Results 61 to 70 of about 45,599 (229)

Xenobiotic CAR activators induce Dlk1-Dio3 locus non-coding RNA expression in mouse liver [PDF]

, 2017
Predicting the impact of human exposure to chemicals such as pharmaceuticals and agrochemicals requires the development of reliable and predictive biomarkers suitable for the detection of early events potentially leading to adverse outcomes.
Dubost, Valérie, Dumotier, Bérengère, Elcombe, Cliff R., Ellinger-Ziegelbauer, Heidrun, Fekete, Alexander, Glogovac, Milica, Henderson, Colin J., Huang, Jeffrey T. J., MacLeod, A. Kenneth, Moggs, Jonathan G., Moreno , Rita, Moulin, Pierre, Pouché , Lucie, Römer, Michael, Schwarz, Michael, Stiehl, Daniel Philipp, Terranova, Rémi, Vitobello, Antonio, Westphal, Magdalena, Wolf, C. Roland, Zell, Andreas   +20 more
core   +2 more sources

A brief history of the discovery of PXR and CAR as xenobiotic receptors

Acta Pharmaceutica Sinica B, 2016
The nuclear receptors pregnane X receptor (PXR) and constitutive androstane receptor (CAR) were cloned and/or established as xenobiotic receptors in 1998.
Jiong Yan, Wen Xie
doaj   +1 more source

A Targeted in Vivo SILAC Approach for Quantification of Drug Metabolism Enzymes:Regulation by the Constitutive Androstane Receptor [PDF]

, 2013
The modulation of drug metabolism enzyme (DME) expression by therapeutic agents is a central mechanism of drug-drug interaction and should be assessed as early as possible in preclinical drug development.
Henderson, Colin J., Huang, Jeffrey T.-J., Macleod, A. Kenneth, Riches, Zoe, Wolf, C. Roland, Zang, Tuo   +5 more
core   +5 more sources

Activation of Constitutive Androstane Receptor Prevents Cholesterol Gallstone Formation [PDF]

The American Journal of Pathology, 2017
Cholesterol gallstone disease (CGD) is one of the most common gastrointestinal diseases. Lithogenic hepatic bile secretion precedes the formation of cholesterol gallstones. Constitutive androstane receptor (CAR), a member of nuclear family, plays an important role in cholesterol and bile acid metabolism. To examine whether activation of CAR can prevent
Shihai, Cheng, Min, Zou, Qinhui, Liu, Jiangying, Kuang, Jing, Shen, Shiyun, Pu, Lei, Chen, Hong, Li, Tong, Wu, Rui, Li, Yanping, Li, Wei, Jiang, Zhiyong, Zhang, Jinhan, He   +13 more
openaire   +2 more sources

Triclocarban mediates induction of xenobiotic metabolism through activation of the constitutive androstane receptor and the estrogen receptor alpha.

PLoS ONE, 2012
Triclocarban (3,4,4'-trichlorocarbanilide, TCC) is used as a broad-based antimicrobial agent that is commonly added to personal hygiene products. Because of its extensive use in the health care industry and resistance to degradation in sewage treatment ...
Mei-Fei Yueh, Tao Li, Ronald M Evans, Bruce Hammock, Robert H Tukey   +4 more
doaj   +1 more source

Cross-species comparison of CAR-mediated procarcinogenic key events in a 3D liver microtissue model [PDF]

, 2019
Characterisation of the mode of action (MOA) of constitutive androstane receptor (CAR)-mediated rodent liver tumours involves measurement 5 key events including activation of the CAR receptor, altered gene expression, hepatocellular proliferation, clonal
Ball, Graeme, Beaumont, Bobby, Cowie, David, Currie, Richard, McInnes, Liz, Peffer, Rich, Plummer, Simon, Wallace, Stephanie, Wright, Jayne   +8 more
core   +2 more sources

Stereoisomerization of human constitutive androstane receptor agonist CITCO

Tetrahedron, 2021
Abstract CITCO (6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde-O-(3,4-dichlorobenzyl) oxime) is a widely used agonist of the human constitutive androstane receptor (hCAR), a key hepatic xenobiotic sensor protein with emerging therapeutic indications. To address the insufficient stability of CITCO, which limits its therapeutic potential,
Benjamin Diethelm-Varela, Anmol Kumar, Caitlin Lynch, Gregory H. Imler, Jeffrey R. Deschamps, Yue Li, Menghang Xia, Alexander D. MacKerell, Fengtian Xue   +8 more
openaire   +2 more sources

Phenobarbital-mediated tumor promotion in transgenic mice with humanized CAR and PXR [PDF]

, 2014
The nuclear receptors CAR (constitutive androstane receptor) and possibly PXR (pregnane X receptor) mediate the hepatic effects of phenobarbital (PB) and similar-acting compounds.
Braeuning, Albert, Brown, Susan, Gavrilov, Alina, Henderson, Colin J, Schwarz, Michael, Wolf, C Roland   +5 more
core   +2 more sources

The Concise Guide to PHARMACOLOGY 2015/16:Nuclear hormone receptors [PDF]

, 2015
The Concise Guide to PHARMACOLOGY 2015/16 provides concise overviews of the key properties of over 1750 human drug targets with their pharmacology, plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org),
Aldrich, R, Alexander, SPH, Attali, B, Back, M, Barnes, NM, Bathgate, R, Beart, PM, Becirovic, E, Benson, HE, Biel, M, Birdsall, NJ, Boison, D, Brauner-Osborne, H, Broeer, S, Bryant, C, Burnstock, G, Burris, T, Cain, D, Calo, G, Chan, SL, Chandy, KG, Chiang, N, Christakos, S, Christopoulos, A, Chun, JJ, Chung, J-J, Cidlowski, JA, Clapham, DE, Connor, MA, Coons, L, Cox, HM, Dautzenberg, FM, Davies, JA, Dent, G, Douglas, SD, Dubocovich, ML, Edwards, DP, Faccenda, E, Farndale, R, Fong, TM, Forrest, D, Fowler, CJ, Fuller, P, Gainetdinov, RR, Gershengorn, MA, Goldin, A, Goldstein, SAN, Grimm, SL, Grissmer, S, Gundlach, AL, Hagenbuch, B, Hammond, JR, Hancox, JC, Hartig, S, Hauger, RL, Hay, DL, Hebert, T, Hollenberg, AN, Holliday, ND, Hoyer, D, Ijzerman, AP, Inui, KI, Ishii, S, Jacobson, KA, Jan, LY, Jarvis, GE, Jensen, R, Jetten, A, Jockers, R, Kaczmarek, LK, Kanai, Y, Kang, HS, Karnik, S, Kelly, E, Kerr, ID, Korach, KS, Lange, CA, Larhammar, D, Leeb-Lundberg, F, Leurs, R, Lolait, SJ, Macewan, D, Maguire, JJ, Marrion, N, May, JM, Mazella, J, McArdle, CA, McDonnell, DP, Michel, MC, Miller, LJ, Mitolo, V, Monie, T, Monk, PN, Mouillac, B, Murphy, PM, Nahon, J-L, Nerbonne, J, Nichols, CG, Norel, X, Oakley, R, Offermanns, S, Palmer, LG, Panaro, MA, Pawson, AJ, Perez-Reyes, E, Pertwee, RG, Peters, JA, Pike, JW, Pin, JP, Pintor, S, Plant, LD, Poyner, DR, Prossnitz, ER, Pyne, S, Ren, D, Richer, JK, Rondard, P, Ross, RA, Sackin, H, Safi, R, Sanguinetti, MC, Sartorius, CA, Segaloff, DL, Sharman, JL, Sladek, FM, Southan, C, Stewart, G, Stoddart, LA, Striessnig, J, Summers, RJ, Takeda, Y, Tetel, M, Toll, L, Trimmer, JS, Tsai, M-J, Tsai, SY, Tucker, S, Usdin, TB, Vilargada, J-P, Vore, M, Ward, DT, Waxman, SG, Webb, P, Wei, AD, Weigel, N, Willars, GB, Winrow, C, Wong, SS, Wulff, H, Ye, RD, Young, M, Zajac, J-M   +151 more
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Pharmacokinetic Herb-Drug Interactions: Insight into Mechanisms and Consequences [PDF]

, 2015
Herbal medicines are currently in high demand, and their popularity is steadily increasing. Because of their perceived effectiveness, fewer side effects and relatively low cost, they are being used for the management of numerous medical conditions ...
Horie, Toshiharu, Oga, Enoche Florence, Sekine, Shuichi, Shitara, Yoshihisa   +3 more
core   +1 more source