Results 51 to 60 of about 69,599 (292)

Constitutive androstane receptor induced-hepatomegaly and liver regeneration is partially via yes-associated protein activation. [PDF]

Acta Pharm Sin B, 2021
Gao Y, Fan S, Li H, Jiang Y, Yao X, Zhu S, Yang X, Wang R, Tian J, Gonzalez FJ, Huang M, Bi H.   +11 more
europepmc   +2 more sources

Constitutive androstane receptor (CAR) mediates pyrene‐induced inflammatory responses in mouse liver, with increased serum amyloid A proteins and Th17 cells

British Journal of Pharmacology, 2022
The constitutive androstane receptor (CAR), a known xenobiotic sensor, plays an important role in drug metabolism by regulating numerous genes. The polycyclic aromatic hydrocarbon pyrene, an environmental pollutant, is a CAR activator and induces mouse ...
Zhe Shi, Xue Li, Yu-Man Zhang, Yi‐Yao Zhou, Xiu-Feng Gan, Qiao‐Ying Fan, Chen-Qing He, Tong Shi, Shu-Yun Zhang   +8 more
semanticscholar   +1 more source

Activation of the Constitutive Androstane Receptor by Monophthalates [PDF]

Chemical Research in Toxicology, 2016
Humans in industrialized areas are continuously exposed to phthalate plasticizers, prompting concerns of their potential toxicities. Previous studies from our laboratory and others have shown that various phthalates activate several mammalian nuclear receptors, in particular the constitutive androstane receptor (CAR), the pregnane X receptor (PXR), and
Denise M. Coslo, Elizabeth M. Laurenzana, Anthony M. Roman, Curtis J. Omiecinski, M. Veronica Vigilar   +4 more
openaire   +3 more sources

Critical evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR)

Critical Reviews in Toxicology, 2021
Many nongenotoxic chemicals have been shown to produce liver tumors in mice and/or rats by a mode of action (MOA) involving activation of the constitutive androstane receptor (CAR).
Tomoya Yamada, S. Cohen, B. Lake
semanticscholar   +1 more source

Signaling control of the constitutive androstane receptor (CAR) [PDF]

Protein & Cell, 2014
The constitutive androstane receptor (CAR, NR1I3) plays a crucial role in the regulation of drug metabolism, energy homeostasis, and cancer development through modulating the transcription of its numerous target genes. Different from prototypical nuclear receptors, CAR can be activated by either direct ligand binding or ligand-independent (indirect ...
Hui Yang, Hongbing Wang
openaire   +3 more sources

AhR, PXR and CAR: From Xenobiotic Receptors to Metabolic Sensors

Cells, 2023
Traditionally, xenobiotic receptors are known for their role in chemical sensing and detoxification, as receptor activation regulates the expression of various key enzymes and receptors.
Leonida Rakateli, Rosanna Huchzermeier, Emiel P. C. van der Vorst   +2 more
doaj   +1 more source

Small-molecule modulators of the constitutive androstane receptor [PDF]

Expert Opinion on Drug Metabolism & Toxicology, 2015
The constitutive androstane receptor (CAR) induces drug-metabolizing enzymes for xenobiotic metabolism.This review covers recent advances in elucidating the biological functions of CAR and its modulation by a growing number of agonists and inhibitors.Extrapolation of animal CAR function to that of humans should be carefully scrutinized, particularly ...
Milu T. Cherian, Taosheng Chen, Sergio C. Chai   +2 more
openaire   +2 more sources

Constitutive androstane receptor: A tumor suppressor and a biomarker for favorable prognosis of liver diseases [PDF]

Genes and Diseases
Sarah Da Won Bae, Romario Nguyen, Lawrence Yuen, Vincent Lam, Jacob George, Liang Qiao   +5 more
doaj   +2 more sources

Modulation of Xenobiotic Receptors by Steroids

Molecules, 2013
Nuclear receptors (NRs) are ligand-activated transcription factors that regulate the expression of their target genes. NRs play important roles in many human diseases, including metabolic diseases and cancer, and are therefore a key class of therapeutic ...
Delira Robbins, Monimoy Banerjee, Taosheng Chen   +2 more
doaj   +1 more source

The SARS-CoV-2 Spike Protein is vulnerable to moderate electric fields [PDF]

, 2021
Most of the ongoing projects aimed at the development of specific therapies and vaccines against COVID-19 use the SARS-CoV-2 spike (S) protein as the main target [1-3]. The binding of the spike protein with the ACE2 receptor (ACE2) of the host cell constitutes the first and key step for virus entry. During this process, the receptor binding domain (RBD)
arxiv   +1 more source