450 1A2 (Cyp1a2) gene is one of the constitutive androstane receptor (CAR, NR1I3) activator-inducible genes, and the regions involved in induction were examined herein. A reporter gene assay indicated the involvement of the -0.2-kb region in the induction of transcriptional activation by the mouse CAR agonist ligand 1,4-bis-[2-(3 ...
Yuki Kawasaki, N. Nemoto, T. Sakuma
semanticscholar   +3 more sources

An optimized protocol with a stepwise approach to identify specific nuclear receptor ligands from cultured mammalian cells

STAR Protocols, 2021
Summary: Here, we describe an optimized protocol to identify specific nuclear receptor ligands. First, to rule out any compound interference with luciferase activity per se, we describe an in vitro assay assessing potential inhibition or activation of ...
Alexandre Berthier, Bart Staels, Philippe Lefebvre   +2 more
doaj   +1 more source

Constitutive androstane receptor (CAR) mediates pyrene‐induced inflammatory responses in mouse liver, with increased serum amyloid A proteins and Th17 cells

British Journal of Pharmacology, 2022
The constitutive androstane receptor (CAR), a known xenobiotic sensor, plays an important role in drug metabolism by regulating numerous genes. The polycyclic aromatic hydrocarbon pyrene, an environmental pollutant, is a CAR activator and induces mouse ...
Zhe Shi, Xue Li, Yu-Man Zhang, Yi‐Yao Zhou, Xiu-Feng Gan, Qiao‐Ying Fan, Chen-Qing He, Tong Shi, Shu-Yun Zhang   +8 more
semanticscholar   +1 more source

Critical evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR)

Critical Reviews in Toxicology, 2021
Many nongenotoxic chemicals have been shown to produce liver tumors in mice and/or rats by a mode of action (MOA) involving activation of the constitutive androstane receptor (CAR).
Tomoya Yamada, S. Cohen, B. Lake
semanticscholar   +1 more source

Canvass: a crowd-sourced, natural-product screening library for exploring biological space [PDF]

, 2018
NCATS thanks Dingyin Tao for assistance with compound characterization. This research was supported by the Intramural Research Program of the National Center for Advancing Translational Sciences, National Institutes of Health (NIH). R.B.A.
Andrade, Rodrigo B., Bougie, Danielle, Boxer, Matthew B., Brimacombe, Kyle R., Brown, Lauren E., Brown, M Kevin, Burns, Noah Z., Cha, Jin K., Cheff, Dorian M., Cheng, Ken, Clardy, Jon, Clement, Jason A., Coussens, Nathan P., Crooks, Peter A., Cuny, Gregory D., Dillon, Christopher, Dorjsuren, Dorjbal, Eastman, Richard T., Ganor, Jake, Garg, Neil K., Goess, Brian C., Grossman, Robert B., Guha, Rajarshi, Hall, Matthew D., Henderson, Mark J., Huang, Ruili, Hughes, Chambers C., Iannotti, Michael J., Inglese, James, Itkin, Zina, Jadhav, Ajit, Johnston, Jeffrey N., Joullie, Madeleine M., Karavadhi, Surendra, Kearney, Sara E., Kinghorn, A. Douglas, Kingston, David G. I., Klumpp-Thomas, Carleen, Krische, Michael J., Kwon, Ohyun, Lee, Tobie D., Lynch, Caitlin, Maimone, Thomas J., Majumdar, Susruta, Maloney, Katherine N., Mevers, Emily E., Michael, Sam, Mohamed, Enas, Moreno, Jesus, Morrill, Lucas A., Murphy, Brian T., Nagorny, Pavel, Olson, David E., Overman, Larry E., Picazo, Elias, Porco, John A., Ren, Tianjing, Rivas, Fatima, Rohde, Jason M., Ross, Samir A., Roth, Jacob S., Sakamuru, Srilatha, Sarpong, Richmond, Sharma, Indrajeet, Shaw, Jared T., Shen, Ben, Shen, Min, Shi, Wei, Shinn, Paul, Simeonov, Anton, Snyder, John K., Stephenson, Corey R. J., Sun, Wei, Susick, Robert B., Tan, Derek S., Tang, Yi, Taylor, Richard E., Thomson, Regan J., Titus, Steven A., Verano, Alyssa L., Vosburg, David A., Wan, Kanny K., Wu, Jimmy, Wuest, William M., Xia, Menghang, Xu, Zhengren, Yasgar, Adam, Zahoranszky-Kohalmi, Gergely, Zakarian, Armen, Zhang, Ya-Qin, Zhang, Yufeng, Zhao, Jinghua, Zhao, Tongan, Zheng, Wei, Zuo, Zhong   +94 more
core   +4 more sources

Nuclear receptor CAR represses TNFα-induced cell death by interacting with the anti-apoptotic GADD45B [PDF]

, 2010
Background: Phenobarbital (PB) is the most well-known among numerous non-genotoxic carcinogens that cause the development of hepatocellular carcinoma (HCC). PB activates nuclear xenobiotic receptor Constitutive Active/Androstane Receptor (CAR; NR1I3) and
Binfeng Lu, Masahiko Negishi, Richard A. Flavell, Rick Moore, Ulrich Zanger, Yukio Yamamoto   +5 more
core   +10 more sources