Results 51 to 60 of about 42,112 (221)

AhR, PXR and CAR: From Xenobiotic Receptors to Metabolic Sensors

Cells, 2023
Traditionally, xenobiotic receptors are known for their role in chemical sensing and detoxification, as receptor activation regulates the expression of various key enzymes and receptors.
Leonida Rakateli, Rosanna Huchzermeier, Emiel P. C. van der Vorst   +2 more
doaj   +1 more source

Small-molecule modulators of the constitutive androstane receptor [PDF]

Expert Opinion on Drug Metabolism & Toxicology, 2015
The constitutive androstane receptor (CAR) induces drug-metabolizing enzymes for xenobiotic metabolism.This review covers recent advances in elucidating the biological functions of CAR and its modulation by a growing number of agonists and inhibitors.Extrapolation of animal CAR function to that of humans should be carefully scrutinized, particularly ...
Milu T, Cherian, Sergio C, Chai, Taosheng, Chen   +2 more
openaire   +2 more sources

Modulation of Xenobiotic Receptors by Steroids

Molecules, 2013
Nuclear receptors (NRs) are ligand-activated transcription factors that regulate the expression of their target genes. NRs play important roles in many human diseases, including metabolic diseases and cancer, and are therefore a key class of therapeutic ...
Delira Robbins, Monimoy Banerjee, Taosheng Chen   +2 more
doaj   +1 more source

Dietary Flavonoids Activate the Constitutive Androstane Receptor (CAR) [PDF]

Journal of Agricultural and Food Chemistry, 2010
The constitutive androstane receptor (CAR) is known as a xeno-sensor that regulates genes involved in xenobiotic excretion and energy metabolism. This study tested a variety of polyphenols for their ability to modulate CAR activity. HepG2 cells were transfected with a CAR expression plasmid and a reporter plasmid containing the human CYP2B6 regulatory ...
Ruiquing, Yao, Akihito, Yasuoka, Asuka, Kamei, Yoshinori, Kitagawa, Norifumi, Tateishi, Nobuo, Tsuruoka, Yoshionobu, Kiso, Tatsuya, Sueyoshi, Masahiko, Negishi, Takumi, Misaka, Keiko, Abe   +10 more
openaire   +2 more sources

Structural and functional similarity of amphibian constitutive androstane receptor with mammalian pregnane X receptor.

PLoS ONE, 2014
The nuclear receptors and xenosensors constitutive androstane receptor (CAR, NR1I3) and pregnane X receptor (PXR, NR1I2) induce the expression of xenobiotic metabolizing enzymes and transporters, which also affects various endobiotics.
Marianne Mathäs, Christian Nusshag, Oliver Burk, Ute Gödtel-Armbrust, Holger Herlyn, Leszek Wojnowski, Björn Windshügel   +6 more
doaj   +1 more source

The Environmental Estrogen, Nonylphenol, Activates the Constitutive Androstane Receptor [PDF]

Toxicological Sciences, 2007
Nonylphenol (NP) and its parent compounds, the nonylphenol ethoxylates are some of the most prevalent chemicals found in U.S. waterways. NP is also resistant to biodegradation and is a known environmental estrogen, which makes NP a chemical of concern.
Juan P, Hernandez, Wendong, Huang, Laura M, Chapman, Steven, Chua, David D, Moore, William S, Baldwin   +5 more
openaire   +2 more sources

Regulation of CYP3A genes by glucocorticoids in human lung cells [v2; ref status: indexed, http://f1000r.es/1z6]

F1000Research, 2013
Inhaled glucocorticoids are the first-line treatment for patients with persistent asthma.  However, approximately thirty percent of patients exhibit glucocorticoid insensitivity, which may involve excess metabolic clearance of the glucocorticoids by ...
Jessica K Roberts, Chad D Moore, Erin G Romero, Robert M Ward, Garold S Yost, Christopher A Reilly   +5 more
doaj   +1 more source

Alternatively spliced isoforms of the human constitutive androstane receptor [PDF]

Nucleic Acids Research, 2003
The nuclear receptor CAR (NR1I3) regulates transcription of genes encoding xenobiotic- and steroid-metabolizing enzymes. Regulatory processes that are mediated by CAR are modulated by a structurally diverse array of chemicals including common pharmaceutical and environmental agents.
Scott S, Auerbach, Richard, Ramsden, Matthew A, Stoner, Christophe, Verlinde, Christopher, Hassett, Curtis J, Omiecinski   +5 more
openaire   +2 more sources

Regulation of CYP3A genes by glucocorticoids in human lung cells [v1; ref status: indexed, http://f1000r.es/1f9]

F1000Research, 2013
Inhaled glucocorticoids are the first-line treatment for patients with persistent asthma.  However, approximately thirty percent of patients exhibit glucocorticoid insensitivity, which may involve excess metabolic clearance of the glucocorticoids by ...
Jessica K Roberts, Chad D Moore, Erin G Romero, Robert M Ward, Garold S Yost, Christopher A Reilly   +5 more
doaj   +1 more source

Dehydroepiandrosterone Induces Human CYP2B6 through the Constitutive Androstane Receptor [PDF]

Drug Metabolism and Disposition, 2007
Dehydroepiandrosterone (DHEA), the major precursor of androgens and estrogens, has several beneficial effects on the immune system, on memory function, and in modulating the effects of diabetes, obesity, and chemical carcinogenesis. Treatment of rats with DHEA influences expression of cytochrome P450 (P450) genes, including peroxisome proliferator ...
Krisztina, Kohalmy, Viola, Tamási, László, Kóbori, Eniko, Sárváry, Jean-Marc, Pascussi, Pálma, Porrogi, Damjana, Rozman, Russell A, Prough, Urs A, Meyer, Katalin, Monostory   +9 more
openaire   +2 more sources