Results 81 to 90 of about 45,599 (229)

Comparison of the hepatic effects of phenobarbital in chimeric mice containing either rat or human hepatocytes with humanized constitutive androstane receptor (CAR) and pregnane X receptor (PXR) mice (hCAR/hPXR mice).

Toxicological Sciences, 2020
Using a chimeric mouse humanized liver model, we provided evidence that human hepatocytes are refractory to the mitogenic effects of rodent constitutive androstane receptor (CAR) activators.
Tomoya Yamada, A. Ohara, Naoya Ozawa, Keiko Maeda, M. Kondo, Y. Okuda, J. Abe, S. Cohen, B. Lake   +8 more
semanticscholar   +1 more source

Nuclear receptors constitutive androstane receptor and pregnane X receptor ameliorate cholestatic liver injury [PDF]

Proceedings of the National Academy of Sciences, 2005
Cholestasis is associated with accumulation of bile acids and lipids, and liver injury. The constitutive androstane receptor (CAR) and pregnane X receptor (PXR) are xenobiotic nuclear receptors that coordinate protective hepatic responses to potentially toxic stimuli, including bile acids. We investigated the role of these receptors in the
Catherine A M, Stedman, Christopher, Liddle, Sally A, Coulter, Junichiro, Sonoda, Jacqueline G A, Alvarez, David D, Moore, Ronald M, Evans, Michael, Downes   +7 more
openaire   +2 more sources

The ALS‐associated E425K mutation uncouples DNAJC7 from the Hsp70 chaperone cycle

The FEBS Journal, EarlyView.
DNAJC7 is a J‐domain protein that plays a key role in protein quality control by regulating Hsp70 activity and preventing protein aggregation. We find that the ALS‐associated E425K mutation in DNAJC7 disrupts productive interaction and activation of Hsp70, thereby blocking the transfer and refolding of client proteins such as TDP‐43.
Bar Elmaleh, Ofrah Faust, Rina Rosenzweig   +2 more
wiley   +1 more source

Transactivation Assays to Assess Canine and Rodent Pregnane X Receptor (PXR) and Constitutive Androstane Receptor (CAR) Activation. [PDF]

PLoS ONE, 2016
The pregnane X receptor (PXR/SXR, NR1I2) and constitutive androstane receptor (CAR, NR1I3) are nuclear receptors (NRs) involved in the regulation of many genes including cytochrome P450 enzymes (CYPs) and transporters important in metabolism and uptake ...
Marija Pinne, Elsa Ponce, Judy L Raucy
doaj   +1 more source

Liver transcriptome analysis of Atlantic cod (Gadus morhua) exposed to PCB 153 indicates effects on cell cycle regulation and lipid metabolism [PDF]

, 2014
Background: Polychlorinated biphenyls (PCBs) are persistent organic pollutants (POPs) with harmful effects in animals and humans. Although PCB 153 is one of the most abundant among PCBs detected in animal tissues, its mechanism of toxicity is not well ...
Anders Goksøyr, Christer Hogstrand, Fekadu Yadetie, Marta Eide, Odd Karlsen   +4 more
core   +1 more source

Metabolic Effects of a Chronic Dietary Exposure to a Low-Dose Pesticide Cocktail in Mice: Sexual Dimorphism and Role of the Constitutive Androstane Receptor

Environmental Health Perspectives, 2018
Background: Epidemiological evidence suggests a link between pesticide exposure and the development of metabolic diseases. However, most experimental studies have evaluated the metabolic effects of pesticides using individual molecules, often at ...
Céline Lukowicz, S. Ellero-Simatos, Marion Régnier, Arnaud Polizzi, F. Lasserre, A. Montagner, Y. Lippi, E. Jamin, Jean-François Martin, C. Naylies, C. Canlet, L. Debrauwer, J. Bertrand-Michel, T. al Saati, V. Théodorou, N. Loiseau, L. Mselli-Lakhal, H. Guillou, L. Gamet-Payrastre   +18 more
semanticscholar   +1 more source

A review of xenobiotic membrane transporter expression within the human placenta: Lessons gained from primary tissue and in vitro methodologies

The Journal of Physiology, EarlyView.
Abstract figure legend A summary of the current knowledge around membrane transporter expression in the most widely used in vitro models of human trophoblasts, including primary placental tissue, cancer cell lines and trophoblast stem cells, as well as the techniques to attempt to mimic the human placenta in vivo.
Rhiannon Pass, Kathryn Wolton, Amanda N. Sferruzzi‐Perri   +2 more
wiley   +1 more source

Interaction of PER2 with the constitutive androstane receptor possibly links circadian rhythms to metabolism

Acta Chimica Slovenica, 2017
Period 2 (PER2) is an important factor in daily oscillations called circadian rhythms, which are emerging as one of the most important regulatory networks, responsible for homeostasis and transcriptional regulation of a number of genes.
Tomaž Martini, Jurij Stojan, Damjana Rozman, Uršula Prosenc Zmrzljak   +3 more
doaj   +1 more source

High-throughput toxicogenomic screening of chemicals in the environment using metabolically competent hepatic cell cultures

npj Systems Biology and Applications, 2021
The ToxCast in vitro screening program has provided concentration-response bioactivity data across more than a thousand assay endpoints for thousands of chemicals found in our environment and commerce.
Jill A. Franzosa, Jessica A. Bonzo, John Jack, Nancy C. Baker, Parth Kothiya, Rafal P. Witek, Patrick Hurban, Stephen Siferd, Susan Hester, Imran Shah, Stephen S. Ferguson, Keith A. Houck, John F. Wambaugh   +12 more
doaj   +1 more source

Constitutive androstane receptor and pregnane X receptor cooperatively ameliorate DSS-induced colitis [PDF]

Digestive and Liver Disease, 2019
Nuclear receptor pregnane X receptor (PXR) was shown to be protective in case of dextran sulfate sodium (DSS)-induced colitis. Constitutive androstane receptor (CAR) belongs to the same nuclear receptor subfamily with PXR. The roles of both receptors in DSS-induced colitis were evaluated.Wild-type, Car-null, Pxr-null, and Car/Pxr-null mice were treated
Daisuke Uehara, Hiroki Tojima, Satoru Kakizaki, Yuichi Yamazaki, Norio Horiguchi, Daichi Takizawa, Ken Sato, Masanobu Yamada, Toshio Uraoka   +8 more
openaire   +2 more sources