Results 71 to 80 of about 575,401 (181)
Triggered Calcium Lightning Programs Cochlear Development
Exploration, EarlyView.Summary: Before the onset of hearing, the developing inner ear generates spontaneous calcium signals that are thought to guide maturation. In this study, we discovered a rapid and widespread calcium flash—dubbed “Ca2+ lightning”—originating from supporting cells beneath the sensory hair cells, which triggers coordinated calcium waves across the entire ...
Qiang Ma +13 more
wiley +1 more source
Neurovascular coupling variation in cortical spreading depolarization may be a key to understanding the origin of neurologic injury. We imaged mice with widefield optical imaging through seizure induction, cortical spreading depolarization, and eventual ...
Humberto Mestre-Payne +4 more
core +1 more source
A hyperthermic seizure unleashes a surge of spreading depolarizations in Scn1a-deficient mice
JCI Insight, 2023 Spreading depolarization (SD) is a massive wave of cellular depolarization that slowly migrates across the brain gray matter. Cortical SD is frequently generated following brain injury, while less is understood about its potential contribution to genetic
Isamu Aiba, Yao Ning, Jeffrey L. Noebels
doaj +1 more source
Artificial structures for human‐machine interfaces with closed‐loop interaction
FlexMat, EarlyView.Artificial structures bridge sensing and feedback in closed‐loop human‐machine interfaces by providing geometry‐enabled mechanical and functional programmability. This review maps the role of artificial structures in diverse sensing modalities and feedback strategies, and illustrates their integration into closed‐loop interaction systems, highlighting ...
Taiqi Hu +4 more
wiley +1 more source
Active role of capillary pericytes during stimulation-induced activity and spreading depolarization
, 2018 Spreading depolarization is assumed to be the mechanism of migraine with aura, which is accompanied by an initial predominant hyperaemic response followed by persistent vasoconstriction.
Bodil Gesslein +13 more
core +1 more source
Laser &Photonics Reviews, EarlyView.Optical neuromodulation with IR light allows stimulation of the PNS without the need for physical contact with the target nerve or without requiring any genetic modification. The clinical translation of this technique will pave the way to the development of neural interfaces for restoring sensory feedback in individuals with limb amputation.
Federica Piccirillo +20 more
wiley +1 more source
Neuroprotection, EarlyView.This systematic review and meta‐analysis assessed the cytoprotective effects of neuromodulation in preclinical models of ischemic stroke. Pooled analyses showed that neuromodulation significantly reduced infarct volume and improved neurological outcomes.
Igor Caitano Salles +7 more
wiley +1 more source
Phytotherapy Research, EarlyView.Rh1 attenuates oxidative stress and mitochondrial dysfunction through SIRT1‐related signaling. ABSTRACT Alzheimer's disease (AD) remains a progressive neurodegenerative disorder with limited therapeutic options. Ginsenoside Rh1 has been reported to possess neuroprotective properties, yet its specific role and underlying mechanisms in AD are not fully ...
Shi‐Lu Li +10 more
wiley +1 more source
Spreading Depolarization bei Patienten mit aneurysmatischer Subarachnoidalblutung
, 2012 Aneurysmal subarachnoid hemorrhage (aSAH) is a life-threatening disease. In Ger-many, approximately 6000 patients suffer from aSAH every year. Mortality and dis-ability rates of patients reaching medical care are 30% and 30%, respectively.
Winkler, Maren Katharina Laura
core +1 more source
, 2023 Supplemental material, sj-xlsx-2-cep-10.1177_03331024221146317 for Genome-wide DNA methylation analysis in an antimigraine-treated preclinical model of cortical spreading depolarization by Marta Vila-Pueyo, Ester Cuenca-León, Ana C. Queirós, Marta Kulis,
José Ignacio Martín-Subero (8824076) +9 more
core +1 more source