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The conventional dendritic cell lineage is born
Nature Reviews Immunology, 2021Martin Guilliams and Charlotte Scott summarize some of the key studies that led to a refined dendritic cell nomenclature system based on ontogeny.
Martin Guilliams, Charlotte L. Scott
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Isolation of Conventional Murine Lung Dendritic Cell Subsets
2022In the lungs, immune cells make contact with different antigens every day. This requires an adequate immune response. Dendritic cells (DCs) form a dense network in the respiratory mucosa and continuously sample inhaled allergens. They play an important role in bridging innate and adaptive immunity.
Elisabeth, De Leeuw +3 more
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The Role of Type 1 Conventional Dendritic Cells in Cancer Immunity [PDF]
Trends in Cancer, 2018 Dendritic cells (DCs) are key orchestrators of immune responses. A specific DC subset, conventional type 1 DCs (cDC1s), has been recently associated with human cancer patient survival and, in preclinical models, is critical for the spontaneous rejection of immunogenic cancers and for the success of T cell-based immunotherapies.
Caetano Reis E Sousa, Jan Böttcher
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Merocytic dendritic cell: a new subset of conventional dendritic cells
The Journal of Immunology, 2019Abstract Conventional dendritic cells (cDC) are potent antigen-presenting cells that induce the activation of naïve T cells in response to pathogens. cDC activity is mediated primarily by two cDC subsets, namely cDC1 and cDC2, each bearing unique properties.
Cindy Audiger, Sylvie Lesage
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Isolation of Conventional Murine Lung Dendritic Cell Subsets
Current Protocols in Immunology, 2018AbstractThe lungs are continuously exposed to environmental threats, requiring an adequate and stringent immune response of a heterogeneous set of effector cells. Dendritic cells (DCs) form a dense network in the respiratory mucosa and act as the central regulators of the different components of this response, both sensing the nature of the threats and
Cédric, Bosteels +2 more
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Bacterial recognition by TLR7 in the lysosomes of conventional dendritic cells
Nature Immunology, 2009Little is known of how and where bacterial recognition triggers the induction of type I interferon. Whether the type of recognition receptor used in these responses is determined by the subcellular location of bacteria is not understood. Here we show that phagosomal bacteria such as group B streptococcus, but not cytosolic bacteria, potently induced ...
MANCUSO, Giuseppe +7 more
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The Generation of Plasmacytoid and Conventional Dendritic Cells with M-CSF
2009Mice lacking the ligand for Flt-3 (CD135) have a massive deficit of dendritic cells (DC) in all organs. This phenotype of FL (FL) knockout mice suggested that FL was the archetypal DC poietin in the steady state. However, FL knockout mice also have reduced numbers of common lymphoid progenitors (CLP) and common myeloid progenitors (CMP) so it is ...
Meredith, O'Keeffe +2 more
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Isolation of Conventional Dendritic Cells from Mouse Lungs
2016The lungs are in direct contact with the environment. Separated only by a thin layer of mucosa, the lung immune system is being exposed to dangers like pathogens, allergens, or pollutants. The lung dendritic cells form an elaborate network at the basolateral side of the epithelium and continuously sample antigens from the airway lumen. The conventional
Lianne, van de Laar +2 more
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Tissue-Specific Diversity and Functions of Conventional Dendritic Cells
2017Dendritic cells (DCs) are versatile controllers of immunity, which sense infection or tissue damage and, accordingly, initiate innate and adaptive effector responses. In recent years, it has become evident that DCs exist as an independent hematopoietic lineage comprising several developmentally distinct and functionally specialized subsets that are ...
Dalia, Pakalniškytė +1 more
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