Results 51 to 60 of about 5,838 (160)

Recognition of Complex Core‐Fucosylated N‐Glycans by a Mini Lectin

Angewandte Chemie, 2018
AbstractThe mini fungal lectin PhoSL was recombinantly produced and characterized. Despite a length of only 40 amino acids, PhoSL exclusively recognizes N‐glycans with α1,6‐linked fucose. Core fucosylation influences the intrinsic properties and bioactivities of mammalian N‐glycoproteins and its level is linked to various cancers. Thus, PhoSL serves as
Aurore Cabanettes, Lukas Perkams, Carolina Spies, Carlo Unverzagt, Annabelle Varrot   +4 more
openaire   +4 more sources

Post‐Translational Regulation of CD8+ T Cell Fate and Dysfunction in Tumor Immunity

Advanced Science, EarlyView.
This review delineates how post‐translational modifications (PTMs) function as a central regulatory interface governing CD8+ T cell activation, differentiation, persistence, and exhaustion in antitumor immunity. By integrating antigenic, metabolic, and microenvironmental cues, diverse PTM programs coordinate transcriptional and chromatin states that ...
Zihao Zhou, Xu Chen, Nina Li, Meiyan Zou, Yunfan Lin, Pei Lin, Weiyao Feng, Xinyuan Zhao, Li Cui   +8 more
wiley   +1 more source

Milk: Nature's Unique Nutritional Package

Animal Research and One Health, EarlyView.
ABSTRACT Plant‐based beverages that attempt to mimic milk are increasingly popular with consumers, but there are profound differences in nutritional composition and microstructure compared to milk. A structural nutrition approach is needed to understand the effect on digestibility of microstructures, bioaccessibility and bioavailability of components ...
David W. Everett, Caroline Thum
wiley   +1 more source

Gut microbiome‐derived metabolites show promise in cancer research and therapy

Interdisciplinary Medicine, EarlyView.
The metabolites produced by the gut microbiome, which are subject to regulation by multiple factors, play a pivotal role in the progression of various types of cancer. These metabolites not only function as potential biomarkers for the early detection and monitoring of tumor development, but also actively participate in cancer therapeutic processes ...
Kangjie Yang, Yifan Wang, Daolin Tang, Peilong Li, Lutao Du   +4 more
wiley   +1 more source

Mass-Selected Site-Specific Core-Fucosylation of Serum Proteins in Hepatocellular Carcinoma [PDF]

Journal of Proteome Research, 2015
A mass spectrometry-based methodology has been developed to screen for changes in site-specific core-fucosylation (CF) of serum proteins in early stage HCC with different etiologies. The methods involve depletion of high-abundance proteins, trypsin digestion of medium-to-low-abundance proteins into peptides, iTRAQ labeling, and Lens culinaris ...
Haidi, Yin, Zhijing, Tan, Jing, Wu, Jianhui, Zhu, Kerby A, Shedden, Jorge, Marrero, David M, Lubman   +6 more
openaire   +2 more sources

Distinctive domains and activity regulation of core fucosylation enzyme FUT8

Biochimica et Biophysica Acta (BBA) - General Subjects
Core fucose, a structure added to the reducing end N-acetylglucosamine of N-glycans, has been shown to regulate various physiological and pathological processes, including melanoma metastasis, exacerbation of chronic obstructive pulmonary disease, and severe outcomes in COVID-19.Recent research has shed light on regulation of the activity and ...
Seita, Tomida, Masamichi, Nagae, Yasuhiko, Kizuka   +2 more
  +5 more sources

Protein glycosylation in lung cancer from a mass spectrometry perspective

Mass Spectrometry Reviews, EarlyView.
Abstract Lung cancer is a severe disease for which better diagnostic and therapeutic approaches are urgently needed. Increasing evidence implies that aberrant protein glycosylation plays a crucial role in the pathogenesis and progression of lung cancer.
Mirjam Balbisi, Simon Sugár, Lilla Turiák   +2 more
wiley   +1 more source

A Strategy for Precise and Large Scale Identification of Core Fucosylated Glycoproteins [PDF]

Molecular & Cellular Proteomics, 2009
Core fucosylation (CF) patterns of some glycoproteins are more sensitive and specific than evaluation of their total respective protein levels for diagnosis of many diseases, such as cancers. Global profiling and quantitative characterization of CF glycoproteins may reveal potent biomarkers for clinical applications.
Wei, Jia, Zhuang, Lu, Yan, Fu, Hai-Peng, Wang, Le-Heng, Wang, Hao, Chi, Zuo-Fei, Yuan, Zhao-Bin, Zheng, Li-Na, Song, Huan-Huan, Han, Yi-Min, Liang, Jing-Lan, Wang, Yun, Cai, Yu-Kui, Zhang, Yu-Lin, Deng, Wan-Tao, Ying, Si-Min, He, Xiao-Hong, Qian   +17 more
openaire   +2 more sources

Mass spectrometry imaging of N‐linked glycans: Fundamentals and recent advances

Mass Spectrometry Reviews, EarlyView.
Abstract With implications in several medical conditions, N‐linked glycosylation is one of the most important posttranslation modifications present in all living organisms. Due to their nontemplate synthesis, glycan structures are extraordinarily complex and require multiple analytical techniques for complete structural elucidation.
Tana V. Palomino, David C. Muddiman
wiley   +1 more source

Quantitative glycoproteomics analysis identifies novel FUT8 targets and signaling networks critical for breast cancer cell invasiveness

Breast Cancer Research, 2022
Background We recently showed that fucosyltransferase 8 (FUT8)-mediated core fucosylation of transforming growth factor-β receptor enhances its signaling and promotes breast cancer invasion and metastasis.
Cheng-Fen Tu, Fu-An Li, Ling-Hui Li, Ruey-Bing Yang   +3 more
doaj   +1 more source