Results 61 to 70 of about 69,599 (292)
The Environmental Estrogen, Nonylphenol, Activates the Constitutive Androstane Receptor [PDF]
Toxicological Sciences, 2007 Nonylphenol (NP) and its parent compounds, the nonylphenol ethoxylates are some of the most prevalent chemicals found in U.S. waterways. NP is also resistant to biodegradation and is a known environmental estrogen, which makes NP a chemical of concern.
Juan P. Hernandez +5 more
openaire +3 more sources
PLoS ONE, 2014 The nuclear receptors and xenosensors constitutive androstane receptor (CAR, NR1I3) and pregnane X receptor (PXR, NR1I2) induce the expression of xenobiotic metabolizing enzymes and transporters, which also affects various endobiotics.
Marianne Mathäs +6 more
doaj +1 more source
F1000Research, 2013 Inhaled glucocorticoids are the first-line treatment for patients with persistent asthma. However, approximately thirty percent of patients exhibit glucocorticoid insensitivity, which may involve excess metabolic clearance of the glucocorticoids by ...
Jessica K Roberts +5 more
doaj +1 more source
Activation of Constitutive Androstane Receptor Ameliorates Renal Ischemia-Reperfusion–Induced Kidney and Liver Injury [PDF]
Molecular Pharmacology, 2018 You‐Jin Choi +9 more
openalex +2 more sources
Alternatively spliced isoforms of the human constitutive androstane receptor [PDF]
Nucleic Acids Research, 2003 The nuclear receptor CAR (NR1I3) regulates transcription of genes encoding xenobiotic- and steroid-metabolizing enzymes. Regulatory processes that are mediated by CAR are modulated by a structurally diverse array of chemicals including common pharmaceutical and environmental agents.
Christophe L. M. J. Verlinde +5 more
openaire +3 more sources
F1000Research, 2013 Inhaled glucocorticoids are the first-line treatment for patients with persistent asthma. However, approximately thirty percent of patients exhibit glucocorticoid insensitivity, which may involve excess metabolic clearance of the glucocorticoids by ...
Jessica K Roberts +5 more
doaj +1 more source
Dual action of oestrogens on the mouse constitutive androstane receptor [PDF]
Biochemical Journal, 2003 mCAR (mouse constitutive androstane receptor; NR1I3) controls the expression of cytochrome P450 as well as other enzymes involved in drug and steroid metabolism. The high basal activity of mCAR can be modulated by inhibitory steroids related to androstenol and by activating xenobiotic chemicals such as 1,4-bis-[2-(3,5-dichloropyridyloxy)]benzene and ...
Hinfan Chung +7 more
openaire +3 more sources
A brief history of the discovery of PXR and CAR as xenobiotic receptors
Acta Pharmaceutica Sinica B, 2016 The nuclear receptors pregnane X receptor (PXR) and constitutive androstane receptor (CAR) were cloned and/or established as xenobiotic receptors in 1998.
Jiong Yan, Wen Xie
doaj +1 more source
Persisting fetal clonotypes influence the structure and overlap of adult human T cell receptor repertoires [PDF]
PLoS Comput Biol 13(7): e1005572 (2017), 2016 The diversity of T-cell receptors recognizing foreign pathogens is generated through a highly stochastic recombination process, making the independent production of the same sequence rare. Yet unrelated individuals do share receptors, which together constitute a "public" repertoire of abundant clonotypes.
arxiv +1 more source
Xenobiotic CAR activators induce Dlk1-Dio3 locus non-coding RNA expression in mouse liver [PDF]
, 2017 Predicting the impact of human exposure to chemicals such as pharmaceuticals and agrochemicals requires the development of reliable and predictive biomarkers suitable for the detection of early events potentially leading to adverse outcomes.
Dubost, Valérie +20 more
core +2 more sources