Results 91 to 100 of about 575,401 (181)

Human brain matters: Navigating the neuropathology of COVID‐19

Brain Pathology, EarlyView.
Severe COVID‐19 is associated with vascular dysregulation and chronic neuroinflammation, leading to axonal injury and neurodegeneration. In long COVID or PASC, persistent alterations in neuroimaging and biofluid biomarkers reflect ongoing neuronal damage and neuroinflammation, contributing to long‐term neurological symptoms including fatigue, cognitive
Juliana M. Nieuwland, Angelica Scaramuzza, Marianna Bugiani, Wilma D. J. van de Berg, Jinte Middeldorp   +4 more
wiley   +1 more source

Spreading depolarization, a pathophysiological mechanism of stroke and migraine aura

, 2012
Spreading depolarization is a mechanism of abrupt, massive ion translocation between intraneuronal and extracellular space that entails cytotoxic edema in the brain’s gray matter.
Clemens Reiffurth, Jens P Dreier, Denny Milakara, Ana I Oliveira-Ferreira, Johannes Woitzik, Maren KL Winkler   +5 more
core   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

sj-xlsx-3-cep-10.1177_03331024221146317 - Supplemental material for Genome-wide DNA methylation analysis in an antimigraine-treated preclinical model of cortical spreading depolarization

, 2023
Supplemental material, sj-xlsx-3-cep-10.1177_03331024221146317 for Genome-wide DNA methylation analysis in an antimigraine-treated preclinical model of cortical spreading depolarization by Marta Vila-Pueyo, Ester Cuenca-León, Ana C. Queirós, Marta Kulis,
José Ignacio Martín-Subero (8824076), Marta Kulis (122803), Bru Cormand (381015), Patricia Pozo-Rosich (4320316), Noèlia Fernàndez-Castillo (9563609), Ester Cuenca-León (381014), Ana C. Queirós (13013694), Marta Vila-Pueyo (14598793), Cèlia Sintas (14598796), Alfons Macaya (313600)   +9 more
core   +1 more source

Astrocytic connexin43 phosphorylation contributes to seizure susceptibility after mild traumatic brain injury

The FEBS Journal, EarlyView.
Astrocytic gap junctions formed by connexin43 (Cx43) help maintain brain homeostasis. After mild traumatic brain injury (TBI), total cortical Cx43 increases and redistributes toward a soluble, non‐junctional pool with elevated hemichannel activity and increased phosphorylation at serine 368 (pCx43S368).
Carmen Muñoz‐Ballester, Owen Leitzel, Samantha Golf, Chelsea M. Phillips, Michael J. Zeitz, Rahul Pandit, Elizabeth Wash, Jenna V. Donohue, Elizabeth A. Istre, James W. Smyth, Samy Lamouille, Stefanie Robel   +11 more
wiley   +1 more source

Deciphering Role of Endophytes in Plant Defences and Biotic Stress Resilience Across Families

Plant, Cell &Environment, EarlyView.
ABSTRACT Plant families generate distinct repertoires of specialised metabolites that govern their biotic interactions. Endophytes strengthen host plant defence mechanisms and tolerance to biotic challenges by upregulating metabolite biosynthesis, modifying precursor compounds into more potent forms, or by directly synthesising analogous defence ...
S. Aneeqa Noor, Kavita Verma, Nishu, Barkat Hussain, Vartika Mathur   +4 more
wiley   +1 more source

Geometry shapes propagation: assessing the presence and absence of cortical symmetries through a computational model of cortical spreading depression

Frontiers in Computational Neuroscience, 2016
Cortical spreading depression (CSD), a depolarization wave which originates in the visual cortex and travels towards the frontal lobe, has been suggested to be one neural correlate of aura migraine. To the date, little is known about the mechanisms which
Julia Maria Kroos, Ibai eDiez, Jesus M Cortes, Sebastiano eStramaglia, Luca eGerardo Giorda   +4 more
doaj   +1 more source

Combined Phosphorus and Potassium Starvation Upregulates Sodium Accumulation by HKT1;1 in Tomato Plants

Plant, Cell &Environment, EarlyView.
ABSTRACT Na+ can substitute K+ under K+ deficiency conditions, which is denominated as beneficial Na+. Despite its relevance at the physiological level and its interest in agriculture, the mechanisms allowing its uptake and use by plants remain unclear.
Jesús Amo, Adela Belchí, Elisa Jiménez‐Estévez, Adrián Yáñez, Maria José Asins, Andrés Belver, Vicente Martínez, Francisco Rubio, Manuel Nieves‐Cordones   +8 more
wiley   +1 more source

TMEM16A channel signalling microdomains in the regulation of vascular function

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic representation of TMEM16A channel signalling microdomains. Calcium influx or calcium release from the endoplasmic/sarcoplasmic reticulum (ER/SR) activates TMEM16A channels through interactions with regulatory proteins in vascular smooth muscle cells or endothelial cells. TMEM16A channel activation drives chloride efflux,
Fênix Araujo, Swapnil K. Sonkusare
wiley   +1 more source

Calcium‐activated chloride channels in pericytes and their role in regulating organ blood flow

The Journal of Physiology, EarlyView.
Abstract figure legend Pericytes are microvascular mural cells with diverse roles. Contractile pericytes directly regulate local perfusion, while non‐contractile pericytes coordinate upstream vascular contractility via propagating electrical signals.
Paolo Tammaro, Hikaru Hashitani
wiley   +1 more source