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Isolation of Conventional Dendritic Cells from Mouse Lungs

2016
The lungs are in direct contact with the environment. Separated only by a thin layer of mucosa, the lung immune system is being exposed to dangers like pathogens, allergens, or pollutants. The lung dendritic cells form an elaborate network at the basolateral side of the epithelium and continuously sample antigens from the airway lumen. The conventional
Lianne, van de Laar   +2 more
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Glutamine Influences Type-1 Conventional Dendritic Cell Antitumor Immunity

Cancer Discovery, 2023
Abstract Glutamine supplementation improves antitumor immunity and reduces tumor growth by restoring cDC1 function.
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Tissue-Specific Diversity and Functions of Conventional Dendritic Cells

2017
Dendritic cells (DCs) are versatile controllers of immunity, which sense infection or tissue damage and, accordingly, initiate innate and adaptive effector responses. In recent years, it has become evident that DCs exist as an independent hematopoietic lineage comprising several developmentally distinct and functionally specialized subsets that are ...
Dalia, Pakalniškytė   +1 more
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In Vitro Generation of Human Cross-Presenting Type 1 Conventional Dendritic Cells (cDC1s) and Plasmacytoid Dendritic Cells (pDCs)

2023
Dendritic cells (DCs) represent one of the most important immune cell subsets in preventing the host from pathogen invasion by promoting both innate and adaptive immunity. Most research on human dendritic cells has focused on the easy-to-obtain dendritic cells derived in vitro from monocytes (MoDCs).
Luo, Xinlong   +3 more
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Differentially expressed microRNAs regulate plasmacytoid vs. conventional dendritic cell development

Molecular Immunology, 2010
microRNAs have emerged as a novel layer of regulation of cellular development and function, including cells of the immune system. microRNA expression profiles and function of several microRNAs have been elucidated in granulocyte macrophage colony-stimulating factor derived dendritic cells (GM-CSF DC). In this study we determined the microRNA expression
Harmjan, Kuipers   +2 more
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M-CSF: a novel plasmacytoid and conventional dendritic cell poietin

Blood, 2008
The critical importance of plasmacytoid dendritic cells (pDCs) in viral infection, autoimmunity, and tolerance has focused major attention on these cells that are rare in blood and immune organs of humans and mice. The recent development of an Flt-3 ligand (FL) culture system of bone marrow cells has led to the simple generation of large numbers of ...
Ben, Fancke   +3 more
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